Two oxovanadium complexes incorporating thiosemicarbazones: synthesis, characterization, and DNA-binding studies

Lu, Jiazheng; Du, Yifan; Guo, Haiwei; Jiang, Jing; Zeng, Xiandong; Zang, Lei

doi:10.1080/00958972.2011.565754

Cited by 34 publications

(28 citation statements)

References 40 publications

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“…) at 260 nm [20]. The oxovanadium complexes were dissolved in DMSO and diluted with buffer solution to the required concentrations prior to use.…”

Section: Methodsmentioning

confidence: 99%

“…In order to further elucidate the binding strength of the complex, the intrinsic binding constant K b with CT-DNA was obtained by monitoring the change in the absorbance of the ligand transfer band with increasing amounts of DNA. K b was then calculated using the following equation [13,20,28] )…”

Section: Dna-binding and Photocleavagementioning

confidence: 99%

“…Previously, we have reported some oxovanadium (IV) complexes incorporating 1,10-phenanthroline (phen) or bipyridyl (bpy) present high DNA intercalator, photocleavage properties and cytotoxicity in vitro [13,[19][20]. Although the molecular basis for the DNAbinding properties of oxovanadium (IV) compound is not completely understood at the present time, it occurs to us that oxovanadium complexes bearing phen moiety possess higher DNA-binding activities and more potent inhibitory effect against cancer cell lines than that of bearing bpy moiety.…”

Section: Introductionmentioning

confidence: 99%

“…Oxovanadium complexes incorporated with thiosemicarbazones have demonstrated both in vitro antibacterial and antiproliferative properties [18][19] as well as intense interaction with DNA [20]. On the other hand, 1,10-phenanthroline and its derivatives were usually served as a very efficient class of ligands, which lead to efficient catalysis in cross coupling reaction of aliphatic alcohols and aryl halides [21], antimicrobial activities [22], efficient DNA-binding and DNA cleavage [23] thus inducing significant cytotoxicity in the cultured cells [24].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Synthesis, DNA-binding, Photocleavage and in vitro Cytotoxicity of Novel Imidazole[4,5-f][1,10]phenanthroline-based Oxovanadium Complexes

Ying¹

2014

Med chem

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“…) at 260 nm [20]. The oxovanadium complexes were dissolved in DMSO and diluted with buffer solution to the required concentrations prior to use.…”

Section: Methodsmentioning

confidence: 99%

Section: Dna-binding and Photocleavagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, DNA-binding, Photocleavage and in vitro Cytotoxicity of Novel Imidazole[4,5-f][1,10]phenanthroline-based Oxovanadium Complexes

Ying¹

2014

Med chem

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“…) at 260 nm [41,42]. The CT-DNA in buffer gave a ratio of UV absorbance at 260 and 280 nm of 1.8-1.9, indicated the DNA free of protein [43][44][45] [complex] produced a slope of 1/(εb -εf), and a Y intercept equal to 1/Kb(εb -εf); Kb is the ratio of slope to the Y intercept [46].…”

Section: Dna Bindingmentioning

confidence: 99%

Synthesis, Characterization, Anticancer, DNA Binding and Antioxidant Studies of Benzylamine Supported Pd (II) Complex

Sharma¹,

Ameta²,

Singh³

2018

J Can Sci Res

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Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

Shebl

Khalil

2014

Monatsh Chem

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Two pentadentate carbohydrazone ligands, H 2 L 1 and H 2 L 2 , were prepared by the reaction of the bifunctional compound carbohydrazide with 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde, respectively. Reactions of the ligands with oxovanadium(IV), cerium(III), thorium(IV), and dioxouranium(VI) ions yielded binary complexes. Reactions of the ligands with the dioxouranium(VI) ion in the presence of secondary ligands (8-hydroxyquinoline, glycine, salicylaldehyde, or benzoylacetone) yielded ternary complexes. The ligands and metal complexes were characterized by different techniques such as elemental and thermal analyses, IR, 1 H and 13 C NMR, electronic, ESR, mass spectra, and powder XRD as well as magnetic susceptibility and conductivity measurements. The coordinating sites are phenolic oxygen, azomethine nitrogen, and carbonyl oxygen. In complexes, the ligands act as dibasic pentadentate except ternary dioxouranium(VI) complexes, obtained using glycine or benzoylacetone, in which the ligands act as monobasic pentadentate. The XRD patterns for the H 2 L 1 ligand, its binary dioxouranium(VI) complex, and its 8-hydroxyquinoline ternary complex indicate crystalline nature and the grain size was estimated. The H 2 L 1 ligand and its binary complex have triclinic systems while the ternary complex has a monoclinic system with different unit-cell parameters. The ligands and some of their metal complexes showed antimicrobial activity toward some Gram-positive and Gram-negative bacteria, yeast (Candida albicans), and fungus (Aspergillus fumigatus), and MIC values were determined. The DNA binding properties of the oxovanadium(IV) complexes of H 2 L 1 and H 2 L 2 ligands were investigated by electronic absorption spectroscopy and viscosity measurements. The results indicated that these complexes bind to DNA via an intercalation binding mode with an intrinsic binding constant K b of 2.55 9 10 4 and 3 9 10 4 M -1 , respectively.

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Two oxovanadium complexes incorporating thiosemicarbazones: synthesis, characterization, and DNA-binding studies

Cited by 34 publications

References 40 publications

Synthesis, DNA-binding, Photocleavage and in vitro Cytotoxicity of Novel Imidazole[4,5-f][1,10]phenanthroline-based Oxovanadium Complexes

Synthesis, DNA-binding, Photocleavage and in vitro Cytotoxicity of Novel Imidazole[4,5-f][1,10]phenanthroline-based Oxovanadium Complexes

Synthesis, Characterization, Anticancer, DNA Binding and Antioxidant Studies of Benzylamine Supported Pd (II) Complex

Synthesis, spectral, X-ray diffraction, antimicrobial studies, and DNA binding properties of binary and ternary complexes of pentadentate N2O3 carbohydrazone ligands

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