Two new furostanol glycosides from Asparagus cochinchinensis (Lour.) Merr.

Jian, Rui; Tu, Pengfei

doi:10.5246/jcps.2013.02.029

Cited by 4 publications

(1 citation statement)

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“…The structures of 1 – 6 were assigned from spectroscopic evidence, and the absolute configurations of kalshinoids A, B, E, and F were determined by electronic circular dichroism (ECD) calculations. The 21 known compounds were identified as 4α,7α-epoxyguaiane-10α,11-diol ( 7 ), ent -4(15)-eudesmene-1β,6α-diol ( 8 ), pubescone ( 9 ), schensianol A ( 10 ), hydroxylindestenolide ( 11 ), lβ-hydroxy-β-cyperone ( 12 ), 10-hydroxy-15-oxo-α-cadinol ( 13 ), 1-patchoulene-4α,7α-diol ( 14 ), 10β,15-hydroxy-α-cadinol ( 15 ), cosmosoic acid ( 16 ), 4(15)-eudesmene-1β,7,11-triol ( 17 ), 3-eudesmene-1β,7,11-triol ( 18 ), 4α,7β,11-trihydroxy-1β H ,5α H -guai-10(14)-ene ( 19 ), grasshopper ketone ( 20 ), 11-oxo-13-nor-alismol ( 21 ), ( S )-3-hydroxy-β-ionone ( 22 ), (3 R ,6 R ,7 E )-3-hydroxy-4,7-megastigmadien-9-one ( 23 ), 3-hydroxy-β-ionone ( 24 ), 9-hydroxy-4-megastigmen-3-one ( 25 ), alismorientol B ( 26 ), and 4α,10α,11-trihydroxy-1β H ,5β H -guai-7(8)-ene ( 27 ), by comparison with literature data.…”

Section: Resultsmentioning

confidence: 99%

Kalshinoids A–F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae

et al. 2019

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In a study of the potential anti-inflammatory constituents from Kalimeris shimadae, six new sesquiterpenes, kalshinoids A–F (1–6), together with 21 known compounds (7–27), were isolated. The structures and absolute configurations of the new compounds were discerned from extensive spectroscopic analysis, and the absolute configurations of kalshinoids A, B, E, and F were established by ECD calculations. Furthermore, the identified compounds were tested for anti-inflammatory activity as assessed by inhibition of tumor necrosis factor-alpha (TNF-α) in THP-1 cells. Three sesquiterpenes [kalshinoid F, 4(15)-eudesmen-1β,7,11-triol, and 4α,10α,11-trihydroxy-1βH,5βH-guai-7(8)-ene] reduced levels of TNF-α in lipopolysaccharide-stimulated THP-1 cells in a concentration-dependent manner and were more potent than dexamethasone. These natural sesquiterpenes merit further investigation as possible anti-inflammatory agents.

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Section: Resultsmentioning

confidence: 99%

Kalshinoids A–F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae

et al. 2019

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Asparagus cochinchinensis

Lim¹

2014

Edible Medicinal and Non Medicinal Plants

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Rapid Detection and Characterization of Steroidal Saponins in the Root of Asparagus cochinchinensis by High-Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry

Ling

Jiang

et al. 2020

Journal of Chromatographic Science

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The dried root of Asparagus cochinchinensis (RAC) has been used as an important traditional Chinese medicine for a long time in China. Steroidal saponins (SSs) are considered to be the main active ingredients of this herb. However, the isolation and structural determination of SSs from RAC are time-consuming and laborious. For this reason, the development of new methods for the separation and characterization of SSs is highly desirable. In this study, a new high-performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF-MS/MS) method with precursor ions and the corresponding fragment ions was developed for the identification of SSs in RAC. Finally, 30 SSs have been detected and identified, including 17 potential new compounds. This is the first systematic study of SSs in RAC by HPLC-ESI-QTOF-MS/MS method.

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Two new furostanol glycosides from Asparagus cochinchinensis (Lour.) Merr.

Cited by 4 publications

References 0 publications

Kalshinoids A–F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae

Kalshinoids A–F, Anti-inflammatory Sesquiterpenes from Kalimeris shimadae

Asparagus cochinchinensis

Rapid Detection and Characterization of Steroidal Saponins in the Root of Asparagus cochinchinensis by High-Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry

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