Two New Stereoisomers of Neolignan and Lignan from the Flower Buds of <i>Magnolia fargesii</i>

Scopoletin from the flower buds of Magnolia fargesii inhibits protein glycation, aldose reductase, and cataractogenesis Ex Vivo

“…Thus further biological studies will be needed on these two active compounds for the discovery of diabetic complications preventive agents. In addition, these biological data as well as our previous studies (Lee et al, , 2009) on this species supported that the flower buds of M. fargesii would be considered as good medicinal source for diabetic complications. 72.87 ± 12.40 a All opacities were analyzed from each lens.…”

“…Previous studies revealed that this medicinal source contains several phytochemicals such as lignans, neolignans, sesquiterpenes, and essential oils, which display the biological activities such as anti-platelet-activating factor (PAF), anti-TNFα, and calcium antagonism (Pan et al, 1987;Chen et al, 1988;Chae et al, 1998;Jung et al, 1998;Cho et al, 1999). In our previous study, we have reported several lignans and neolignans with diabetic complications-associated biological activities including superoxide radical scavenging and aldose reductase inhibitory (Lee et al, , 2009. In this study, five known compounds (1-5) of various structural types were further isolated from the flower buds of M. fargesii in our continuous research to discover preventive agents for diabetic complications from herbal medicines.…”

Neolignan inhibitors of antigen-induced degranulation in RBL-2H3 cells from the needles of Pinus thunbergii

“…J = 8.0 Hz) of threo configuration [24,25]. The absolute configurations of C-7 and C-8 were confirmed, by a negative cotton effect at 236 nm in the CD spectrum, as being 7S and 8R configuration [26,27].…”

“…Compound 1 was isolated as an amorphous powder, and its molecular formula was assigned as C 25 ]. Acid hydrolysis of 1 yielded rhamnose as the sugar residue, which were confirmed by both TLC and PC co-chromatography with authentic sample.…”

Four New Monoterpenoid Glycosides from the Flower Buds of Magnolia biondii

“…Its volatile oil has also been processed into all kinds of cosmetics which are widely used in China [4]. It has been reported to possess extensive anti-allergy [5,6], anti-inflammatory [7], anti-angiogenic [8], anti-platelet aggregation [9,10], antimicrobial [11] and antioxidant activities [12,13]. Several types of compounds have been isolated from the plant, including lignans [9], neolignans [9], sesquiterpenoids [14], alkaloids [15,16], and flavonoids [15,16].…”