Two new sesquiterpenoids and one new p-coumaroyl-triterpenoid derivative from Myrcia guianensis

Fehlberg, Isley; Ribeiro, Paulo R.; Santos, Iago B.F. dos; Santos, Ismirna I.P. dos; Guédès, Michel; Ferraz, Caline G.; Cruz, Frederico G.

doi:10.1016/j.phytol.2022.01.005

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…The Myrtaceae family is comprised of approximately 132 genera and over 6000 tree and shrub species [ 10 , 11 , 12 ], and in Brazil, we can find 29 genera and 1192 species [ 13 ]. Recent studies show that EOs from the Myrtaceae family have a great potential to solve problems in several industries, such as health, food, and even agricultural production [ 14 ], as they have important properties, including antioxidant, insecticide, parasiticide, antimicrobial [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profile and Herbicidal (Phytotoxic), Antioxidants Potential of Essential Oils from Calycolpus goetheanus (Myrtaceae) Specimens, and in Silico Study

et al. 2022

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The essential oil (EO) of Calycolpus goetheanus (Myrtaceae) specimens (A, B, and C) were obtained through hydrodistillation. The analysis of the chemical composition of the EOs was by gas chromatography coupled with mass spectrometry CG-MS, and gas chromatography coupled with a flame ionization detector CG-FID. The phytotoxic activity of those EOs was evaluated against two weed species from common pasture areas in the Amazon region: Mimosa pudica L. and Senna obtusifolia (L.) The antioxidant capacity of the EOs was determined by (DPPH•) and (ABTS•+). Using molecular docking, we evaluated the interaction mode of the major EO compounds with the molecular binding protein 4-hydroxyphenylpyruvate dioxygenase (HPPD). The EO of specimen A was characterized by β-eudesmol (22.83%), (E)-caryophyllene (14.61%), and γ-eudesmol (13.87%), while compounds 1,8-cineole (8.64%), (E)-caryophyllene (5.86%), δ-cadinene (5.78%), and palustrol (4.97%) characterize the chemical profile of specimen B’s EOs, and specimen C had α-cadinol (9.03%), δ-cadinene (8.01%), and (E)-caryophyllene (6.74%) as the majority. The phytotoxic potential of the EOs was observed in the receptor species M. pudica with percentages of inhibition of 30%, and 33.33% for specimens B and C, respectively. The EOs’ antioxidant in DPPH• was 0.79 ± 0.08 and 0.83 ± 0.02 mM for specimens A and B, respectively. In the TEAC, was 0.07 ± 0.02 mM for specimen A and 0.12 ± 0.06 mM for specimen B. In the results of the in silico study, we observed that the van der Waals and hydrophobic interactions of the alkyl and pi-alkyl types were the main interactions responsible for the formation of the receptor–ligand complex.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Profile and Herbicidal (Phytotoxic), Antioxidants Potential of Essential Oils from Calycolpus goetheanus (Myrtaceae) Specimens, and in Silico Study

et al. 2022

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“…Halogenated natural products are produced mainly by marine organisms living in halogen-rich environments, or by microorganisms such as algae, cyanobacteria, and fungus [26][27][28][29][30][31]. Although rarely isolated from terrestrial plants, several plant-derived natural products containing halogen, usually chlorine, have been reported [32][33][34][35]. However, some of these compounds could be artifacts that are produced when halogenated solvents are used.…”

Section: Resultsmentioning

confidence: 99%

Unusual Vilasinin-Class Limonoids from Trichilia rubescens

Amuti,

Saito,

Fukuyoshi

et al. 2024

Molecules

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Eight vilasinin-class limonoids, including the unusually chlorinated rubescins K–M (1–3), the 2,3-epoxylated rubescin N (4), and rubescins O–R (5–8), were newly isolated from Trichilia rubescens. The structures of the isolated compounds were determined through spectroscopic and spectrometric analyses, as well as ECD calculations. The natural occurrence of chlorinated limonoids 1–3 was confirmed by chemical methods and HPLC analysis of a roughly fractionated portion of the plant extract. Eight selected limonoids, including previously known and new compounds, were evaluated for antiproliferative activity against five human tumor cell lines. All tested limonoids, except 8, exhibited significant potency, with IC50 values of <10 μM; in particular, limonoid 14 strongly inhibited tumor cell growth, with IC50 values of 0.54–2.06 μM against all tumor cell lines, including multi-drug-resistant cells.

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