Two new sesquiterpenes from the fruits of Fissistigma villosissimum

Abstract

Two new sesquiterpenes, namely fissistinone (1) and fissistinol (2), along with ten known compounds (3-12), were isolated from the fruits of Fissistigma villosissimum. Their structures were elucidated on the basis of spectral data analysis, including one-dimensional (1D), two-dimensional (2D)-nuclear magnetic resonance (NMR), and high-resolution-electrospray ionization-mass spectrometry (HR-ESI-MS). Compounds 1-8 were evaluated for their cytotoxic activities against KB cell line; however, all these compounds did not show cytotoxic activity.

Isolation and Characterization of Sesquiterpenoids from Cassia Buds and Their Antimicrobial Activities

“…A total of 10 known sesquiterpenoids were identified to be 1β,7-dihydroxyl opposit-4(15)-ene ( 3 ), 1β,11-dihydroxyl opposit-4(15)-ene ( 4 ), 4(15)-eudesmene-1β,7,11-triol ( 5 ), 1β,6α-dihydroxyeudesm-4(15)-ene ( 6 ), caryolane-1,9β-diol ( 7 ), 4α-10α-dihydroxy-5β- H -guaja-6-ene ( 8 ), 1β,4β,11-trihydroxyl-6β-gorgonane ( 9 ), aromadendrane-4β,10α-diol ( 10 ), aromadendrane-4α,10α-diol ( 11 ), and 1- epimer -aromadendrane-4β,10α-diol ( 12 ), by the spectroscopic data analyses, including NMR and HRESIMS, and a comparison to those in the literature.…”

Fissistigma genus – a review on phytochemistry and pharmacological activities

“…Orientin R 1 =glc; R 3 =R 4 =H; R 6 =R 2 =R 5 =OH 5 (Chen et al 2018) (Porzel et al 2000) 203 Fissistigmatin B (Porzel et al 2000) 204 Fissistigmatin C (Porzel et al 2000) 205 Fissistigmatin D (Porzel et al 2000) glucopyranoside 219 Shikimic acid (Tran et al 2017) 220 (1S*, 2R*, 4R*, 7R*, 10R*)-1,7,10,11-tetrahydroxy-1,7,11trimethyl-4,10(H)-2-O-cinnamoylbisabol-8(9)-ene (Thao et al 2009) 221 Methyl elaidate (Thao et al 2009)…”