Two ophthalmic presentations of chronic myeloid leukaemia

Abstract

Chronic myeloid leukaemia (CML) is a myeloproliferative neoplasm that accounts for 15% of newly diagnosed cases of leukaemia in adults [1]. In the developed world, 50% of patients are asymptomatic at diagnosis with the disease picked up on routine examination and blood testing. At presentation, 90%-95% of patients have chronic phase CML during which signs and symptoms typically result from anaemia and splenomegaly [2]. Ophthalmic presentations of CML are uncommon, F I G U R E 1 (A and B) Right and left wide-field fundus images showing bilateral Roth spots and peripheral perivascular sheathing. (C and D) Improvement at 4 weeks following treatment This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Ophthalmic presentation of chronic myeloid leukemia in two adolescents

“…Ophthalmic presentation of CML is a rare event. A recent literature review found 40 published cases in the preceding 49 years 1 and at least seven further cases have subsequently been reported 2–6 . The median WBC count amongst patients with ophthalmologic involvement was 249 × 10 9 /L (range 50–688 × 10 9 /L).…”

“…A recent literature review found 40 published cases in the preceding 49 years 1 and at least seven further cases have subsequently been reported. [2][3][4][5][6] The median WBC count amongst patients with ophthalmologic involvement was 249 Â 10 9 /L (range 50-688 Â 10 9 /L). There was a male preponderance with an age range of 9-68 years (median 35 years).…”