Two parameters reflect lipid-driven inflammatory state in acute coronary syndrome: atherogenic index of plasma, neutrophil–lymphocyte ratio

Zhan, Youqin; Xu, Tan; Tan, Xuerui

doi:10.1186/s12872-016-0274-7

Cited by 43 publications

(34 citation statements)

References 29 publications

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“…These data indicated that IL-8 level is affected by intensity of exercise. The present study detected significant increase in atherogenic index in both obese non-ovx and obese ovx subgroup versus lean subgroup, these results also comes in agreement with other several studies, As Pourfarzam, et al [63] ; Zhan et al [64] ; Gaojun Cai et al [65] ; Shen et al [66] demonstrated that atherogenic index associated with metabolic syndrome and it was higher in coronary heart diseases. Furthermore it was positively correlated with TC, TG and negatively correlated with HDL-C.…”

Section: Discussionsupporting

confidence: 93%

The Effect of Moderate Exercise on Monocyte Chemo-Attractant Protein-1 in Atherogenic Ovariectomized Rats

hamed¹,

Ahmed²,

Bedair³

et al. 2018

Zagazig University Medical Journal

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Background: Cardiovascular disease (CVD) is one of the leading causes of death worldwide and is more prevalent in post-menopausal women. Monocyte chemo-attractant protein-1(MCP-1) is a chemokine that attracts monocytes/macrophages to sites of inflammation and play a role in development of atherosclerosis. Objective: This study aimed to explore the effects of ovariectomy (Ovx) as a model of menopause on the serum level of MCP-1 in high fat diet induced atherogenesis and clarify the modulatory effects of moderate exercises on the serum level of MCP-1 in this model. Animals and methods: 96 female albino rats divided equally into 4 groups, each is subdivided equally into 2subgroups subgroup (Ia): non ovx ,sedentary, fed standard diet for 10 weeks, subgroup (Ib): non ovx ,sedentary, fed high fat diet for 10 weeks. Subgroup (IIa) ovx sedentary, fed standard diet for 10 weeks subgroup (IIb): ovx, sedentary fed high fat diet for 10 weeks. Subgroup (IIIa): non ovx ,exercised and fed standard diet for 10 weeks. subgroup (IIIb) non ovx ,exercised and fed high fat diet for 10 weeks. Subgroup (IVa): ovx ,exercised and fed standard diet for 10 weeks. subgroup (IVb) ovx ,exercised and fed high fat diet for 10 weeks. Results: in ovx obese sedentary rats, there was a significant (p <0.001) increase in MCP-1,Lipid profile, Atherogenic indices, Platelets activation percentage, Total leucocytic counts, Differential monocyte counts, and Interleukin 8 and aortic thickness versus lean subgroup. Swimming exercise showed significant (p <0.001) reductions in the above parameters, associated with significant increase in the serum HDL level in ovx obese exercised subgroup versus ovx obese sedentary subgroup. Conclusions: MCP-1 level increased in obesity and menopause leading to development of atherosclerosis and these changes could be reversed by adaptive moderate exercises.

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Section: Discussionsupporting

confidence: 93%

The Effect of Moderate Exercise on Monocyte Chemo-Attractant Protein-1 in Atherogenic Ovariectomized Rats

hamed¹,

Ahmed²,

Bedair³

et al. 2018

Zagazig University Medical Journal

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“…When taking into account the fact that there is a significant relationship between these two risk scoring systems and N/L ratios and N/L ratio is higher in patients with higher troponin levels, this supports other literature information and considerations of important authors about N/L ratio can be used as a practical risk marker in ACS. In a study of Zhan et al, N/L ratio was found highest in the STEMI group among the ACS subgroups [28].…”

Section: Discussionmentioning

confidence: 89%

Evaluation of white blood cell and neutrophil/lymphocyte ratio in acute coronary syndrome patients admitted to emergency department

Goktas¹,

Akyol²,

Karakaya³

et al. 2018

biomedicalresearch

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Objective: Inflammatory reaction, which causes tissue damage in Acute Coronary Syndrome (ACS), leads to deterioration. White Blood Cell (WBC), Neutrophil (N), Lymphocyte (L) and Neutrophil/ Lymphocyte (N/L) ratios were used to refer to the inflammation. High neutrophil levels show us acute inflammatory situation and low lymphocyte levels show us physiological stress. That is why N/L ratio is a valuable parameter which enables us to guess patient prognosis in Emergency Department (ED). In this study, white cell and NLR relations with ACS in patients with chest pain is evaluated. Material and method: Patients referring to ED with chest pain within 3 months were investigated retrospectively. 100 patients were included in the study. Patients' WBC count, NLR and WBC values, gender, Troponin-I and CK-MB positivity, history of Coronary Heart Disease (CHD) and additional diseases were examined according to the final diagnoses. All the patients were divided into three groups according to ACS: Unstable Angina Pectoris (USAP), Non-ST Elevated Myocardial Infarction (NSTEMI), and ST-Elevated Myocardial Infarction (STEMI). Mortality and morbidity levels in hospital and after discharge were also examined in the study. Findings: WBC values in patients with positive Troponin-I were found statistically higher than patients with negative Troponin-I (p<0.05). In STEMI group, WBC values were statistically higher than USAP group (p<0.0083). When patients' N/L ratio average distribution was examined; Troponin-I and CK-MB positive patients' NLR was found to be statistically higher than Troponin-I and CK-MB negative ones (p<0.05). Conclusion: N/L ratio, which is a marker of inflammatory process in the myocardial vascular bed, may be considered as a risk marker. For this reason, N/L ratio at admission can be used as an auxiliary parameter for predicting the diagnosis of ACS.

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“…There are studies in which the TG and HDL and the ratio of TG and HDL can be used to calculate the PAI. Zhan et al [19] showed that PAI levels were higher in acute coronary syndrome patients compared to controls. Niroumand et al [7] determined that PAI can be used as an indicator of the cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus

et al. 2017

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Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients. Materials and Methods:We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria. Furthermore, we selected age-and body mass index (BMI)-matched 56 female healthy individuals. PAI was measured as a logarithmic value of triglyceride to high-density cholesterol ratio. We used carotid intima media thickness (cIMT) as an inflammatory marker because of its widespread use. The lipid and other biochemical parameters of patient and control groups were examined.Results: The PAI and cIMT values of SLE patients were 0.04±0.23 and 0.78±0.18 mm, respectively. Besides, for the control group, the PAI value was −0.09±0.20 and cIMT value was 0.50±0.15 mm (p=0.002, p<0.001; respectively). There was a strong correlation between cIMT and PAI (r=0.273, p=0.003). According to the multiple logistic regression analysis, we found that PAI value is an independent factor for cIMT in SLE patients (odds ratio: 2.6, 95 % confidence interval; 1.506-4.374; p=0.029). Conclusions:We determined that PAI can be used as an independent indicator for subclinical atherosclerosis in SLE patients.Keywords: Plasma atherogenic index, carotid intima-media thickness, systemic lupus erythematosus, atherosclerosis ÖZ Amaç: Sistemik lupus eritematozus (SLE), kronik inflamasyon ile karakterize bir hastalıktır. Plazma aterojenik indeks (PAI), kardiyovasküler hastalık ve kardiyak risk için değerli bir belirteçtir. Bu çalışmanın amacı PAI'in SLE hastalarında aterosklerozu ve kardiyak riski değerlendirmekteki rolü ve klinik kullanılabilirliliğini araştırmaktır.Gereç ve Yöntem: Amerikan Romatoloji Koleji (1997) tanı kriterlerine göre değerlendirilen 56 kadın SLE hastası dahil edildi. Ayrıca yaş ve vucüt kitle indeksi uyumlu 56 kadın sağlıklı kişi seçildi. PAI, trigliserit'in yüksek yoğunluklu kolesterole oranı logartimik ölçümüdür. Karotis intima medya kalınlığı (KIMK) inflamatuvar belirteç olarak yaygın olarak kullanıldığından, bu işareti bu çalışmada kullandık. Hasta ve kontrol gruplarının lipid ve diğer biyokimyasal parametreleri incelendi.Bulgular: Hasta grubunda PAI 0,04±0,23, KIMK 0,78±0,18 mm, kontrol grubunda PAI -0,09±0,20, KIMK 0,50±0,15 mm olduğu tespit edildi. Hasta grubunda PAI ve KIMK'ın kontrol grubuna kıyasla yüksek olduğu görüldü (sırasıyla p=0,002, p<0,001). SLE hastaları içerisine KIMK ile PAI arasında pozitif korelasyon olduğu görüldü (r=0,273, p=0,003). Multipl logistik regresyon analize göre PAI, KIMK için bağımsız risk faktörü olarak değerlendirildi (Olasılık oranı: 2,6, Güven aralığı %95 1,506-4,374, p=0,029).Sonuç: Bu çalışma bize PAI'nın SLE hastalarında subklinik aterosklerozun değerlendirilmesinde kullanılabilecek bağımsız bir belirteç olabileceğini d...

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Two parameters reflect lipid-driven inflammatory state in acute coronary syndrome: atherogenic index of plasma, neutrophil–lymphocyte ratio

Cited by 43 publications

References 29 publications

The Effect of Moderate Exercise on Monocyte Chemo-Attractant Protein-1 in Atherogenic Ovariectomized Rats

The Effect of Moderate Exercise on Monocyte Chemo-Attractant Protein-1 in Atherogenic Ovariectomized Rats

Evaluation of white blood cell and neutrophil/lymphocyte ratio in acute coronary syndrome patients admitted to emergency department

Plasma Atherogenic Index is an Independent Indicator of Subclinical Atherosclerosis in Systemic Lupus Erythematosus

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