Two novel ternary albendazole–cyclodextrin–polymer systems: Dissolution, bioavailability and efficacy against Taenia crassiceps cysts

Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice

“…In fact, the relative bioavailability of the sulphoxide metabolite increased 96% after the treatment with ABZ-LNCs compared to ABZ-SUSP. These results agree with previous studies, where the use of different formulations was assessed to increase ABZ bioavailability (Shuhua et al, 2002;Ceballos et al, 2008;Palomares-Alonso et al, 2010;Castro et al, 2012). As similar C max values for ABZ-SO were detected after the administration of both ABZ formulations, the higher AUC value obtained after ABZ-LNCs could be explained by the longer ABZ-SO residence time in the bloodstream observed in these experimental groups.…”

“…Regarding this, different efforts related to the formulation process have been made to enhance ABZ water solubility and dissolution rate such as soybean oil emulsion (Shuhua et al, 2002), liposomes (Dvorožňáková et al, 2004), cyclodextrins (Palomares-Alonso et al, 2010), and solid dispersions (Castro et al, 2012). In addition, several clinical studies have demonstrated that enhanced systemic availability of the parent drug/active metabolite obtained by increased drug absorption correlates with an improved antiparasitic effect (Shuhua et al, 2002;Dvorožňáková et al, 2004;Ceballos et al, 2008;Palomares-Alonso et al, 2010;Pensel et al, 2014).…”

“…In addition, several clinical studies have demonstrated that enhanced systemic availability of the parent drug/active metabolite obtained by increased drug absorption correlates with an improved antiparasitic effect (Shuhua et al, 2002;Dvorožňáková et al, 2004;Ceballos et al, 2008;Palomares-Alonso et al, 2010;Pensel et al, 2014).…”

Murine cysticercosis model: Influence of the infection time and the time of treatment on the cysticidal efficacy of albendazole and praziquantel

“…To date, the evaluation of the in vivo efficacy of new cysticidal drug treatments has been performed using T. crassiceps WFU strain (Palomares-Alonso et al, 2010;Zurabian et al, 2013); however, this strain shows a gradual loss of its infective ability after serial consecutive peritoneal passage in mice (Zurabian et al, 2008), which has not been reported for the ORF strain. Therefore, we selected the experimental infection model of T. crassiceps ORF in mice as a suitable model for the screening of new cysticidal drugs.…”

Development and Validation of the Rp-HPLC Method for Determination of Benzimidazole Carbamates in the Presence of Cyclodextrins

“…Different strategies have been employed to increase the solubility of BZD, including the preparation of solid dispersions, the use of surfactants, liposomes and the development of inclusion complexes with cyclodextrins (CDs) 3,[6][7][8][9][10] .…”