Two novel calcium delivery systems fabricated by casein phosphopeptides and chitosan oligosaccharides: Preparation, characterization, and bioactive studies

Zhu, Biyang; He, Hui; Guo, Dayong; Zhao, Mengge; Hou, Tao

doi:10.1016/j.foodhyd.2019.105567

Cited by 34 publications

(16 citation statements)

References 55 publications

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“…The bulk of the minerals present in enamel is carbonated apatite, which comprises 10 calcium ions and 6 phosphate ions. [106,107] Hydroxyapatite, being biologically compatible, has been used in various Figure 9. Synthesis of PAA-ACP@MSN and its role in remineralization of demineralized enamel.…”

Section: Ca and P Deliverymentioning

confidence: 99%

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Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

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Section: Ca and P Deliverymentioning

confidence: 99%

“…The bulk of the minerals present in enamel is carbonated apatite, which comprises 10 calcium ions and 6 phosphate ions. [ 106,107 ] Hydroxyapatite, being biologically compatible, has been used in various formulations as a biomimetic agent against dental caries [ 108 ] and dentin hypersensitivity. [ 109 ]…”

Section: Ion Deliverymentioning

confidence: 99%

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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“…The typical structures of COS showed characteristic absorption bands at 1629 cm −1 (amide I region) and 1530 cm −1 (amide II region) in FTIR spectra, attributed to N-H bending vibrations and C=O stretching vibrations, respectively. 18,21,22 The broad peak at 3424 cm −1 indicated to the stretching vibration of N-H in amine or -OH. 20 For TPP, the absorption peaks at 1213-1094 cm −1 were mainly due to the stretching vibration of P=O.…”

Section: Fourier-transform Infrared (Ftir) Analysismentioning

confidence: 99%

Preparation, investigation and storage application of thymol–chitooligosaccharide complex with enhanced antioxidant and antibacterial properties

et al. 2021

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BACKGROUND: Thymol (Thy) is a natural bioactive agent which possesses various properties and has been widely used in medicine and food industries. However, its poor bioavailability can limit its application.RESULTS: In this study, Thy was interacted with chitooligosaccharide (COS) as Thy-COS complex via an ionic crosslinking method using sodium tripolyphosphate as a crosslinker. The characteristics and thermal stability of Thy-COS were evaluated by ultraviolet-visible (UV-vis), Fourier-transform infrared (FTIR) spectroscopy, proton nuclear magnetic resonance ( 1 H-NMR) and thermogravimetric analysis, and its antioxidant and antibacterial properties were also evaluated. The highest loading capacity of Thy (52.3%) in Thy-COS formed at mass ratio of 1:5. Results indicated the Thy-COS complex was formed mainly by hydrophobic interactions and hydrogen bonds. Upon complexation, the thermal stability, antioxidant and antibacterial activity of Thy were significantly improved. Thy-COS complex was made into a coated film for Nanguo pears and greatly improved its storage quality. Thy-COS delayed the weight loss and softening of Nanguo pears and kept more vitamin-C content (2.12 mg (100 g) −1 ). CONCLUSION: In conclusion, Thy-COS was successfully prepared and improved antioxidant and antibacterial properties of Thy, which has great potential in the food industry.

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“…However, in recent years, studies on calcium supplements have been limited only to their calcium supplementation effects, probably neglecting their effects on intestinal health. It has been shown that mice intake with CaCO 3 have significantly lower abundance of Lactobacilli , short chain fatty acid (SCFA) concentration and intestinal villi area (Zhu et al., 2020). In our previous studies, desalted duck egg white peptides (DPs) were shown to be calcium absorption enhancers with high calcium‐binding capacity, and to enhance calcium absorption in vitro and in vivo (Hou et al., 2017b).…”

Section: Introductionmentioning

confidence: 99%

In vitro caecum fermentation and in vivo (Gallus gallus) of calcium delivery systems fabricated by desalted duck egg white peptides and chitosan oligosaccharide on gut health

Zhao

et al. 2021

Int J of Food Sci Tech

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As calcium supplements, two novel calcium delivery systems were prepared with desalted duck egg white peptides (DPs) and chitosan oligosaccharide (COS) by Amadori‐linkage and transglutaminase (TGase)‐induced reaction, with high calcium‐binding ability of promoting calcium absorption in vivo and in vitro. However, there are relatively few studies on the gut health of calcium delivery systems. In this experiment, in vitro caecum fermentation experiment and Gallus gallus intra amniotic feeding model were used to assess the gut health of calcium delivery systems and phytic acid. Results showed that two calcium delivery systems improved the microbial community structure by inhibiting the proliferation of Escherichia coli, and promoting the proliferation of Bifidobacterium and Lactobacillus. The addition of calcium delivery systems significantly increased short chain fatty acids (SCFAs) and improved the boundary membrane function of brush nutrients by significantly increasing villi structure, surface area, cup cell expansion and production of associated genes (P < 0.05). Moreover, calcium delivery systems present significant reverse of the inhibitory effect of phytic acid on gut health through in vitro and in vivo experiments. This study suggested that DPs‐COS‐Ca systems were superior to the commercially available calcium supplement CaCO3 and had excellent calcium absorption and gut health regulating effects.

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Two novel calcium delivery systems fabricated by casein phosphopeptides and chitosan oligosaccharides: Preparation, characterization, and bioactive studies

Cited by 34 publications

References 55 publications

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Preparation, investigation and storage application of thymol–chitooligosaccharide complex with enhanced antioxidant and antibacterial properties

In vitro caecum fermentation and in vivo (Gallus gallus) of calcium delivery systems fabricated by desalted duck egg white peptides and chitosan oligosaccharide on gut health

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