Two new monoterpene esters from Illigera paviflora Dunn roots

Abstract

Two new monoterpenes, illigerates H and I (1 and 2), and six known compounds actinodaphine (3), bulbocupnine (4), stephanine (5), hypserpanine B (6), betulinic acid (7) and gallic acid (8) were obtained from the root of Illigera paviflora Dunn.Their structures were elucidated by spectroscopic analysis. Anti-inflammatory and αglucosidase inhibitory activity of some isolated compounds were assessed. Two monoterpenes 1 and 2 exhibited weak in vitro anti-inflammatory activity (IC 50 64.5 ± 5.3 and 79.2 ± 7.5 μM) while compounds 3 -6 showed inhibition of α-glucosidase with IC 50 values ranged from 87.17 to 118.74 μM.

Advances in the natural α‐glucosidase inhibitors

“…Actinodaphine, bulbocupnine, stephanine, and hypserpanine B which have the aporphine alkaloid structure in the isoquinoline alkaloid group, exhibited potent hypoglycemic activity with IC 50 values of 101.7, 87.2, 118.7, and 117.8 µM, respectively, while acarbose had an IC 50 value of 246.8 µM (Jiang et al, 2022).…”