Two novel high performing composite PMMA-CaP cements for vertebroplasty: An ex vivo animal study

Aghyarian, Shant; Hu, Xiaobang; Lieberman, Isador H.; Kosmopoulos, Victor; Kim, Harry K.W.; Rodrigues, Danieli C.

doi:10.1016/j.jmbbm.2015.06.022

Cited by 19 publications

(25 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cements investigated here were developed as described in previous studies . The cement compositions (PMMA‐HA, PMMA‐Brushite) were compared with a commercially available cement (PMMA‐K).…”

Section: Methodsmentioning

confidence: 99%

“…Recently, a pre‐mixed cement system has been reported in the literature with the versatility to be tailored for specific applications . The system can incorporate CaP fillers imparting bioactive properties upon the cement without the aforementioned detrimental effects .…”

mentioning

confidence: 99%

“…The system can incorporate CaP fillers imparting bioactive properties upon the cement without the aforementioned detrimental effects . The pre‐mixed system allows the cement to reach full swelling thus enabling the complete incorporation of CaP fillers .…”

mentioning

confidence: 99%

“…It also has superior rheological properties compared to commercial cements, making injection easier at high viscosities, thereby decreasing the risk of extravasation . The pre‐mixed system allows the cement to reach full swelling thus enabling the complete incorporation of CaP fillers . Recent studies report the performance and efficiency of two composite cements, polymethyl methacrylate‐hydroxyapatite (PMMA‐HA) and PMMA‐brushite, in an in vitro porcine vertebroplasty model .…”

mentioning

confidence: 99%

“…The pre‐mixed system allows the cement to reach full swelling thus enabling the complete incorporation of CaP fillers . Recent studies report the performance and efficiency of two composite cements, polymethyl methacrylate‐hydroxyapatite (PMMA‐HA) and PMMA‐brushite, in an in vitro porcine vertebroplasty model . These composite cements were shown to successfully stabilize the fractured porcine VBs and were able to withstand cyclic fatigue loading, however the pre‐mixed cements have not been tested using cadavers.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Biomechanical behavior of novel composite PMMA-CaP bone cements in an anatomically accurate cadaveric vertebroplasty model

Aghyarian

Haddas

et al. 2016

J. Orthop. Res.

Self Cite

View full text Add to dashboard Cite

Vertebral compression fractures are caused by many factors including trauma and osteoporosis. Osteoporosis induced fractures are a result of loss in bone mass and quality that weaken the vertebral body. Vertebroplasty and kyphoplasty, involving cement augmentation of fractured vertebrae, show promise in restoring vertebral mechanical properties. Some complications however, are reported due to the performance characteristics of commercially available bone cements. In this study, the biomechanical performance characteristics of two novel composite (PMMA-CaP) bone cements were studied using an anatomically accurate human cadaveric vertebroplasty model. The study involves mechanical testing on two functional cadaveric spinal unit (2FSU) segments which include monotonic compression and cyclical fatigue tests, treatment by direct cement injection, and microscopic visualization of sectioned vertebrae. The 2FSU segments were fractured, treated, and mechanically tested to investigate the stability provided by two novel bone cements; using readily available commercial acrylic cement as a control. Segment height and stiffness were tracked during the study to establish biomechanical performance. The 2FSU segments were successfully stabilized with all three cement groups. Stiffness values were restored to initial levels following fatigue loading. Cement interdigitation was observed with all cement groups. This study demonstrates efficient reinforcement of the fractured vertebrae through stiffness restoration. The pre-mixed composite cements were comparable to the commercial cement in their performance and interdigitative ability, thus holding promise for future clinical use. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2067-2074, 2017.

show abstract

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations