2020
DOI: 10.1101/2020.06.18.158931
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Two opposite voltage-dependent currents control the unusual early development pattern of embryonic Renshaw cell electrical activity

Abstract: A remarkable feature of the developing central nervous system is the generation of spontaneous network activity (SNA) at the onset of synaptogenesis. In the spinal cord (SC) of the mouse embryo, SNA occurs around the 12 th embryonic day (E12.5) and involves a recurrent functional loop between motoneurons (MNs) and GABAergic interneurons. We previously showed that Renshaw cells (V1 R ), which constitute a functionally homogeneous population in the adult, are the first neurons enriched with GABA in the mouse emb… Show more

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