Two Novel Potential Anticonvulsant Salts of 5-Amino-2-Sulfonamide-1,3,4-Thiadiazole

Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action

“…In a previous work, we have reported the crystal structures and spectroscopic characterization of Hats.MeSO 3 H and Hats.HCl 22,23 . Crystal and experimental data for Hats.tosylate are listed in Table 1.…”

“…Despite the development of a rapid tolerance consisting in diminished therapeutic efficacy after the initial response of the patients, acetazolamide is still used in combination therapy with other antiepileptic drugs or inrefractory epilepsies 1 . We have obtained and determined the crystal structures of sulfonamides incorporating the 1,3,4-thiadiazole ring [17][18][19][20][21][22][23] . The results obtained by our group with these sulfonamides indicated a notable increase in the CA inhibitory properties of metal complexes of sulfonamides such as acetazolamide or its deacetylated precursor, 5-amino-1,3,4-thiadiazole-2-sulfonamide (Hats) 23 .…”

“…The results obtained by our group with these sulfonamides indicated a notable increase in the CA inhibitory properties of metal complexes of sulfonamides such as acetazolamide or its deacetylated precursor, 5-amino-1,3,4-thiadiazole-2-sulfonamide (Hats) 23 . Furthermore, continuing our studies on unsubstituted heterocyclic sulfonamides and their metal complexes [17][18][19][20][21][22][23] , we started to study the role of new salts of Hats with regard to their biological activity. In this work, we report new salts of Hats with p-toluenesulfonic acid, methylsulfonic acid, and the hydrochloride monohydrate salts.…”