Two-Photon Excitation Photodynamic Therapy: Working Toward a New Treatment for Wet Age-Related Macular Degeneration

Probodh, Ira; Cramb, David T.

doi:10.5772/34754

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…The side-effects of PDT in clinical practice, especially the damage on non-tumor cells, can be limited by using selective PDT drugs which are located mainly in the tumor cells or by using focused lasers as light source. PDT damage can be reduced by using two-photon excitation of photosensitizer [58] or by using metronomic PDT (mPDT), method in which the drug and light are delivered at very low dose over an extended period of time [59]. Probably when using natural extracts associated with PDT, an important step is the isolation of the active compounds from the extract and their purification in order to prepare specific drugs for PDT.…”

Section: Discussionmentioning

confidence: 99%

The comparative effects of Resveratrol and Curcumin in combination with photodynamic therapy

Laszló

Popescu

et al. 2022

Medicine and Pharmacy Reports

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Background and aim. Photodynamic therapy, PDT, is a promising option among the local treatments with oncolytic potential. Although the basic principle is simple, its intricate mechanisms allow for a broad range of optimization methods. The purpose of this study was to assess the effects of Resveratrol and Curcumin as adjuvants of PDT on experimental tumors. Methods. Sixty-six Wistar male rats were divided into 11 groups: control, Curcumin (CUR), Resveratrol (RES) alone or followed by irradiation (IR) (CUR+IR and RES+IR, respectively), 5,10,15,20-tetra-sulphonato-phenyl-porphyrin (TSPP), TSPP+IR (PDT), and CUR or RES administered prior to or after PDT (CUR+TSPP+IR, RES+TSPP+IR, TSPP+IR+CUR, TSPP+IR+RES). Results. Both CUR and RES significantly decreased lipid peroxidation, while RES also showed an increase in glutathione (GSH) levels, especially when it was administered before PDT (p<0.01). Both antioxidants decreased cyclooxygenase (COX)2 expression, to a minimum when they administered prior to PDT (p<0.001 and p<0.01) while nitric oxide synthase (NOS)2 expression diminished in the combined regimen, particularly in RES associated with PDT. CUR and RES induced similar changes in terms of cell death, but CUR seemed to be more efficient on tumor necrosis and showed a higher apoptotic index when was administered after PDT (p<0.001). Conclusion. Both RES and CUR in association with PDT decreased oxidative stress, diminished the COX2 and NOS2 expressions and increased cell death by positively influencing the necrotic rate and apoptotic index, particularly when CUR was administered after PDT. The results show that CUR is a promising class to study in PDT optimization and further invites to exploit its promises.

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Section: Discussionmentioning

confidence: 99%

The comparative effects of Resveratrol and Curcumin in combination with photodynamic therapy

Laszló

Popescu

et al. 2022

Medicine and Pharmacy Reports

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show abstract

“…Two-photon excitation, as explained by Probodh and Cramb (2012), is a method using a femtosecond pulsed laser with high peak 78 5. PHOTODYNAMIC THERAPY OF INFECTIOUS DISEASE MEDIATED BY FUNCTIONALIZED FULLERENES power at the focus, whereby the targeted molecule (the PS) is hit by two photons at the same time as half the energy (equivalent to twice the wavelength) of one photon (standard) PDT.…”

Section: Nonlinear Excitationmentioning

confidence: 99%

Photodynamic Therapy of Infectious Disease Mediated by Functionalized Fullerenes

Issa

Hamblin

2015

Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases

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Two-Photon Excitation Photodynamic Therapy: Working Toward a New Treatment for Wet Age-Related Macular Degeneration

Cited by 2 publications

References 33 publications

The comparative effects of Resveratrol and Curcumin in combination with photodynamic therapy

The comparative effects of Resveratrol and Curcumin in combination with photodynamic therapy

Photodynamic Therapy of Infectious Disease Mediated by Functionalized Fullerenes

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