Two Novel Anti-emetic Principles of Alpinia katsumadai

Yang, Yuxiang; Kinoshita, Kaoru; Koyama, Kiyotaka; Takahashi, Kunio; Tai, Takaaki; Nunoura, Yoshiki; Watanabe, Kazuo

doi:10.1021/np990096e

Cited by 48 publications

(38 citation statements)

References 13 publications

(17 reference statements)

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“…1, the fingerprint of A. katsumadai showed the existence of eucalyptol (retention time: 7.00 min), hexadecanoic acid (retention time: 19.14 min), oleic acid (retention time: 20.57 min) and 4,6-heptadien-3-one, 1,7-diphenyl (retention time: 24.09 min), which is consistent with the results of a previous study conducted to evaluate A. katsumadai (Kuroyanagi, 1983;Yang et al, 1999).…”

Section: Discussionsupporting

confidence: 90%

“…These findings were somewhat surprising, and it is not clear which components of A. katsumadai are responsible for this highly potent inhibition. Diarylheptanoids from other Alpinia species have showed inhibitory effects against COX-2 enzyme and it has previously been reported that A. katsumadai contained diarylheptanoids, which was also confirmed by our fingerprint experiment (Yang et al, 1999) (Fig. 1).…”

Section: Discussionsupporting

confidence: 88%

“…Alpinia katsumadai is often used with other herbs such as cinnamon bark and ginger (Dong et al, 1992). The extract from A. katsumadai seeds is known to have significant antioxidant activity (Lee et al, 2003), antiemetic activity (Yang et al, 1999) and to inhibit prostaglandin production in LPS-stimulated mouse peritoneal macrophages (Noh et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Antinociceptive Effects of Alpinia katsumadai via Cyclooxygenase-2 Inhibition

Choi¹,

Kim²,

Yeom³

et al. 2010

Biomolecules and Therapeutics

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-Alpinia katsumadai has been widely used in traditional Chinese and Korean medicine to treat a variety of conditions including emesis and gastric disorders such as gastric pain and distended abdomen. To investigate the antinociceptive potential and mechanism of A. katsumadai, ethanolic extracts of A. katsumadai were assayed on cyclooxygenase-2 and evaluated for analgesic activity based on phenylbenzoquinone (PBQ)-induced writhing and carrageenan-induced hyperalgesia tests. A. katsumadai extracts inhibited the cyclooxygenase-2 enzyme activity in a dose-dependent fashion at an IC50 value of 0.044 μg/ml. A. katsumadai extract (30-300 mg/kg, orally (p.o.) administered) significantly inhibited PBQ-induced writhing. This inhibition was judged not to be a false positive because a Rota-rod test revealed no difference in muscular coordination when compared to the controls. With regard to the carrageenan-induced hyperalgesia, A. katsumadai extract (30-300 mg/kg, p.o.) produced a significant, dose-dependent increase in the withdrawal response latencies. Naloxone did not reverse the analgesic effect of A. katsumadai extract in the carrageenan-induced hyperalgesia. Taken together, these results suggest that the antinociceptive activity of A. katsumadai is not related to the opioid receptor. A. katsumadai extract has remarkable, non-opioidreceptor-mediated analgesic effects on PBQ-induced writhing and carrageenan-induced hyperalgesia that occur via cyclooxygenase-2 inhibition.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Antinociceptive Effects of Alpinia katsumadai via Cyclooxygenase-2 Inhibition

Choi¹,

Kim²,

Yeom³

et al. 2010

Biomolecules and Therapeutics

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“…Alpinia katsumadai (Zingiberaceae), which was identified by the National Plant Quarantine Service in Korea, has been used as a traditional Chinese medicine. The plant contains the following compounds: chalcone, flavonoids, diarylheptanoids, monoterpenes, sesquiterpenoids, stilbenes, and labdanes (Kimura et al, 1968;Yushiro et al, 1968;Lawrence et al, 1972;Saiki et al, 1978;Brown & Rice-Evans, 1998;Kim et al, 1998;Yang et al, 1999). It has been reported that the extract from Alpinia katsumadai seed shows cytotoxic activity against the HepG2, MCF-7 and MAD-MB-435 cell lines, and suppresses topical pruritis, and enhances antioxidant activities (Lee et al, 2003;Choi et al, 2009;Hua et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects ofAlpinia katsumadaiagainst experimental ischemic damage via control of oxidative stress

Park

Lee

et al. 2012

Pharmaceutical Biology

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“…A number of pharmacological activities of this plant extract has been reported, including antiviral activity, 16) antioxidant activity, 17) and anti-emetic effects. 18) However, there is no evidence of anti-atherosclerosis or hypolipemic effects of A. katsumadai to date.…”

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confidence: 99%

2,3,22,23-Tetrahydroxyl-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene, an Acyclic Triterpenoid Isolated from the Seeds of Alpinia katsumadai, Inhibits Acyl-CoA : Cholesterol Acyltransferase Activity

Choi

Lee

Choi

et al. 2012

Biological & Pharmaceutical Bulletin

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In order to isolate a cholesterol-lowering compound from Alpinia katsumadai, an inhibitor for acyl-CoA : cholesterol acyltransferase (ACAT), an enzyme responsible for the cholesterol ester formation in liver, was purified, its chemical structure was determined, and in vivo and in vitro inhibition activities were performed. In a high fat diet mouse model, we discovered that the ethanol extract of Alpinia katsumadai reduced plasma cholesterol, triglyceride, and low density lipoprotein (LDL) levels. An acyclic triterpenoid showing ACAT inhibitory activity was isolated from the extract of seeds of A. katsumadai. By NMR spectroscopic analysis of its 1 H-NMR, 13 C-NMR, 1 H-1 H correlation spectroscopy, heteronuclear multiple bond connectivity (HMBC), hetero multiquantum coherence (HMQC) and nuclear Overhauser effect, chemical structure of 2,3,22,23-tetrahydroxyl-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene (1), were elucidated. The acyclic triterpenoid was found to be responsible for the ACAT inhibition activities of rat liver microsomes with IC 50 values of 47.9 µM. It also decreased cholesteryl ester formation with IC 50 values of 26 µM in human hepatocyte HepG2 cell. The experimental study revealed that the ethanol extract of A. katsumadai has a hypolipemic effect in high fat diet mice, and the isolated acyclic triterpenoid has ACAT inhibition activity, showing a potential novel therapeutic approach for the treatment of hyperlipidemia and atherosclerosis.

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Two Novel Anti-emetic Principles of Alpinia katsumadai

Cited by 48 publications

References 13 publications

Antinociceptive Effects of Alpinia katsumadai via Cyclooxygenase-2 Inhibition

Antinociceptive Effects of Alpinia katsumadai via Cyclooxygenase-2 Inhibition

Neuroprotective effects ofAlpinia katsumadaiagainst experimental ischemic damage via control of oxidative stress

2,3,22,23-Tetrahydroxyl-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene, an Acyclic Triterpenoid Isolated from the Seeds of <i>Alpinia katsumadai</i>, Inhibits Acyl-CoA : Cholesterol Acyltransferase Activity

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