Two-photon Absorption Attenuated THz Generation in GaSe

Ke, 姜可 Jiang; Ji-jiang, 谢冀江 Xie; Guilong, 杨贵龙 Yang; Jingjiang, 谢京江 Xie; Dianjun, 李殿军 Li; Fei, 陈飞 Chen

doi:10.3788/fgxb20153603.0361

发光学报

2015

DOI: 10.3788/fgxb20153603.0361

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Two-photon Absorption Attenuated THz Generation in GaSe

姜可 Jiang Ke

谢冀江 Xie Ji-jiang²,

杨贵龙 Yang Guilong³

et al.

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2018

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“…The pharmacokinetics of breviscapine at a single intravenous dose to rabbits and dogs showed that scutellarin was very fast and rapidly eliminated from the blood. The T 1/2 of scutellarin was (12.0 ± 6.6) min and (6.99 ± 2.74) min in rabbits and dogs respectively (6,7). The ischemic cerebrovascular and cardiovascular diseases dealt with breviscapine are chronic and always require prolonged treatment times.…”

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confidence: 99%

Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats

Liu¹,

Xiong²,

Deng³

et al. 2018

Acta Poloniae Pharmaceutica - Drug Research

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To improve the clinical effect of scutellarin by extending the action time in vivo, scutellarin loaded polymeric micelles were developed by D-alpha tocopherol polyethylene glycol 1000 succinate (Scu/TPGS). Scu/TPGS were prepared using film solvent diffusion methods and characterized on the basis of their particle size, zeta potential, and drug encapsulation efficiency. Dynamic dialysis was used to study the release behavior of the polymeric micelles in vitro. Its pharmacokinetic characteristics and antithrombotic efficacy were studied by intravenous injection in rats. The results showed that Scu/TPGS were spherical, 20.09 ± 2.62 nm in size and a slow release in vitro. The pharmacokinetic parameter T 1/2 of Scu/TPGS was 762.12 ± 46.56 min compared with commercial injection of 59.30 ± 10.67 min (p < 0.05). At the 1 mg/kg dose, the thrombolysis effect of micellar group was stronger than that of the commercial group (p < 0.05). In conclusion, TPGS polymer micelles provided a valid strategy in chemotherapy for cerebrovascular diseases with poor water solubility and poor lipid solubility drugs such as scutellarin.

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mentioning

confidence: 99%

Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats

Liu¹,

Xiong²,

Deng³

et al. 2018

Acta Poloniae Pharmaceutica - Drug Research

View full text Add to dashboard Cite

show abstract

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Two-photon Absorption Attenuated THz Generation in GaSe

Cited by 1 publication

References 0 publications

Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats

Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats

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