Two new test methods to quantify motor deficits in a marmoset model for Parkinson's disease

Verhave, Peternella S.; Vanwersch, R.A.P.; Helden, H.P.M. van; Smit, August B.; Philippens, Ingrid H.C.H.M.

doi:10.1016/j.bbr.2009.01.022

Cited by 41 publications

(34 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, in a previous study, a specific marmoset behavior (head-cocking) was reported to occur on day 13 after birth and reach a stable level by days 24-29 [9] , over the same developmental period as our study. Motor performance has also been studied in several marmoset disease models, such as PD [10] , spinal cord injury [11] , stroke [12] , and aging models [13] . In the future, marmosets could be further used for developing models of other motor-related human diseases, such as transgenic models for motor-related genes.…”

Section: Discussionmentioning

confidence: 99%

Motor assessment of developing common marmosets

2014

View full text Add to dashboard Cite

Motor development has been extensively studied in human infants and children, with several established scales for the evaluation of motor functions. However, the study of the neuronal mechanisms underlying human motor development is hampered by the lack of good animal models. The common marmoset (Callithrix jacchus), a small New World monkey, has recently attracted much attention as a potential nonhuman primate model for understanding human physiology and diseases. However, little is known about its gross motor development. In the present study, we found that marmosets have a critical period for motor development in postnatal weeks 2 to 5, and acquire most of their motor skills by 8 weeks of age. We also developed methods to assess their motor functions, which will be useful for the evaluation of motor performance in marmoset models of human diseases. In addition, we found that marmosets exhibit a "head-to-tail" sequence of motor development similar to that found in humans, further supporting the notion that they provide a good animal model for studying the neuronal mechanisms underlying human motor development.

show abstract

Section: Discussionmentioning

confidence: 99%

Motor assessment of developing common marmosets

2014

View full text Add to dashboard Cite

show abstract

“…Together, these insights may contribute to the development of therapeutic approaches aiming at the preservation of myelin under pathological conditions that affect lipid metabolism. extracellular environment ( 51,52,150 ). This is, however, complicated by the blood-nerve barrier and the bloodbrain barrier that shield, respectively, the PNS and CNS from lipids in the circulation ( 151,152 ).…”

Section: Myelin Lipids Provide Direct Support To Axonal Function; a Hmentioning

confidence: 99%

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models

Chrast

Saher

Nave

et al. 2011

Journal of Lipid Research

242

244

View full text Add to dashboard Cite

“…3A) to which it had been habituated (see Verhave et al, 2009). The tower had a transparent front so that the animal could be t=-0.03 t=-0.04 t=-0.05 t=-0.06 t=-0.07 t=-0.08 t=-0.09 t=-0.10 t=0 t=-0.01 t=-0.02 0.10 m Fig.…”

Section: Recording Of Jumpsmentioning

confidence: 99%

Mechanical output in jumps of marmosets (Callithrix jacchus)

Bobbert

Plas

Weide

et al. 2013

Journal of Experimental Biology

View full text Add to dashboard Cite

In this study we determined the mechanical output of common marmosets (Callithrix jacchus) during jumping. Vertical ground reaction forces were measured in 18 animals while they jumped from an instrumented crossbar to a crossbar located 70 cm higher. From the vertical force time histories, we calculated the rate of change of mechanical energy of the centre of mass (dE/dt). The mean value of dE/dt during the push-off amounted to 51.8±6.2 W kg −1 body mass, and the peak value to 116.4±17.6 W kg −1 body mass. We used these values in combination with masses of leg muscles, determined in two specimens, to estimate mean and peak values of dE/dt of 430 and 970 W kg −1 muscle, respectively. These values are higher than values reported in the literature for jumps of humans and bonobos, but smaller than those of jumps of bushbabies. Surprisingly, the mean value of dE/dt of 430 W kg −1 muscle was close to the maximal power output of 516 W kg −1 muscle reported in the literature for isokinetic contractions of rat medial gastrocnemius, one of the fastest mammalian muscles. Further study of the force-velocity relationship of muscle tissue of small primates is indicated. KEY WORDS: Biomechanics, Muscle power, Muscle work, Mass-specific, Primates INTRODUCTIONOne of the challenging goals in movement science is to relate the total mechanical output of an animal during locomotor tasks to the output of the elements of the musculoskeletal system. The limits of mechanical output are approached in jumping, a locomotor task that is important for survival in many animals because it plays a role in catching prey or escaping from predators. Many studies have been conducted on the mechanics of jumping of various species (Aerts, 1998;Bobbert, 2001;Harris and Steudel, 2002;Henry et al., 2005;Peplowski and Marsh, 1997;Roberts et al., 2011;Scholz et al., 2006). In humans, the mechanical output in jumping has been successfully reproduced and analyzed with the help of musculoskeletal models (Bobbert, 2001;Bobbert and van Soest, 2001;Nagano et al., 2005;Pandy et al., 1990). However, humans are relatively poor jumpers compared with nonhuman primates such as bonobos (Scholz et al., 2006), gibbons (Channon et al., 2012) and bushbabies (Aerts, 1998). The jumping performance of small primates is especially puzzling. If a human musculoskeletal model is downscaled to the size of a 0.3 kg bushbaby, jump height drops from ~40 cm to ~10 cm (Bobbert, 2013). It is easy to understand why jump height does not remain constant with geometric downscaling: for jump height to remain constant, the vertical take- off velocity of the centre of mass (COM) must remain constant, but with shorter segments this would require higher angular velocities and hence higher muscle shortening velocities, and at higher shortening velocities muscle mechanical output would be hampered more by the force-velocity relationship (Bobbert, 2013). If small primates are able to jump higher than humans, their bodies must be anatomically and physiologically different from those of huma...

show abstract

Two new test methods to quantify motor deficits in a marmoset model for Parkinson's disease

Cited by 41 publications

References 40 publications

Motor assessment of developing common marmosets

Motor assessment of developing common marmosets

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models

Mechanical output in jumps of marmosets (Callithrix jacchus)

Contact Info

Product

Resources

About