Two Periods in the Response of the Skin Cold Receptors to Intravenous Infusion of Noradrenaline

Козырева, Т. В.

doi:10.1111/j.1749-6632.1997.tb51689.x

Cited by 9 publications

(4 citation statements)

References 5 publications

(6 reference statements)

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“…Besides that, NE effects on the skin and brain thermal afferents and can change their sensitivity to temperature -this is feedback to afferents. [4][5][6][7][8] The character of ATP influence on impulse activity of thermal afferents requires the following researches.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Increase in NE concentration causes the changes in the function of effector organs and modulate the activity of afferent nervous fibers including thermosensitive. Support came from researches showing that exogenous NE can modify not only the function of effector organs (muscles, brown adipose tissue, blood vessels e. c., this is well known), but also impulse activity of the skin thermoreceptors [4][5][6][7][8] and thermosensitive neurons in the hypothalamus. 9 Modulation of thermoreceptor activity by exogenous NE is associated with shifts of a set of regulatory parameters of the thermal homeostasis system and changes in the thermal thresholds and the magnitude of cold defense responses.…”

Section: Introductionmentioning

confidence: 99%

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Effect of the sympathetic nervous system co-transmitters ATP and norepinephrine on thermoregulatory response to cooling

2015

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The existence of co-transmitters of the sympathetic nervous system norepinephrine (NE) and ATP implies variations in the neuromodulator mechanisms of physiological processes. The role of ATP, as a transmitter of the peripheral part of sympathetic nervous system in the formation of thermoregulatory response is not clear. Whether ATP modulates any parameters of thermoregulatory response to cold; if yes, whether co-transmitters of sympathetic nervous system ATP and NE differently modulate thermoregulatory response and on which parameters of cold-defense response the influence of ATP is more pronounced. Experiments were carried out on rats. ATP (10−6), NE (10−3), and their mixture introduced iontophoretically into skin. Their effects on thermoregulatory parameters (temperature parameters, total oxygen consumption, carbon dioxide release, muscle activity, respiratory coefficient) were studied in thermoneutral conditions (without cold load) and under the cooling. In thermoneutral conditions both ATP and NE enhance total metabolism through increase in metabolic rate of lipids, NE effect being more expressed. It was shown that ATP and NE influence predominantly on the different components of the metabolic response to cold. ATP affects to the greatest extent on cold muscular thermogenesis by increasing shivering almost twofold and lowering its initiation temperature thresholds, whereas NE mainly promotes increase in non-shivering thermogenesis. When introducing the mixture of these biological substances the effect of NE is more expressed and the ATP effect is weakened. The obtained results allow to suggest that in vivo the NE effects can be more expressed when the sympathetic nervous system is stimulated by cold. Thus, NE and ATP being co-transmitters and predominantly acting on the different processes of cold thermogenesis (ATP on shivering and NE on non-shivering) may organize the certain sequence of cold defense responses.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of the sympathetic nervous system co-transmitters ATP and norepinephrine on thermoregulatory response to cooling

2015

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“…As for the peripheral skin thermoreceptors, our studies (Kozyreva, 1997) using intravenous noradrenaline infusion (10 ng/g min, the rate of infusion 0.03 ml/min) demonstrated the following. An increase in the concentration of noradrenaline affects both the static and dynamic activities of the skin cold receptors (Fig.…”

Section: Peripheral Skin Thermoreceptorsmentioning

confidence: 90%

“…An examples of change in the static and dynamic activity of low-frequency (A) and high-frequency (B) cold skin receptors in the area of n. sapheni innervation, total oxygen consumption and rectal temperature under the effect of intravenous noradrenaline infusion (10 ng/g min, 0.03 ml/s). Totally 28 cold receptors were studied in this series (figures from Kozyreva, 1997). remained unaltered.…”

Section: Temperature Sensationmentioning

confidence: 99%

Neurophysiological aspects of the long-term adaptation to cold in mammals: The role of central and peripheral thermoreceptors

Козырева¹

2006

Journal of Thermal Biology

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Development of Research on the Thermoregulatory System in Russia

Козырева

2022

Thermal Physiology

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Two Periods in the Response of the Skin Cold Receptors to Intravenous Infusion of Noradrenaline

Cited by 9 publications

References 5 publications

Effect of the sympathetic nervous system co-transmitters ATP and norepinephrine on thermoregulatory response to cooling

Effect of the sympathetic nervous system co-transmitters ATP and norepinephrine on thermoregulatory response to cooling

Neurophysiological aspects of the long-term adaptation to cold in mammals: The role of central and peripheral thermoreceptors

Development of Research on the Thermoregulatory System in Russia

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