2018
DOI: 10.4066/biomedicalresearch.29-17-3589
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Two non-cytotoxic type 2 ribosome-inactivating proteins (Sambucus Sieboldiana lectin and Sambucus Nigra lectin) lead neurosphere cells to caspase-independent apoptosis

Abstract: We found a new phenomenon of cell damage and/or cell death of almost all types of neurosphere cells derived from telencephalons of mouse embryos. The cell damage/death was induced by non-cytotoxic type 2 ribosome-inactivating proteins: Sambucus Sieboldiana lectin (SSA) and Sambucus Nigra lectin (SNA). Self-renewal and aggregation of the neurosphere cells were inhibited under the presence of SSA or SNA. These lectins led the neurosphere cells to cell damage by making them lose their proliferation capacity. It w… Show more

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References 27 publications
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