Two-phase microfluidic flows

Zhao, Chun‐Xia; Middelberg, Anton P. J.

doi:10.1016/j.ces.2010.08.038

Cited by 342 publications

(223 citation statements)

References 190 publications

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“…6(a), the continuous phase is introduced from the main channel and the dispersed phase flows through the perpendicular channel. The combination of shear stresses generated by the continuous phase and evolution of pressure upstream of the emerging droplet causes the tip of the dispersed phase to elongate into the main channel until the neck of the dispersed phase breaks up into a droplet (Zhao and Middelberg, 2011;Teh et al, 2008). Several modifications of the common T junction geometry have been investigated, including double-pore T junction, which is a hybrid structure between membrane emulsification and standard T junction ), T junction with perpendicular channel extended into the horizontal channel and T junction with injection of the dispersed phase through the main channel .…”

Section: T Junctionmentioning

confidence: 99%

Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices

Vladisavljević

Kobayashi

Nakajima

2012

Microfluid Nanofluid

315

265

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Section: T Junctionmentioning

confidence: 99%

Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices

Vladisavljević

Kobayashi

Nakajima

2012

Microfluid Nanofluid

315

265

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“…These micro-bubbles/droplets offer potential for compartmentalizing biological and chemical reactions within picolitre/nanolitre scale, similar to cellular levels. Further, these micro-bubbles/droplets have wide applications in the field of biomolecule synthesis, biomedical technology, diagnostics, drug delivery, and nanotechnology 1 . Due to prevailing interfacial forces as compared to inertial forces, the physics of a microfluidic system differs significantly from macro-systems.…”

Section: Introductionmentioning

confidence: 99%

“…This holds potential for development of process intensification techniques such as Lab-on-a-Chip (LOC) and Micrototal-analysis-system (μTAS). Additionally, small sample sizes allow rapid, low cost, and highly sensitive analysis of chemical and biological samples in these systems 1 . The microfluidic system reduces transport distances and dilutions caused by Taylor dispersion.…”

Section: Introductionmentioning

confidence: 99%

Numerical Study on Bubble Dynamics and Two-Phase Frictional Pressure Drop of Slug Flow Regime in Adiabatic T-junction Square Microchannel

Kishor

Chandra

Khan

et al. 2017

Chem.Biochem.Eng.Q.

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In this study, bubble dynamics and frictional pressure drop associated with gas liquid two-phase slug flow regime in adiabatic T-junction square microchannel has been investigated using CFD. A comprehensive study on the mechanism of bubble formation via squeezing and shearing regime is performed. The randomness and recirculation profiles observed in the squeezing regime are significantly higher as compared to the shearing regime during formation of the slug. Further, effects of increasing gas velocity on bubble length are obtained at fixed liquid velocities and simulated data displayed good agreement with available correlations in literature. The frictional pressure drop for slug flow regime from simulations are also obtained and evaluated against existing separated flow models. A regression correlation has also been developed by modifying C-parameter using separated flow model, which improves the prediction of two-phase frictional pressure drop data within slug flow region, with mean absolute error of 10 %. The influences of fluid properties such as liquid viscosity and surface tension on the two-phase frictional pressure drop are also investigated and compared with developed correlation. The higher liquid viscosity and lower surface tension value resulted in bubble formation via shearing regime.

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“…Microchannel, water-in-oil dispersion, liquid-liquid flow Introduction Liquid-liquid dispersion within microfluidic devices has become an important issue over the last decade [1]. An emulsion is defined as the temporarily stable dispersion of a liquid into another one that is not miscible [2].…”

Section: Introductionmentioning

confidence: 99%

Comparison between numerical and experimental water-in-oil dispersion in a microchannel

Desjonquéres

Ménard

Tarlet

et al. 2017

Proceedings ILASS–Europe 2017. 28th Conference on Liquid Atomization and Spray Systems

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The dispersion of water inside a flow of oil is investigated in a microfluidic device, producing a water-in-oil emulsion. The liquid-liquid flow mainly differs from those presented in existing literature through its high capillary number (between 3 and 14), and in the head-on collision between water and oil streams. By comparing with experimental data, numerical simulations can provide more information about the topology of the flow. A coupled Volume of Fluid and Level Set method (CLSVOF) is used to treat the interface between both phases and incompressible Navier-Stokes equations are solved. Three set of parameters, close to those in the experimental setup, are investigated to compare experimental and numerical results. The comparison between experiments and simulation provides a precise knowledge of the liquid-liquid dispersion process and the overall flow pattern within the microfluidic device. KeywordsMicrochannel, water-in-oil dispersion, liquid-liquid flow Introduction Liquid-liquid dispersion within microfluidic devices has become an important issue over the last decade [1]. An emulsion is defined as the temporarily stable dispersion of a liquid into another one that is not miscible [2]. When the scale of the liquid-liquid flow is smaller than its capillary length [3], interfacial tension dominates over shear stress and gravity [4], making the dispersion highly reproducible in slow conditions [5]. These slow conditions ensure a highly monodisperse emulsion [6], that is usually appropriate for targeted applications like microreaction synthesis [7]. However, other application like high flow-rate biofuel production [8] benefit from the considerably increased surface-to-volume ratio [9,10] of microfluidic liquid-liquid dispersion. In order to better understand the physics of microfluidic in high flow-rate liquid-liquid dispersion, experimental results of the obtained mean diameter and liquid-liquid flow photographies [8] are compared to numerical results. At the present stage, a quantitative validation of the model is not obtained, but we present a qualitative comparison of the liquid-liquid flow pattern. In a first part, experimental material and methods are presented, then numerical methods used to investigate such flows are briefly detailed. Finally, first comparisons are discussed.

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Two-phase microfluidic flows

Cited by 342 publications

References 190 publications

Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices

Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices

Numerical Study on Bubble Dynamics and Two-Phase Frictional Pressure Drop of Slug Flow Regime in Adiabatic T-junction Square Microchannel

Comparison between numerical and experimental water-in-oil dispersion in a microchannel

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