Two new flavonol glycosides from Gymnema sylvestre and Euphorbia ebracteolata

Liu, Xin; Ye, Wen‐Cai; Yu, Bo; Zhao, Shou‐Xun; Wu, Hou‐Ming; Che, Chun‐Tao

doi:10.1016/j.carres.2003.12.017

Cited by 61 publications

(29 citation statements)

References 12 publications

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“…Triterpenoid saponins (gymnemagenin, gymnemic acids I-XIV, gymnemasins A-D), flavonoid triglycosides (Liu et al, 2004;Mukhopadhyay & Field, 2006;Peng, Zhu, Wang, & Ding, 2005;Sahu et al, 1996) H. indicus (L.) Ait. High level of chlorogenic acid and low level of di-caffeoylquinic acids, flavonol glucosides (rutin, quercetin 3-sophoroside, kaempferol 3-rutinoside), other phenolic acids (benzoic acids) and terpenoids…”

Section: Natural Product Research 213mentioning

confidence: 99%

Antioxidant properties and principal phenolic phytochemicals of Indian medicinal plants from Asclepiadoideae and Periplocoideae

Surveswaran

Cai

Xing

et al. 2010

Natural Product Research

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The subfamily Asclepiadoideae (Apocynaceae) and the closely-related Periplocoideae are sources of many indigenous Indian medicinal plants. We surveyed antioxidant properties and total phenolic and flavonoid contents of 15 samples, representing 12 Indian medicinal plant species from these subfamilies. Total antioxidant assay was performed using the 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid and ferric-reducing antioxidant power methods. Total phenolic and flavonoid contents were measured using colourimetric methods. Principal phenolic compounds were detected by liquid chromatography-mass spectrometry (LC-MS). The highest antioxidant capacity and high levels of total phenolics and flavonoids were found in the leaves of Decalepis hamiltonii. The stems of Sarcostemma brevistigma exhibited the highest xanthine oxidase (XO) inhibitory activity. The roots of Hemidesmus indicus showed the highest OH(-) radical scavenging activity. In general, Periplocoideae members exhibited higher antioxidant activity than Asclepiadoideae members. The highly significant and positive correlations (R > 0.914) between total antioxidant capacity parameters and total phenolic content indicated that the phenolic compounds contributed significantly to the antioxidant activity of the tested plant samples. The principal phenolic phytochemicals from these plants were identified by LC-MS, including flavonoids, phenolic acids and phenolic terpenoids. Chlorogenic acid and rutin were detected in almost all of the plant samples. The LC-MS analysis provided full fingerprints of the principal phenolic compounds in the medicinal plants from these two subfamilies, which are useful for their authentication and quality evaluation.

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Section: Natural Product Research 213mentioning

confidence: 99%

Antioxidant properties and principal phenolic phytochemicals of Indian medicinal plants from Asclepiadoideae and Periplocoideae

Surveswaran

Cai

Xing

et al. 2010

Natural Product Research

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“…Pharmacological studies showed that G. sylvestre has hypoglycemic [4,5], anti-caries [6,7] and weight reducing [8,9,10] effects. Triterpenoids [11,12,13,14,15,16,17,18], cyclitols [19], flavonoids [20], peptides [21], pectin [22] and alkaloids [23,24] have been isolated from this plant. Some triterpene saponins from G. sylvestre were found to be able to attenuate hyperglycemia induced by pituitary growth hormone or adrenocorticotropic hormone [25,26] and to inhibit intestinal glucose absorption in diabetic rats [27,28,29,30].…”

Section: Introductionmentioning

confidence: 99%

New Pregnane Glycosides from Gymnema sylvestre

Yang

Zhang

et al. 2015

Molecules

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Abstract:Four new pregnane glycosides 1-4 were isolated from the ethanol extract of the stem of Gymnema sylvestre and named gymsylvestrosides A-D. Hydrolysis of compound 1 under the catalysis of Aspergilus niger β-glucosidase afforded compound 5 (gymsylvestroside E). Their structures were determined by spectroscopic methods such as HRESIMS, 1D and 2D NMR, as well as HMQC-TOCSY experiment. Compounds 1-4 were screened for Saccharomyces cerevisiae α-glucosidase inhibitory activity.

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“…Therefore, the inhibition of SULT1A3 by gymnema extract is attributable not to gymnemic acid, but to other constituents, possibly flavonoids, which are abundant in gymnema. 19) St. John's wort extract also inhibited SULT1A3 at the concentration of 100 mg/ml, while its putative pharmacologically active constituent, hyperforin, did not show any inhibitory effect at concentration of up to 10 mg/ml. If the St. John's wort extract used in the study contained 2-3 mg/ml hyperforin (St. John's wort extract commonly contains 1.3-4.0% hyperforin 20) ), then hyperforin is not responsible for the inhibitory effects of St. John's wort.…”

Section: Discussionmentioning

confidence: 84%

Inhibitory Effects of Herbal Extracts on the Activity of Human Sulfotransferase Isoform Sulfotransferase 1A3 (SULT1A3)

Nagai

Fukamachi

Tsujimoto

et al. 2009

Biological & Pharmaceutical Bulletin

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Cytosolic sulfotransferases (SULTs) are a family of enzymes involved in the phase 2 detoxification of xenobiotics, including medicinal drugs such as ritodrine, salbutamol, minoxidil and paracetamol, 1,2) as well as in the sulfation of endogenous chemicals.3) Thus, inhibition of SULT activity may affect drug pharmacokinetics which in turn could cause adverse reactions.SULT1A3 and SULT1A1 are predominantly expressed in the intestinal epithelium and liver, respectively. 4) Therefore, food constituents that inhibit SULT1A3 may affect the absorption of drugs that undergo extensive presystemic sulfation, such as oral b 2 stimulants. We have previously encountered a case of adverse reaction associated with concomitant ingestion of grapefruit with the b 2 stimulant ritodrine, and demonstrated that several grapefruit constituents potently inhibit SULT1A3 and SULT1A1. 1,5) The intestinal and hepatic availabilities of ritodrine are estimated to be 0.68 and 0.54, 5) respectively, suggesting that one-third of orally administered ritodrine is considered to be eliminated by intestinal first pass and another one-third by the liver. As b 2 stimulants including ritodrine are predominantly conjugated with sulfate in humans, 6) SULTs are likely to play a key role in regulating the bioavailability of b 2 stimulants. Therefore, to avoid the above-mentioned interactions, it would be necessary to identify which foods inhibit SULT1A3 activity. However, there is little information about SULT1A3-mediated food-drug interactions, compared with the extensive studies of interactions mediated by other enzymes, such as cytochrome P450 (CYP) 3A4. 7,8) Flavonoids potently inhibit SULT1A3. 5,9,10) For example, we have reported that 10 mM quercetin and 100 mM catechin inhibit SULT1A3 activity by 50% and 70%, respectively. 5)The intestinal SULT1A3 may be potently inhibited by the ingestion of foods containing the above compounds at high Pharmacy and Life Science; 1432-1 Horinouchi, Hachiouji, Tokyo 192-0392, Japan. Received June 16, 2008 accepted October 20, 2008; published online October 23, 2008 Sulfotransferase 1A3 (SULT1A3) is a phase II detoxifying enzyme of xenobiotics predominantly expressed in the intestinal epithelium. Recent increase in the use of herbal extracts as dietary supplements may lead to an increase in the possibility of dietary supplement-drug interactions. The purpose of the present study was to investigate the effects of 18 herbal extracts on SULT1A3 activity and the possibility of interaction between medicinal drugs and herbal extracts. We examined the inhibitory potencies of 18 herbal extracts on the sulfation of dopamine, a typical substrate of SULT1A3, and ritodrine, a b b 2 stimulant, by human recombinant SULT1A3. The sulfation of dopamine was inhibited by extracts of banaba, green tea, Rafuma, grape seed, peanut seed coat, gingko biloba leaf, St. John's wort, gymnema and milkthistle. The IC 50 values of these herbal extracts were lower than the putative gastrointestinal concentration when the recommended dose was i...

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Two new flavonol glycosides from Gymnema sylvestre and Euphorbia ebracteolata

Cited by 61 publications

References 12 publications

Antioxidant properties and principal phenolic phytochemicals of Indian medicinal plants from Asclepiadoideae and Periplocoideae

Antioxidant properties and principal phenolic phytochemicals of Indian medicinal plants from Asclepiadoideae and Periplocoideae

New Pregnane Glycosides from Gymnema sylvestre

Inhibitory Effects of Herbal Extracts on the Activity of Human Sulfotransferase Isoform Sulfotransferase 1A3 (SULT1A3)

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