Two new compounds from a marine-derived fungus<i>Penicillium</i><i>oxalicum</i>

Wang, Peile; Li, Dan-Yi; Xie, Lei-Rui; Wu, Xin; Hua, Hui‐Ming; Li, Zhan‐Lin

doi:10.1080/14786419.2013.856906

Cited by 20 publications

(12 citation statements)

References 6 publications

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“…Penicillium citrinum PSU-F51 isolated from the gorgonian sea fan Annella sp. and P. oxalicum 2-HL-M-6 (from the sea mud sample) synthesize the common chrysophanol and emodin, but also citreorosein (ω-hydroxyemodin), a compound that, to date, is only isolated from the coprophilous ascomycete Zopfiella longicaudata IFM4630 [ 88 , 91 ] . Penicillanthranins A and B (two new anthraquinone-citrinin derivatives) are also excreted by Penicillium citrinum PSU-F51.…”

Section: Anthraquinones From Marine-derived Fungimentioning

confidence: 99%

“…This strain also produces isorhodoptilometrin, which is uncommon, as it is only known from one plant-endophytic Aspergillus sp. (strain YL-6) [ 91 , 112 ]. Penicillium chrysogenum (from a saline lake in Antarctica) is the only aquatic fungus known for the production of skyrin, similarly to its terrestrial counterpart and four other terrestrial strains ( P. islandicum , Talaromyces wortmanii , and Dermocybe spp.)…”

Section: Anthraquinones From Marine-derived Fungimentioning

confidence: 99%

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Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities

et al. 2016

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Anthraquinones and their derivatives constitute a large group of quinoid compounds with about 700 molecules described. They are widespread in fungi and their chemical diversity and biological activities recently attracted attention of industries in such fields as pharmaceuticals, clothes dyeing, and food colorants. Their positive and/or negative effect(s) due to the 9,10-anthracenedione structure and its substituents are still not clearly understood and their potential roles or effects on human health are today strongly discussed among scientists. As marine microorganisms recently appeared as producers of an astonishing variety of structurally unique secondary metabolites, they may represent a promising resource for identifying new candidates for therapeutic drugs or daily additives. Within this review, we investigate the present knowledge about the anthraquinones and derivatives listed to date from marine-derived filamentous fungi′s productions. This overview highlights the molecules which have been identified in microorganisms for the first time. The structures and colors of the anthraquinoid compounds come along with the known roles of some molecules in the life of the organisms. Some specific biological activities are also described. This may help to open doors towards innovative natural substances.

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Section: Anthraquinones From Marine-derived Fungimentioning

confidence: 99%

Section: Anthraquinones From Marine-derived Fungimentioning

confidence: 99%

Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities

et al. 2016

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“…YMF 1.02105SSF of 1 kg rice5.0 mg (5.0 mg/kg)8.0 mg (8.0 mg/kg)[33] Microsphaeropsis sp. 8875SSF of 12 L agar7.0 mg (0.6 mg/L)15.0 mg (1.3 mg/L)[34] Penicillium oxalicum 2HL-M-675 L liquid fermentation11.2 mg (0.1 mg/L)14.7 mg (0.2 mg/L)[35] Zopfiella longicaudata IFM4630SSF of 20 kg rice1.5 mg (0.1 mg/kg)NA[36] Rumex aquaticus 0.55 kg dried roots3.4 mg (6.2 mg/kg)5.2 mg (9.5 mg/kg)[37] Reynoutria japonica 10 kg dried roots8.4 mg (0.8 mg/kg)467.1 mg (46.7 mg/kg)[38] Cassia nigricans 0.5 kg dried leaf32.4 mg (64.8 mg/kg)32.0 mg (64.0 mg/kg)[39] Aspergillus cristatus CB100020.15 kg HOL residues8.5 mg (56.7 mg/kg)8.3 mg (55.3 mg/kg)This study SSF solid state fermentation, NA not available…”

Section: Resultsmentioning

confidence: 99%

Recycling of Chinese herb residues by endophytic and probiotic fungus Aspergillus cristatus CB10002 for the production of medicinal valuable anthraquinones

et al. 2019

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Background The global prevalence of traditional Chinese medicine stimulates the prosperous development of herb medicines, but the annual generation of massive herb residues becomes big issues about environmental pollution and waste of resources. Microbes play important roles in the circulation of substances in nature, and endophytes represent an underexplored microbial resource possessing the unique symbiotic relationship with plants, not only for discovery of secondary metabolites, but also for potential green recycling of herb residues. Results The recycling capacities of several endophytic strains were respectively evaluated via solid state fermentation with herb residues of commercial Huazhenghuisheng oral-liquid (HOL). Among them, Aspergillus cristatus CB10002, a probiotic fungus isolated from Chinese Fu-brick tea, was competent to recycle HOL residues for the production of medicinal valuable anthraquinones, in which four of them, especially citreorosein with significant anti-obesity activity, were first discovered in A. cristatus . Subsequent quantitative analysis showed that about 2.0 mg/g citreorosein and 7.5 mg/g total anthraquinones could be obtained after 35-day fermentation, which was very competitive and economically beneficial. Further nutritional comparisons also revealed that the recycling process indeed ameliorated the nutrients of HOL residues, and thus proposed a possibility to directly dispose the final leftovers as a compost organic fertilizer. Conclusions The endophytic and probiotic fungus A. cristatus CB10002 isolated from Chinese Fu-brick tea was screened out to effectively reutilize HOL residues for the production of nine medicinal valuable anthraquinones, whose biosynthesis may be regulated by the induction of HOL residues. The competitive yields of these anthraquinones, as well as the certain composting properties of final leftovers, have made the microbial recycling of HOL residues economically beneficial. Our work demonstrated a promising applied potential of A. cristatus in reutilization of herb residues, and provided a practical strategy for sustainable and value-added microbial recycling of herb residues. Electronic supplementary material The online version of this article (10.1186/s12934-019-1150-9) contains supplementary material, which is available to authorized users.

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“…[ 36 , 37 ], Penicillium sp. [ 38 , 39 , 40 , 41 , 42 , 43 ], Talaromyces sp. [ 44 , 45 ] or Cordyceps unilateralis [ 46 ], Curvularia lunata, Herpotrichia rhodosticta [ 47 ] were described to produce pigments by fermentative technology.…”

Section: Introductionmentioning

confidence: 99%

OVAT Analysis and Response Surface Methodology Based on Nutrient Sources for Optimization of Pigment Production in the Marine-Derived Fungus Talaromyces albobiverticillius 30548 Submerged Fermentation

et al. 2021

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Pigment production from filamentous fungi is gaining interest due to the diversity of fungal species, the variety of compounds synthesized, and the possibility of controlled massive productions. The Talaromyces species produce a large panel of metabolites, including Monascus-like azaphilone pigments, with potential use as natural colorants in industrial applications. Optimizing pigment production from fungal strains grown on different carbon and nitrogen sources, using statistical methods, is widespread nowadays. The present work is the first in an attempt to optimize pigments production in a culture of the marine-derived T. albobiverticillius 30548, under the influence of several nutrients sources. Nutrient combinations were screened through the one-variable-at-a-time (OVAT) analysis. Sucrose combined with yeast extract provided a maximum yield of orange pigments (OPY) and red pigments (RPY) (respectively, 1.39 g/L quinizarin equivalent and 2.44 g/L Red Yeast pigment equivalent), as well as higher dry biomass (DBW) (6.60 g/L). Significant medium components (yeast extract, K2HPO4 and MgSO4·7H2O) were also identified from one-variable-at-a-time (OVAT) analysis for pigment and biomass production. A five-level central composite design (CCD) and a response surface methodology (RSM) were applied to evaluate the optimal concentrations and interactive effects between selected nutrients. The experimental results were well fitted with the chosen statistical model. The predicted maximum response for OPY (1.43 g/L), RPY (2.59 g/L), and DBW (15.98 g/L) were obtained at 3 g/L yeast extract, 1 g/L K2HPO4, and 0.2 g/L MgSO4·7H2O. Such optimization is of great significance for the selection of key nutrients and their concentrations in order to increase the pigment production at a pilot or industrial scale.

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Two new compounds from a marine-derived fungusPenicilliumoxalicum

Abstract: Two new anthraquinones, emodin-3-O-sulphate (1) and citreorosein-3-O-sulphate (2), as well as five known anthraquinones, were isolated from a marine-derived fungus Penicillium oxalicum. The structures of these compounds were determined by spectroscopic methods (1D and 2D NMR, HR-ESI-MS).

Cited by 20 publications

References 6 publications

Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities

Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities

Recycling of Chinese herb residues by endophytic and probiotic fungus Aspergillus cristatus CB10002 for the production of medicinal valuable anthraquinones

OVAT Analysis and Response Surface Methodology Based on Nutrient Sources for Optimization of Pigment Production in the Marine-Derived Fungus Talaromyces albobiverticillius 30548 Submerged Fermentation

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