Two new β-carboline alkaloids from the stems of Picrasma quassioides

Kwon, Hyun Sook; Lee, Hanna; Lee, Jin Soo; Lee, Ki Jun; Choi, Jung‐Hye; Jang, Dae Sik

doi:10.1007/s12272-018-1034-2

Cited by 14 publications

(8 citation statements)

References 20 publications

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“…There are a wide‐range of evidence suggesting that bioactive compounds isolated from Picrasma quassioides have significant anti‐proliferative effects on different types of cancer cells, including hepatic, ovarian, and gastric carcinomas 23–26 . Moreover, ethanol extract of Picrasma quassioides has been found to reduce the migration of H‐RAS mutated hepatic cancer cells 27 .…”

Section: Discussionmentioning

confidence: 99%

Dehydrocrenatidine inhibits head and neck cancer cells invasion and migration by modulating JNK1/2 and ERK1/2 pathway and decreases MMP‐2 expression

Velmurugan

Lin

Mahalakshmi³

et al. 2021

Environmental Toxicology

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Head and neck cancer is associated with poor prognosis because of its highly metastatic nature. For the better management of head and neck cancer patients, it is very important to diagnose the cancer at an early stage, as well as to prevent the rapid spread of cancer either through direct invasion or lymphatic metastasis. In present study, the effect of dehydrocrenatidine, which is a beta‐carboline alkaloid found in the medicinal plant Picrasma quassioides, on human head and neck cancer metastasis was investigated. The study results revealed the treatment of FaDu, SCC9, and SCC47 cells with 5, 10, and 20 μM of dehydrocrenatidine significantly decreased the motility, migration, and invasion of head and neck cancer cells. Moreover, the dehydrocrenatidine treatment significantly decreased the expression of MMP‐2 and phosphorylation of ERK1/2 and JNK1/2. Additional experiments revealed that the cotreatment of dehydrocrenatidine with either ERK1/2 or JNK1/2 inhibitor caused further reduction in cancer cell motility and migration compared to that in dehydrocrenatidine treatment alone. Moreover, similar trend was observed in case of ERK1/2 and JNK1/2 phosphorylation and MMP‐2 expression after the cotreatment. Taken together, the mechanism by which dehydrocrenatidine can decrease the phosphorylation of ERK1/2 and JNK1/2, follow decrease the expression of MMP‐2 and inhibits head and neck cancer cells invasion and migration. This present study identifies dehydrocrenatidine as a potent antimetastatic agent that can be used clinically to improve head and neck cancer prognosis.

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Section: Discussionmentioning

confidence: 99%

Dehydrocrenatidine inhibits head and neck cancer cells invasion and migration by modulating JNK1/2 and ERK1/2 pathway and decreases MMP‐2 expression

Velmurugan

Lin

Mahalakshmi³

et al. 2021

Environmental Toxicology

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“…4-Methoxy-1-vinyl-β-carboline and 1-methoxy-β-carboline are cytotoxic to A2780 and SKOV3 human ovarian cancer cells and exhibited excellent antitumor activity (67). β-carboline-1-carboxylic acid, isolated from the stem of P. quassioides, demonstrated moderate inhibitory activities against K562 leukemia cancer cells and SGC-7901 human gastric cancer cells (68) (Table VII).…”

Section: A N T I C a N C E R E F F E C T S O F β -C A Rb O L I N E A L K A L O I D Smentioning

confidence: 99%

“…However, as an Asian traditional medicine, P. quassioides exerts its effects via individual chemical components and through synergistic effects of several compounds. Modern clinical research indicated that P. quassioides has a significant effect on hypertension (32), pneumonia (67,88), dysentery (89) and other disease symptoms (90,91). Previous studies have also developed various preparations and drugs using P. quassioides, such as Kumu injection, Xiaoyan Lidan tablet (92), Fufang Kumu Xiaoyan capsule (93) and Fufang Kumu Xiaoyan tablet (94).…”

Section: Clinical Applications and Developmental Prospects Of Picrasma Quassioides (D Don) Bennmentioning

confidence: 99%

Pharmacological effects of Picrasma quassioides (D. Don) Benn for inflammation, cancer and neuroprotection (Review)

Lee¹,

Gong

Jeong³

et al. 2021

Exp Ther Med

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Picrasma quassioides (D. Don) Benn is an Asian shrub with a considerable history of traditional medicinal use. P. quassioides and its extracts exhibit good therapeutic properties against several diseases, including anti-inflammatory, antibacterial and anticancer effects. However, the composition of compounds contained in P. quassioides is complex; although various studies have examined mixtures or individual compounds extracted from it, studies on the application of P. quassioides extracts remain limited. In the present review, the structures and functions of the compounds identified from P. quassioides and their utility in anti-inflammatory, anticancer and neuroprotectant therapies was discussed. The present review provided up-to-date information on pharmacological activities and clinical applications for P. quassioides extracts.

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“…Moreover, dehydrocrenatidine ( 31 ) was effective against A2780 cells with an IC 50 of 2.02 ± 0.95 μM and against SKOV3 cells at an IC 50 of 11.89 ± 2.38 μM. Meanwhile, nigakinone ( 25 ) and methylnigakinone ( 26 ) were also effective against HepG2 cancer cells [ 3 , 55 , 56 ].…”

Section: Pharmacological Activities Of Picrasma Quassioimentioning

confidence: 99%

Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews

et al. 2020

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Picrasma quassioides is a member of the Simaroubaceae family commonly grown in the regions of Asia, the Himalayas, and India and has been used as a traditional herbal medicine to treat various illnesses such as fever, gastric discomfort, and pediculosis. This study aims to critically review the presence of phytochemicals in P. quassioides and correlate their pharmacological activities with the significance of its use as traditional medicine. Data were collected by reviewing numerous scientific articles from several journal databases on the pharmacological activities of P. quassioides using certain keywords. As a result, approximately 94 phytochemicals extracted from P. quassioides were found to be associated with quassinoids, β-carbolines and canthinones. These molecules exhibited various pharmacological benefits such as anti-inflammatory, antioxidant, anti-cancer, anti-microbial, and anti-parasitic activities which help to treat different diseases. However, P. quassioides were also found to have several toxicity effects in high doses, although the evidence regarding these effects is limited in proving its safe use and efficacy as herbal medicine. Accordingly, while it can be concluded that P. quassioides may have many potential pharmacological benefits with more phytochemistry discoveries, further research is required to determine its real value in terms of quality, safety, and efficacy of use.

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Two new β-carboline alkaloids from the stems of Picrasma quassioides

Cited by 14 publications

References 20 publications

Dehydrocrenatidine inhibits head and neck cancer cells invasion and migration by modulating JNK1/2 and ERK1/2 pathway and decreases MMP‐2 expression

Dehydrocrenatidine inhibits head and neck cancer cells invasion and migration by modulating JNK1/2 and ERK1/2 pathway and decreases MMP‐2 expression

Pharmacological effects of Picrasma quassioides (D. Don) Benn for inflammation, cancer and neuroprotection (Review)

Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews

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