Two New Compounds from the Galls of <i>Quercus infectoria</i>. with Nitric Oxide and Superoxide Inhibiting Ability

Hamid, Hinna; Kaur, Gurpreet; Abdullah, Sumaiyah; Ali, Mohammed; Athar, Mohammad; Alam, Mohammad Sarwar

doi:10.1080/13880200590951711

Cited by 25 publications

(19 citation statements)

References 14 publications

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“…Water-methanolic extract of Quercus galls has a large amount of tannins. Regarding the role of microbes and the oxidative inflammatory process in induction of colitis, the first thing that comes to mind is to relate the benefit of Quercus to its antibacterial [ 29 – 34 ], antioxidant [ 35 , 36 ], and anti-inflammatory properties [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Quercus brantii galls (locally called ‘mazoo’) are famous in traditional Iranian medicine for treating chronic diarrhea and many diseases, with or without inflammatory pathogenesis [ 26 ]. Regarding its great medicinal value, Quercus galls have been reported to have the following pharmacological actions: astringent, anti-pyretic, anti-parkinsonism [ 25 ], anti-tremorine, local anesthetic, central nervous system (CNS) depressant, analgesic [ 25 , 27 ], anti-diabetic [ 25 , 28 ], anti-bacterial [ 29 – 34 ], anti-oxidant [ 35 , 36 ] and anti-inflammatory [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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On the benefit of galls of Quercus brantii Lindl. in murine colitis: the role of free gallic acid

Khanavi¹,

Sabbagh-Bani-Azad²,

Abdolghaffari³

et al. 2014

aoms

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IntroductionIn this study we investigated the effect of gall of Quercus brantii Lindl., a traditional Iranian medicine, in a murine model of experimental colitis induced in male rats by rectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS).Material and methodsQuantification of the main active components was done for estimation of total phenolic content and free gallic acid. Gall of Quercus brantii Lindl. in two forms (gall powder and gall hydro alcoholic extract) was gavaged for 10 days (500 mg/kg). Ten days after induction of colitis, colonic status was examined by macroscopic, microscopic and biochemical analyses. Colonic tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were analyzed as biomarkers of inflammatory condition. To determine the role of oxidative stress (OS) in colitis, the levels of cellular lipid peroxidation (LPO), total antioxidant power (TAP) and myeloperoxidase (MPO) were measured in colon tissues.ResultsTNBS-induced colitis exhibited a significant increase in colon MPO activity and concentrations of cellular LPO, TNF-α and IL-1β, while TAP was significantly reduced. Microscopic evaluations of the colonic damage in the colitis group revealed multifocal degenerative changes in the epithelial lining and areas of necrosis, extensive mucosal and sub-mucosal damage with congested blood vessels, edema and hemorrhages along with extensive infiltration of inflammatory cells. Parameters including macroscopic and microscopic scores, TNF-α, IL-1β, LPO, TAP and MPO improved by both gall extract and gall powder of Quercus brantii Lindl. and reached close to normal levels. The level of total phenols (GAE/100 g of sample) and free gallic acid were estimated to be 88.43 ±7.23 (mean ± SD) and 3.74% of dry weight, respectively.ConclusionsThe present study indicates that the gall of Quercus brantii Lindl. is able to exert antioxidative and anti-inflammatory effects on the biochemical and pathological parameters of colitis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

On the benefit of galls of Quercus brantii Lindl. in murine colitis: the role of free gallic acid

Khanavi¹,

Sabbagh-Bani-Azad²,

Abdolghaffari³

et al. 2014

aoms

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“…The 13 C NMR spectrum exhibited aglycone ester carbonyl carbon at δ C 170.51 (C-7), aromatic carbons at δ C 1-6 146.49, 139.69, 123.48, 110.43, 118.37, and 122.06, one anomeric sugar carbon at δ C 90.31 (C-1′) and other sugar carbons at δ C 90.31– 64.51. The methyl carbon (CH 3 ) give signals at δ C 13.18, 15.07, and 17.38 23 . The compound shows a typical fragmentation pattern with molecular ions and a few fragment ions.…”

Section: Discussionmentioning

confidence: 99%

New 4′-substituted benzoyl-β-D glycoside from the fruit pulp of Terminalia belerica with antiplatelet and antioxidant potency

Ansari

Arif

Hussain

et al. 2016

Integrative Medicine Research

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BackgroundThe fruit Terminalia belerica is a rich source of vitamins, acids, and nutraceuticals which have free radical scavenging activity. Thus, the ethanolic extract of fruit and its isolated compound (Tb-01) were intended to estimate antiplatelet and antioxidant activities.MethodsThe ethanolic extract was submitted to Si-gel CC and the compound was isolated. The compound Tb-01 was characterized as benzoyl-β-D-(4′→10″ geranilanoxy)-pyranosides on the basis of spectral data [ultra violet (UV), infrared (IR), 1H nuclear magnetic resonance (NMR), 13C NMR, and Mass Spectroscopy] and chemical analyses. The ethanolic extract and Tb-01 at different concentrations were in vitro screened for antiplatelet and antioxidant activity. The antiplatelet activity was carried out by using platelet rich plasma prepared by centrifugation of rabbit whole blood (containing 0.9% sodium citrate as anticoagulant) and antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl, reducing power, and nitric oxide anion scavenging activity models.ResultsThe compound Tb-01 was an amorphous brownish powder, yield 0.64% (w/w), melting point 105–110 °C, Retardation factor/Retention Value (Rf value) at 0.42 in methanol:chloroform (20:80) solvent system, UV absorption maxima at 243 nm, and molecular peak [M + H]+ at 394.15 m/z. It was observed that the ethanolic extract and Tb-01 at different concentrations showed significant antiplatelet and antioxidant activity. The antioxidant activity, like scavenging of 1,1-diphenyl-2-picrylhydrazyl radicals, nitric oxide radical, and reductive power were found to be concentration-dependent and increased when increasing amounts of sample were used.ConclusionMass spectra and 1H NMR confirmed the isolated compound structure which was supported by 13C NMR and IR spectra. Tb-01could be promising for future applications in the treatment of blood clots, pulmonary embolism, and other related diseases.

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“…Opposite to other dimers (like proanthocyanidin B 3 , prodelphinidin C) this compound did not exhibit any duplicate signals in its 1 H NMR spectrum. It seems that the concurrent presence of two bulky substituents at C-3 (glucose) and C-4 (catechin) forces them to assume spatial positions as far as possible, preventing rotation around the interflavanyl bond and enhancing thus one rotameric form in both methanol-d 4 and acetone-d 6 The 1 H NMR spectrum displayed signals belonging to two flavan-3-ol skeletons and a sugar moiety. Accordingly, the ESI-MS spectrum (positive ion mode) exhibited a fragment at m/z 275.0, characteristic of the presence of afzelechin, while a peak at 419.0 [M-290] suggested the loss of catechin and gave evidence of the linkage between afzelechin and a methylpentose.…”

Section: Introductionmentioning

confidence: 98%

Proanthocyanidin glycosides from the leaves of Quercus ilex L. (Fagaceae)

Karioti

Bilia

Gabbiani

et al. 2009

Tetrahedron Letters

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Two New Compounds from the Galls of Quercus infectoria. with Nitric Oxide and Superoxide Inhibiting Ability

Cited by 25 publications

References 14 publications

On the benefit of galls of Quercus brantii Lindl. in murine colitis: the role of free gallic acid

On the benefit of galls of Quercus brantii Lindl. in murine colitis: the role of free gallic acid

New 4′-substituted benzoyl-β-D glycoside from the fruit pulp of Terminalia belerica with antiplatelet and antioxidant potency

Proanthocyanidin glycosides from the leaves of Quercus ilex L. (Fagaceae)

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