Two new glycosides from <i>Dryopteris fragrans</i> with anti-inflammatory activities

Peng, Bing; Bai, Ruifeng; Li, Ping; Han, Xiao; Wang, Hong; Zhu, Chong-Chong; Zeng, Zhi-Gui; Chai, Xingyun

doi:10.1080/10286020.2015.1121853

Cited by 26 publications

(21 citation statements)

References 4 publications

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“…D. fragrans has been used as folk medicine for treating arthritis and skin diseases such as psoriasis, dermatophytosis, and more [ 3 ]. Previous phytochemical investigations on this plant have led to the identification of terpenoids [ 4 ], phloroglucinols [ 5 ], glucosides [ 6 ], and other phenolic derivatives such as coumarin [ 3 ]. The earlier biological studies have shown that D. fragrans was a valuable medicinal plant resource with extensive biological activities including anti-cancer, anti-oxidation, insect repellent, anti-microbial, and anti-inflammation activities [ 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott

et al. 2018

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Dryopteris fragrans is a valuable medicinal plant resource with extensive biological activities including anti-cancer, anti-oxidation, and anti-inflammation activities. This work aims to study further the cytotoxic constituents from Dryopteris fragrans. In this work, two new phenolic derivatives known as dryofragone (1) and dryofracoumarin B (2) with six known compounds (3–8) were isolated from the petroleum ether fraction of the methanol extract of the aerial parts of Dryopteris fragrans (L.) Schott by two round cytotoxicity-guided tracking with the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and cell counting kit-8 (CCK-8) assay. Their structures were elucidated by the extensive spectroscopic analysis (1H-NMR, 13C-NMR, and two dimensions NMR), chemical derivatization, and comparison with data reported in the literature. All the isolates were evaluated for their cytotoxicity against nine cancer cell lines as well as their in vitro immunomodulatory activity. The results showed that compounds have a modest cytotoxicity toward human HeLa cell line with IC50 value below 30 μM and compounds 4 and 5 may modulate immunity to affect the growth of tumor cells.

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott

et al. 2018

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“…[ 1 , 2 ]. The chemical components isolated from D. fragrans have exerted many biological effects [ 3 , 4 , 5 , 6 ]. In recent years, there have been many studies regarding the anticancer components of D. fragrans .…”

Section: Introductionmentioning

confidence: 99%

Anticancer Phenolics from Dryopteris fragrans (L.) Schott

et al. 2018

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Cancer is one of the most major diseases that threatens human health and life. The aim of this work was to obtain novel anticancer molecules from D. fragrans, a kind of medicinal plant. The structure of the new compound was identified using spectroscopic data (1H-NMR, 13C-NMR and two dimensions NMR). Its anticancer properties were evaluated using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay against four human cells including lung cancer cells (A549), breast cancer cells (MCF-7), gastric cancer cells (SGC7901) and noncancerous human umbilical vein endothelial cells (HUVEC). A new phenylpropanoid—(E)-caffeic acid-9-O-β-d-xylpyranosyl-(1→2)-β-d-glucopyranosyl ester (1), with seven known compounds (2–8)—was isolated. The IC50 value of compound 1 against MCF-7 cells was 2.65 ± 0.14 µM, and the IC50 values of compound 8 against three cancer cells were below 20 µM.

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“…Earliert his year,anew chromone glycoside knowna sf rach-romoneC (33;F igure 21), isolatedf rom Dryopteris fragrans (L.) Schott,w as found to inhibit CNO production. [57] In another recentr esearch effort, ac hloride-substituted 2-(2-phenethyl)chromone 34 (GYF-17; Figure 21) showedi nhibitory activity toward CNO synthesis. [58] The results also showedt hat this inhibitory activity is due to the suppression of iNOS expression, with consequent decrementi nCNO production.…”

Section: Cno Production Inhibitorsmentioning

confidence: 98%

Chromones: A Promising Ring System for New Anti‐inflammatory Drugs

2016

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The quest for safer anti-inflammatory drugs is still the focus of several medicinal chemistry programs. Chromones (4H-chromen-4-ones) are a group of naturally occurring compounds ubiquitous in plants, and the chromone core has proven to be a privileged scaffold in medicinal chemistry. Herein we provide an overview of the relevance of chromones as anti-inflammatory agents, specifically as inhibitors of cyclooxygenase (COX), 5-lipoxygenase (5-LOX), interleukin-5 (IL-5), and nitric oxide ( NO) production. Numerous structure-activity relationships and mechanisms of action are discussed. This review is therefore intended to provide a foundation for the design and synthesis of novel chromone-based compound libraries for further development into safer and more efficient anti-inflammatory agents.

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Two new glycosides from Dryopteris fragrans with anti-inflammatory activities

Cited by 26 publications

References 4 publications

Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott

Cytotoxicity-Guided Isolation of Two New Phenolic Derivatives from Dryopteris fragrans (L.) Schott

Anticancer Phenolics from Dryopteris fragrans (L.) Schott

Chromones: A Promising Ring System for New Anti‐inflammatory Drugs

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