Two Patients with Highly Aggressive Macrofollicular Variant of Papillary Thyroid Carcinoma

Cardenas, Monica G.; Kini, Sudha R.; Wisgerhof, Max

doi:10.1089/thy.2008.0178

Cited by 24 publications

(15 citation statements)

References 15 publications

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“…Also, in the study by Cardenas et al 2 cases with aggressive behaviour (extrathyroid extension, lymph nodes, and bone and lung metastases) were reported [12]. In this study, distant metastasis and death were not detected in a mean follow-up period of 7.2 years, and locoregional recurrence rate was observed to be high (60%).…”

Section: Discussionsupporting

confidence: 49%

Papillary Thyroid Cancer, Macrofollicular Variant: The Follow-Up and Analysis of Prognosis of 5 Patients

Erol

Makay

Ertan

et al. 2014

Journal of Thyroid Research

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Objective. The main aim of this study was to comparatively analyze the recurrence and prognosis of this rare variant with the literature by analyzing the follow-up data of 5 patients diagnosed with papillary cancer macrofollicular variant. Methods. The demographic data, radiological and pathological data, and prognostic data of 5 patients who underwent surgery for thyroid cancer and were diagnosed with papillary cancer macrofollicular variant pathologically were retrospectively analyzed. Results. The mean age of patients whose mean follow-up period was determined as 7.2 years was 41, and the male/female ratio was 4/1. All patients underwent total thyroidectomy. The pathology report of 2 patients (40%) revealed macrofollicular variant of papillary microcancer, and 3 patients papillary cancer macrofollicular variant. Central dissection was performed in one patient (20%) due to macroscopic pathologic lymph node and 4 metastatic lymph nodes were reported. Also, locoregional recurrence was present in 3 out of 5 patients (60%). Conclusions. Although an impression of earlier and increased risk of recurrence in papillary carcinoma with macrofollicular variant has been documented, more studies with extensive follow-up times and large populations are required.

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Section: Discussionsupporting

confidence: 49%

Papillary Thyroid Cancer, Macrofollicular Variant: The Follow-Up and Analysis of Prognosis of 5 Patients

Erol

Makay

Ertan

et al. 2014

Journal of Thyroid Research

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“…To our knowledge, there is no study of HBME-1 staining in the Warthin-like variant of PTC, while there are only two reports concerning its expression in the macrofollicular variant of PTC with findings similar to ours [14,31]. The macrofollicular variant of PTC is an uncommon tumour that can be confused with nodular goiter or follicular adenoma [32]. This variant, despite being described as having a good prognosis with a low incidence of metastases, can sometimes present as a highly aggressive tumour, making its detection and proper characterization of importance.…”

Section: Discussionsupporting

confidence: 48%

Strong Expression of HBME-1 Associates with High-Risk Clinicopathological Factors of Papillary Thyroid Carcinoma

Denčić

Savin

Šelemetjev

et al. 2015

Pathol. Oncol. Res.

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Thyroid cancer comprises a heterogeneous group of lesions with great diversity of biological behaviour. Markers which could help clinicians to identify high-risk patients for tailored optimization of clinical management are of crucial importance. HBME-1 protein level was analysed immunohistochemically using routinely prepared archival tissue sections of a broad range of papillary thyroid carcinoma (PTC) variants and in corresponding lymph node metastases (LNM). The results were evaluated in comparison with clinicopathological features of PTC. Positive immunoreaction was noticed in most classical (83/92; 90.2 %), follicular (60/71; 84.5 %) and trabecular (4/5; 80.0 %) variants of PTC. All cases of macrofollicular, Warthin-like and diffuse sclerosing PTC variants were HBME-1 positive (4/4, 3/3, 2/2; 100 % respectively). Tall cell and solid PTC variants showed diversity of staining (2/3; 66.67 % and 13/23; 56.52 % respectively), while PTCs with mixed histological pattern containing insular areas were mainly weakly positive (2/5; 40.0 %). A single case of clear cell PTC variant showed no reaction. Moreover, all matched metastatic PTC into lymph nodes (LNM) were HBME-1 positive (17/17; 100 %) and expressed HBME-1 in a similar pattern to the matched primary tumour. We also found a statistically significant association between high HBME-1 expression and the presence of lymph node metastasis, advanced pT status and pTNM stage (P < 0.05), but only a tendency for association with extrathyroidal invasion of the tumour (P = 0.058). Therefore, we recommend using immunoexpression of HBME-1 as useful mean to increase the likelihood of detecting most PTC variants and to predict some unfavourable clinical parameters in these patients.

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“…In a series reported by Albores-Saavedra et al4 in 1996, two patients with a large-sized tumor, insular component and blood vessel invasion developed lung metastasis. In 2009, Cardenas et al10 also reported two similar cases with aggressive behavior, represented by extra-thyroid extension, lymph node involvement, and bone and lung metastases. The aggressive behavior of these cases may be related to capsular and/or vascular invasion.…”

Section: Discussionmentioning

confidence: 96%

Three cases of macrofollicular variant of papillary thyroid carcinoma

Raddaoui

Maha

Kfoury

et al. 2011

Annals of Saudi Medicine

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The macrofollicular variant of papillary thyroid carcinoma (MFPTC) is a well-established entity with characteristic large follicles containing pale colloid and lined by cells with nuclear features of papillary thyroid carcinoma (PTC). In this study, we present three cases of MFPTC, along with a brief review of the literature. For all three of our cases, the histology of the resected specimen showed predominantly macrofollicular structures lined by cells with nuclear characteristics of PTC. Immunohistochemically, the three cases show positivity for galactin-3, cytokeratin-19, and HBME-1. These cases will help us in understanding the distinction from other benign and malignant follicular lesions of the thyroid, which is of utmost importance. The key to diagnosis is a high-power examination of any macrofollicular lesion of the thyroid.

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Two Patients with Highly Aggressive Macrofollicular Variant of Papillary Thyroid Carcinoma

Cited by 24 publications

References 15 publications

Papillary Thyroid Cancer, Macrofollicular Variant: The Follow-Up and Analysis of Prognosis of 5 Patients

Papillary Thyroid Cancer, Macrofollicular Variant: The Follow-Up and Analysis of Prognosis of 5 Patients

Strong Expression of HBME-1 Associates with High-Risk Clinicopathological Factors of Papillary Thyroid Carcinoma

Three cases of macrofollicular variant of papillary thyroid carcinoma

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