Two new phenylpropanoid glycosides from the aerial parts of Lespedeza cuneata

Abstract

Two new phenylpropanoid glycosides named cuneataside E (1) and cuneataside F (2), were isolated from the aerial parts of Lespedeza cuneata (Dum. Cours.) G. Don, whose structures were E and Z isomer, respectively. Their structures were elucidated on the basis of comprehensive spectroscopic analysis (UV, IR, HR-ESI-MS, 1D and 2D NMR). In in vitro bioassays at 10 μmol/L, compound 1 showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HeG2 cells.

Phytochemical Constituents Identified from the Aerial Parts of Lespedeza cuneata and Their Effects on Lipid Metabolism during Adipocyte Maturation

“…It is generally distributed throughout Korea, China, and India [3]. As an important Korean medicinal plant, L. cuneata has been applied in traditional folk medicines to treat liver, kidney, and lung disorders and other diseases, such as diabetes, hematuria, and insomnia [4,5]. Previous studies on this plant for its pharmacological properties have reported that the extracts of L. cuneata have antidiabetic and hepatoprotective activities [3,4,6,7].…”

“…As an important Korean medicinal plant, L. cuneata has been applied in traditional folk medicines to treat liver, kidney, and lung disorders and other diseases, such as diabetes, hematuria, and insomnia [4,5]. Previous studies on this plant for its pharmacological properties have reported that the extracts of L. cuneata have antidiabetic and hepatoprotective activities [3,4,6,7]. Some studies revealed that the extracts of L. cuneata showed pharmacological properties such as protection against testicular and ovarian diseases [8,9].…”

Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of Lespedeza cuneata and Their Biological Evaluations

“…This plant has been used in folk medicine for the treatment of diseases, including diabetes, hematuria, and insomnia, as well as for the protection of the kidneys, liver, and lungs [ 2 , 3 ]. Previous pharmacological studies of this medicinal plant have revealed that extracts of L. cuneata exhibit inhibition of inflammatory mediators in Lipopolysaccharide (LPS)-activated RAW264.7 cells and paw edema in carrageenan-stimulated rats [ 4 ], as well as hepatoprotective and antidiabetic effects [ 1 , 2 , 5 , 6 ]. A recent study of L. cuneata extract reported its in vitro cytotoxic effects against several cancer cell lines including HeLa, Hep3B, A549, and Sarcoma180 [ 7 ].…”

“…A recent study of L. cuneata extract reported its in vitro cytotoxic effects against several cancer cell lines including HeLa, Hep3B, A549, and Sarcoma180 [ 7 ]. In terms of phytochemical components, it is a rich source of various compounds such as steroids, flavonoids, phenolics [ 3 , 6 , 8 ], phenylpropanoids [ 2 , 9 ], lignans [ 5 , 9 ], and phenyldilactones [ 10 ]. Among the constituents, lignans, and flavonoids are the main components of L. cuneata , and the lignans were found to have hepatoprotective [ 5 ] and anti-ulcerative colitis activities [ 9 ], and the flavonoids were reported to show hepatoprotective [ 6 ] and NO-inhibitory effects [ 11 ].…”