Two Novel [68Ga]Ga-Labeled Radiotracers Based on Metabolically Stable [Sar11]RM26 Antagonistic Peptide for Diagnostic Positron Emission Tomography Imaging of GRPR-Positive Prostate Cancer
Panagiotis Kanellopoulos,
Ekaterina Bezverkhniaia,
Ayman Abouzayed
et al.
Abstract:Gastrin releasing peptide receptor (GRPR) is overexpressed in prostate cancer (PC-3) and can be used for diagnostic purposes. We herein present the design and preclinical evaluation of two novel NOTA/NODAGA-containing peptides suitable for labeling with the positron emission tomography (PET) radionuclide Ga-68. These analogs are based on the previously reported GRPR-antagonist DOTAGA-PEG2-[Sar 11 ]RM26, developed for targeted radiotheraostic applications. Both NOTA-PEG2-[Sar 11 ]RM26 and NODAGA-PEG2-[Sar 11 ]R… Show more
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