Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and α-glucosidase inhibitory activities

Yang, Fei; H, Shi; Zhang, Xiaowei; Yang, Haisha; Zhou, Qin; Yu, Liangli

doi:10.1016/j.foodchem.2013.06.015

Cited by 53 publications

(27 citation statements)

References 21 publications

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“…Sinensitin merupakan senyawa metoksi flavonoid larut kloroform dengan aktivitas anti α-glukosidase kuat (IC 50 0,66 mg/mL) (Mohamed et al, 2012). Aktivitas penghambatan α-glukosidase oleh fraksi butanol kumis kucing belum pernah dilaporkan akan tetapi senyawa glikosida dan flavonoid dengan aktivitas anti α-glukosidase kuat diisolasi dari fraksi butanol herbal Gynostemma pentaphyllum (Yang et al, 2013). Kumis kucing dilaporkan mengandung senyawa glikosida termasuk saponin (Siddiqui et al, 2009).…”

Section: Hasil Dan Pembahasan Aktivitas Penghambatan α-Glukosidase Ekunclassified

SENYAWA INHIBITOR Α-Glukosidase DAN ANTIOKSIDAN DARI KUMIS KUCING DENGAN PENDEKATAN METABOLOMIK BERBASIS FTIR

Juliani

Yuliana

Budijanto

et al. 2016

jtip

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Plant is well known as an excellent source for b ioactive compounds. Metab olomics was reported as a potential tool to accelerate plant acitive compounds identification. In this research, FTIR-b ased metab olomics method was used to identify active compounds with α-glucosidase inhib itory and antioxidant activity in aerial parts of Orthosiphon stamineus (OS OPLS). Based on the VIP (variab le influence on projection), the coefficient value of the respective OPLS models, and IR datab ase of compounds previously identified in OS, it was suggested that methoxy flavonoid (sinensitin and 5,6,7,3'-tetramethoxy-4'-hydroxy-8-C-preny-lflavone), diterpenes (orthosiphols, orthoarisins, neoorthosiphols, staminols, and stam inolactones) and triterpenes (ursolic acid, oleanolic acid, b etulinic acid, hydroxyb etulinic acid, maslinic acid, α-amyrin and β-amyrin) were identified as responsib le compounds for the α-glucosidase inhibitory activity. Meanwhile phenolic (rosmarinic acid ), methoxy flavonoid (eupatorin, sinensetin, 5-hydroxy-6,7,3',4'-tetramethoxyflavone, salvigenin, 6-hydroxy-5,7,3'-trimethoxyflavone and 5,6,7,3'-tetramethoxy-4'-hydroxy-8-C-prenylflavone), diterpenes (orthosiphols, orthoarisins, neoorthosiphols, staminols, and staminolactones) and triterpenes (ursolic acid, oleanolic acid, b etulinic acid, hydroxyb etulinic acid, maslinic acid, α-amyrin and β-amyrin) were identified as responsib le compounds for the antioxidant activity. Keywords: α-glucosidase inhib itors, antioxidants, metab olomics, Orthosiphon stamineus ABSTRAK1Tumbuhan merupakan salah satu sumber senyawa aktif yang potensial. Pendekatan metabolomik dilaporkan sebagai salah satu metode alternatif yang dapat mempercepat proses identifikasi komponen aktif dari tumbuhan. Pada penelitian ini, metode metabolomik berbasis FTIR digunakan untuk meng-identifikasi senyawa aktif dengan aktivitas penghambatan terhadap enzim α-glukosidase dan antioksidan pada ekstrak dan fraksi tanaman kumis kucing (OS). Profil kimia ekstrak metanolik dan fraksi heksana, kloroform, butanol, dan air OS diukur dengan FTIR. Ekstrak dan fraksi OS menunjukkan aktivitas penghambatan terhadap enzim α-glukosidase dengan nilai IC50 berkisar 154,07±30,60-465,83±85,34 µg/mL dan aktivitas antioksidan dengan nilai IC50 berkisar 7,41±0,02-19,35±0,09 µg/mL. Fraksi butanol adalah fraksi dengan aktivitas penghambatan α-glukosidase tertinggi dan aktivitas antioksidan menengah dengan nilai IC 50 berturut-turut turut 154,07±30,60 µg/mL dan 10,84±0,54 µg/mL. Korelasi antara data aktivitas biologis dan komposisi kimia dianalisis dengan orthogonal projections to latent structures (OPLS). Berdasarkan nilai VIP (variab le influence on projection), nilai koefisien dari model OPLS, dan pangkalan data IR senyawa yang telah teridentifikasi pada OS. Metoksi flavonoid (sinensitin dan 5,6,7,3'-tetrametoksi-4'-hidroksi-8-C-prenilflavon), diterpena (ortosifol, ortoarisin, neoortosifol, staminol, dan staminolakton), triterpena (asam ursolat, asam oleanolat, asam betulinat, asam hidroksibetulinat, ...

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Section: Hasil Dan Pembahasan Aktivitas Penghambatan α-Glukosidase Ekunclassified

SENYAWA INHIBITOR Α-Glukosidase DAN ANTIOKSIDAN DARI KUMIS KUCING DENGAN PENDEKATAN METABOLOMIK BERBASIS FTIR

Juliani

Yuliana

Budijanto

et al. 2016

jtip

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“…Triterpenoid saponins are glycosylated plant secondary metabolites, which have been reported to possess many important biological and pharmacological activities [30][31][32][33]. In our research program for potent and effective antidiabetic agents, carbohydrate-based modifications on natural products (especially triterpenoid saponins) were carried out.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of a Series of Oleanolic Acid Saponins as α‐Glucosidase and α‐Amylase Inhibitors

Guo

et al. 2015

Archiv der Pharmazie

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Sixteen naturally occurring oleanolic acid saponins and their derivatives were synthesized in an efficient and practical strategy, and their inhibitory activities against α-glucosidase and α-amylase were evaluated in vitro. Among all the compounds, 28-O-monoglucoside 8 exhibited remarkably potent inhibitory activity against α-glucosidase with an IC50 value of 87.3 µM, which was fivefold stronger than that of the antidiabetic acarbose. Based on the preliminary structure-activity relationships, for 28-O-monoglucosides, the presence of a terminal α-l-rhamnopyranosyl residue enhanced the α-glucosidase and α-amylase inhibitory activities. Furthermore, for 3,28-O-bidesmosides, sugar-substituted moieties attached to the C-3 and C-28 positions of the oleanolic acid scaffold are helpful to increase the inhibitory activities against α-amylase and α-glucosidase.

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“…Available literature has revealed the role of these phytochemicals in treatment of inflammation and associated problems (Liu and Lin. 2012;Piwowarski et al, 2011;Yang et al, 2013;Nalbantsoy et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory, analgesic and anti-pyretic activities of standardized root extract of Jasminum sambac

Sengar

Joshi

Prasad

et al. 2015

Journal of Ethnopharmacology

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Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and α-glucosidase inhibitory activities

Cited by 53 publications

References 21 publications

SENYAWA INHIBITOR Α-Glukosidase DAN ANTIOKSIDAN DARI KUMIS KUCING DENGAN PENDEKATAN METABOLOMIK BERBASIS FTIR

SENYAWA INHIBITOR Α-Glukosidase DAN ANTIOKSIDAN DARI KUMIS KUCING DENGAN PENDEKATAN METABOLOMIK BERBASIS FTIR

Synthesis and Evaluation of a Series of Oleanolic Acid Saponins as α‐Glucosidase and α‐Amylase Inhibitors

Anti-inflammatory, analgesic and anti-pyretic activities of standardized root extract of Jasminum sambac

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