Two New Tetracyclic Triterpenes from the Heartwood of Ailanthus excelsa Roxb.

Srinivas, P.; Rao, R. Ranga; Rao, J. Madhusudana

doi:10.1002/chin.200702175

Cited by 4 publications

(6 citation statements)

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“…34 The malabaricane-type triterpenes 1 and 2 were isolated from Ailanthus triphysa (synonym: Ailanthus malabarica) and A. excelsa. 28,35 Furthermore, triterpenes 3, 5, 9, and 11 were also found in Ailanthus exelsa and Ailanthus altissima plants. [35][36][37] In the book "An Illustrated Vietnamese Flora," Ho reported 4 Ailanthus species in Vietnam, among which Ailanthus triphysa was distributed in Binh Dinh and neighboring provinces.…”

Section: Compound Identification and Plant Sourcesmentioning

confidence: 96%

Chemical Constituents, Cytotoxicity, and Molecular Docking Studies of Tetragonula iridipennis Propolis

Phuong,

Cong,

Phuong

et al. 2023

Natural Product Communications

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Objective: Propolis of Tetragonula iridipennis, which is one of the most popular stingless bees found in Vietnam, has been used to promote health and prevent disease. This study aims to identify the chemical constituents of T iridipennis propolis and their cytotoxic activity. Methods: The propolis sample was extracted with ethanol. The crude extract was isolated by combined chromatographic methods. The structures of isolated compounds were determined by electrospray ionization mass spectrometry and nuclear magnetic resonance spectra. The cytotoxicity was evaluated by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide method. The protein interactions of active compounds were explored by molecular docking study. Results: Sixteen known compounds, including 11 triterpenes, 3 xanthones, a sterol, and a flavonoid were isolated and identified. The propolis ethanol extract displayed good cytotoxicity against A-549 and KB cancer cell lines. 24 S,25-Dihydroxytirucall-7-en-3-one was the most active compound with IC50 values ranging from 18.75 ± 0.21 to 19.62 ± 0.36 µg/mL. Conclusions: Sixteen known constituents were identified from T. iridipennis propolis, of which 8 compounds were discovered for the first time. The propolis of T iridipennis has multiple sources of plant resin, among that Ailanthus triphysa (Simaroubaceae) was identified as a new plant source. A molecular docking study revealed that cytotoxic effects of 24 S,25-dihydroxytirucall-7-en-3-one, α-mangostin, 6-methoxy–bispyrano xanthone, and 3-isomangostin related to the inhibition of all 3 targets epidermal growth factor receptor, human epidermal growth factor receptor 2, and mammalian target of rapamycin (mTOR), while other isolated triterpenes exert their cytotoxicity by the inhibition of mTOR protein activity.

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Section: Compound Identification and Plant Sourcesmentioning

confidence: 96%

Chemical Constituents, Cytotoxicity, and Molecular Docking Studies of Tetragonula iridipennis Propolis

Phuong,

Cong,

Phuong

et al. 2023

Natural Product Communications

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“…Ailexcelone was moderately active against Aspergillus niger and Rhizopus oryzae with an inhibition zone diameter of 12 mm at 100 lg/ml. Ailexcelol also displayed a moderate degree of activity against Aspergillus niger and Candida albicans with an inhibition zone diameter of 10 and 11 mm, respectively (Srinivas et al 2006). Joshi et al (2003b) studied the anti-fungal activity of A. excelsa.…”

Section: Anti-bacterial and Anti-fungal Activitymentioning

confidence: 98%

A brief resume on the genus Ailanthus: chemical and pharmacological aspects

Kundu

Laskar

2009

Phytochem Rev

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Over the past decade, herbal medicine has become an item of global importance, with both medicinal and economic implications. Thus, accurate scientific assessment has become a prerequisite for acceptance of herbal health claims. The plants of genus Ailanthus, belong to the family Simaroubaceae, is widely used in Ayurveda and evidence-based phytotherapy. Several species of the genus Ailanthus are widely distributed over Asia and north Australia and studied extensively over the last few decades. A compilation of the constituents isolated from different Ailanthus species covering the literature up to December 2008 is presented in the review. The botanical classification and ethno-pharmacology of Ailanthus plants, as well as the biological activities and pharmacological applications of both distinct phytochemicals and active plant materials (formulations, extracts etc.), are discussed in detail.

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“…10 was more toxic (4.92%) and its activity was 425 comparable to that of polymyxin. It was reported earlier to 426 have antiplasmodial activity but also caused transformation of 427 erythrocytes into stomatocytes [21]. Interestingly, 5 which is 428 structurally related to 10 (opening of epoxy ring in 10 results in 429 5) was found to be least toxic (1.84%).…”

mentioning

confidence: 94%

“…Even the latest report on the identification of malabaricol and 360 epoxymalabaricol isolated from the heartwood of Ailanthus 361 excelsa does not contain the NMR data and assignments [21]. no mention of how it was arrived at [7].…”

mentioning

confidence: 96%