Two novel oligosaccharides from Solanum nigrum

Chen, Rong; Feng, Lei; Li, Hai-Dao; Zhang, Hua; Yang, Fei

doi:10.1016/j.carres.2009.06.013

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…Although it may be produced from the complete plant, crude extract is frequently produced with dried fruits. (HepG2) (Ji et al, 2008;Lee et al, 2004) (HT29 and HCT-116) (Ji et al, 2008), Breast (Lee et al, 2004) (MCF-7), cervical cancer (Li et al, 2009) (U1424, 25 and HeLa27). The antimutagenic activity of these fractions was examined by examining the toxicity of the isolate on cells.…”

Section: Pharmacology Of S Nigrum Linnmentioning

confidence: 99%

Medicinal Importance of Solanum nigrum Linn; A Review

Zeeshan,

Amjad,

Amjad

et al. 2023

J. Plant Environ.

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Solanum nigrum (Black nightshade) is an indigenous medicinal plant that has been utilized in traditional medical systems for ages. S. nigrum includes bioactive substances such as alkaloids, flavonoids, steroids, and saponins, according to phytochemical research. Extracts and isolated chemicals indicate antioxidant, anti-inflammatory, antibacterial, antifungal, anti-diabetic, anti-cancer, immune-stimulating, therapeutic, and heart-protective effects. S. nigrum extracts, in particular, limit cancer cell growth, minimize chemically induced organ damage, alter immunological function, and provide protection against oxidative stress, according to animal and cell culture studies. S. nigrum has traditionally been used for the prevention of symptoms such as discomfort, inflammation, infections, and problems with the gastrointestinal tract. Overall, this comprehensive study reveals the varied therapeutic qualities of S. nigrum that demand further exploration.

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Section: Pharmacology Of S Nigrum Linnmentioning

confidence: 99%

Medicinal Importance of Solanum nigrum Linn; A Review

Zeeshan,

Amjad,

Amjad

et al. 2023

J. Plant Environ.

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“…The fruits are rich sources of saponins and steroidal glycol-alkaloids (solanine, solamargine, solasonine, a and bsolanigrine) and the aglycone, solasodine, steroidal genin, trigogenin (Karmakar et al, 1970;Ghani, 2003), and two new disaccharides, as well as protein, minerals such as magnesium, phosphorus, and vitamins C, B, and folic acid. These disaccharides are ethyl beta-d-thevetopyranosyl -(1-4) -beta -D-oleandropyranoside and ethyl beta -d-thevetopyranosyl-(1-4) -alpha -D-oleandro-pyranoside isolated by chemical and spectroscopic methods(R. Chen et al, 2009). Seeds consist of solanine, protein, greenish-yellow oil consisting of linoleic, oleic, palmitic, stearic acids, and sitosterol (Karmakar et al, 1970).…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

A Sneak peek (1970-2021) Into Phytochemistry and Ethnomedical Properties of Solanum Nigrum Linn (Makoi)

Goel¹,

Ahmed²,

Singh³

et al. 2022

Journal of Pharmaceutical Negative Results

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Introduction: Plants have always played a substantial role in the traditional medicine system worldwide. In India and other parts of theworld, Solanum Nigrum Linn. is one of the most promising and reliable sources of medicine in the traditional medicine system. It iswell known for its dynamic therapeutic properties. The concrete objective of selecting this plant is to consolidate its bioactive elementsand possibly medicinal qualities. So that future scientists and researchers may progress novel pharmaceuticals for pre-clinical andclinical trials, which could be launched as new targeted therapeutic options.Method: This review summarized the previous three decades' worth of scientific publications from online databases such as GoogleScholar, PubMed, ScienceDirect, Web of Science, and library books to assemble their possible phytopharmacological and therapeuticpotentials.Results: From the ongoing research database, S. Nigrum possesses a plethora of active phytoconstituents like glycoproteins,polysaccharides, polyphenolic compounds, and glycoalkaloids which are responsible for various pharmacological activities such asantioxidant, anticancer, antitumor, hepatoprotective, antidiabetic, and anti-asthmatic etc.Conclusion: This mystic herb has exhibited numerous ethnomedical properties in humans. Our research findings provide clear evidencethat S. Nigrum could be a potential natural source of several ailments and might be marketed as an alternative to contemporarymedicines. The stem, flower, root, and seed contain numerous dynamic bioactive constituents that are unexplored. Future researchershave an excellent opportunity to investigate them and elucidate their biomedical scientific activities and mechanisms in differentdiseases.

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“…A gene encoding a preprohydroxyproline-rich systemin, SnpreproHypSys, was identified from the leaves of black nightshade (Solanum nigrum) and some many other plant species that structural conformations within the peptides are recognized by the different cells/species to initiate signal transduction pathways, apparently through recognition by homologous receptor(s). To further demonstrate the biological relevance of the SnHypSys peptides, the early defense gene lipoxygenase D was shown to be induced by all three synthetic peptides when supplied to excised nightshade plant 119 . It is urgent to develop a novel quality standard to validly detect its quality.…”

Section: -O-beta-d-glucopyranoside (Ii) Pinoresinol-4-o-beta-d-glucomentioning

confidence: 99%

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2012

IJPSR

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This article reviews, connected the gap between the folkloric use of Solanum nigrum and the results of evidence based experiments. Although Solanum nigrum is a rich source of one of plants most dreaded toxins solanine, it has appreciably monstrated its potential as a reservoir of antioxidants having hepatoprotective, anti-tumor, cytostatic, anti-convulsant, anti-ulcerogenic and anti-inflammatory.effects. The review encompasses in-vitro, in vivo and clinical studies done on Solanum nigrum, while examining.whether or not correct scientific measures have been taken in generating experimental evidences for its traditional uses. This review would afford research scientist to know how much is known and what is left undone in the investigation of Solanum nigrum. The compounds considered in this revieware flavonoids and other phenolics, alkaloids (especially indole terpenoid and purine alkaloids), essential oils and other terpenoids, cannabinoids, lucosinolates and isothiocyanates, and compounds having human hormone activity. The review concludes with a discussion of the possible evolutionary mechanisms that have led to the evolution of UV-B regulation of secondary metabolite accumulation. Many Ayurveda philosophers and healers praised about the properties of this plant and utilized in various disorders. Here, a review made on the screening of Solanum nigrum for various activities. It is found that the drug is very potential and can be used for various applications as mentioned in Ayurveda. Black nightshade grows as a weed, found in the dry parts of India and other parts of the world. It has a medicinal usage and has been used as a traditional folk medicine for treating various ailments such as pain, fever and liver disorders. Generally, black nightshade is very rich in nutritive values, which are capable of supplying minerals, vitamins, hormones and proteins. This herb elaborates a wide variety of medicinal properties such as anticancer, antioxidant, neuroprotective, cytoprotective, antimicrobial, antinociceptive and antipyretic properties.

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Two novel oligosaccharides from Solanum nigrum

Cited by 10 publications

References 8 publications

Medicinal Importance of Solanum nigrum Linn; A Review

Medicinal Importance of Solanum nigrum Linn; A Review

A Sneak peek (1970-2021) Into Phytochemistry and Ethnomedical Properties of Solanum Nigrum Linn (Makoi)

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