Two New Bioactive Biphenylpropanoids from the Roots of Salsola imbricata (Chenopodiaceae) Growing in Saudi Arabia

Oueslati, Mohamed Habib; Bouajila, Jalloul; Jannet, Hichem Ben

doi:10.13005/ojc/330432

Cited by 7 publications

(18 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ethyl acetate soluble fraction of the alcoholic extract from their roots afforded an alkaloidal phenolic, N - trans -feruloyltyramine ( 103 ), in addition to isovanillic acid ( 83 ), ferulic acid ( 90 ) and p -hydroxy benzoic acid ( 71 ) [ 71 ]. Moreover, Bi-phenylpropanoids, named biphenylsalsonoid A ( 62 ) and biphenylsalsonoid B ( 61 ), were also isolated [ 72 ].…”

Section: Chemistry Of Salsolamentioning

confidence: 99%

“…The two compounds had a similar effectiveness against the tested bacteria, with MIC values ranging from 16 to 64 µg/mL. On the other hand, biphenylsalsonoid B ( 61 ) showed higher potency than biphenylsalsonoid A ( 62 ) against M. luteus [ 72 ].…”

Section: Overview Of the Benefits Uses And Medicinal Properties Of ...mentioning

confidence: 99%

“…Biphenylsalsonoid A ( 62 ) and B ( 61 ), which was isolated from the roots of S. imbricata , showed a moderate activity towards DPPH, with IC 50 values of 86.5 ±1.3 and 122.3 ± 1.4 µg/mL, respectively, and ABTS with IC 50 values of 95.1 ± 1.5 and 137.7 ± 1.2 µg/mL, respectively. Biphenylsalsonoid A ( 62 ) had a relatively higher activity due to the presence of two phenol groups [ 72 ]. Quercitrin ( 5 ) and rosmarinic acid ( 87 ), both isolated from S. imbricata , have been shown to protect against CCl 4 -induced hepatotoxicity and have a high anti-oxidant potential [ 110 ].…”

Section: Overview Of the Benefits Uses And Medicinal Properties Of ...mentioning

confidence: 99%

See 2 more Smart Citations

Genus Salsola: Chemistry, Biological Activities and Future Prospective—A Review

Murshid

Atoum

Abou-Hussein

et al. 2022

Plants

View full text Add to dashboard Cite

The genus Salsola L. (Russian thistle, Saltwort) includes halophyte plants and is considered one of the largest genera in the family Amaranthaceae. The genus involves annual semi-dwarf to dwarf shrubs and woody tree. The genus Salsola is frequently overlooked, and few people are aware of its significance. The majority of studies focus on pollen morphology and species identification. Salsola has had little research on its phytochemical makeup or biological effects. Therefore, we present this review to cover all aspects of genus Salsola, including taxonomy, distribution, differences in the chemical constituents and representative examples of isolated compounds produced by various species of genus Salsola and in relation to their several reported biological activities for use in folk medicine worldwide.

show abstract

Section: Chemistry Of Salsolamentioning

confidence: 99%

Section: Overview Of the Benefits Uses And Medicinal Properties Of ...mentioning

confidence: 99%

Section: Overview Of the Benefits Uses And Medicinal Properties Of ...mentioning

confidence: 99%

See 1 more Smart Citation

Genus Salsola: Chemistry, Biological Activities and Future Prospective—A Review

Murshid

Atoum

Abou-Hussein

et al. 2022

Plants

View full text Add to dashboard Cite

show abstract

“…In a recent study from Saudi Arabia, phytochemical analysis of S. imbricata showed presence of bioactive biphenylpropanoids i.e., biphenylsalsonoid A and B. These two bioactive compounds exhibited antioxidant and antibacterial activity against human pathogenic bacteria (Oueslati et al, 2017 ). Although the coastal dune environment is an unexplored source of natural compounds with diverse activities there has been little or no work on the bacterial flora of this plant.…”

Section: Introductionmentioning

confidence: 99%

Microbial Flora Associated with the Halophyte–Salsola imbricate and Its Biotechnical Potential

et al. 2018

View full text Add to dashboard Cite

Halophytes are associated with the intertidal forest ecosystem of Saudi Arabia and seemingly have an immense potential for yielding useful and important natural products. In this study we have aimed to isolate and characterize the endophytic and rhizospheric bacterial communities from the halophyte, Salsola imbricata, In addition these bacterial strains were identified and selected strains were further studied for bioactive secondary metabolites. At least 168 rhizspheric and endophytic bacteria were isolated and of these 22 were active antagonists against the oomycetous fungal plant pathogens, Phytophthora capsici and Pythium ultimum. Active cultures were mainly identified with molecular techniques (16S r DNA) and this revealed 95.7–100% sequence similarities with relevant type strains. These microorgansims were grouped into four major classes: Actinobacteria, Firmicutes, β-Proteobacteria, and γ-Proteobacteria. Production of fungal cell wall lytic enzymes was detected mostly in members of Actinobacteria and Firmicutes. PCR screening for type I polyketide synthases (PKS-I), type II polyketide synthases (PKS-II) and nonribosomal peptide synthetases (NRPS) revealed 13 of the 22 strains (59%) were positive for at least one of these important biosynthetic genes that are known to be involved in the synthesis of important antibiotics. Four bacterial strains of Actinobacteria with potential antagonistic activity including two rhizobacteria, EA52 (Nocardiopsis sp.), EA58 (Pseudonocardia sp.) and two endophytic bacteria Streptomyces sp. (EA65) and Streptomyces sp. (EA67) were selected for secondary metabolite analyses using LC-MS. As a result, the presence of different bioactive compounds in the culture extracts was detected some of which are already reported for their diverse biological activities including antibiotics such as Sulfamethoxypyridazine, Sulfamerazine, and Dimetridazole. In conclusion, this study provides an insight into antagonistic bacterial population especially the Actinobacteria from S. imbricata, producing antifungal metabolites of medical significance and characterized taxonomically in future.

show abstract

“…Apart from these, there are no other reports concerning the chemical and pharmacological investigations of S. cyclophylla growing in Saudi Arabia. However, several phytoconstituents are reported from other Salsola species, e.g., flavonoids, phenolic acids [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ], sterols, hydroxy-fatty acids [ 19 ], alkaloids, organic acids [ 20 ], phenylpropanoids [ 21 ], and triterpenoidal saponins [ 22 ]. Among the bioactivities, the anti-oxidant and anti-microbial [ 12 , 13 , 19 ], anti-inflammatory [ 14 ], contraceptive [ 15 ], anti-nociceptive [ 17 ], and anti-diabetic [ 18 ] activities are reported for the plants extracts, fractions, and isolated compounds.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis, Pharmacological and Safety Evaluations of Halophytic Plant, Salsola cyclophylla

et al. 2021

View full text Add to dashboard Cite

Salsola cyclophylla, an edible halophyte, is traditionally used for inflammation and pain. To confirm the claimed anti-inflammatory and analgesic properties, a detailed study on respective pharmacological actions was undertaken. The activities are contemplated to arise from its phytoconstituents. The LC-MS analysis of S. cyclophylla 95% aqueous-ethanolic extract revealed the presence of 52 compounds belonging to phenols, flavonoids, coumarins, and aliphatics class. A high concentration of Mn, Fe, and Zn was detected by atomic absorption spectroscopic analysis. The ethyl acetate extract showed the highest flavonoid contents (5.94 ± 0.04 mg/g, Quercetin Equivalents) and Fe2+-chelation (52%) potential with DPPH radicals-quenching IC50 at 1.35 ± 0.16 mg/mL, while the aqueous ethanolic extract exhibited maximum phenolics contents (136.08 ± 0.12 mg/g, gallic acid equivalents) with DPPH scavenging potential at IC50 0.615 ± 0.06 mg/mL. Aqueous ethanolic extract and standard quercetin DPPH radicals scavenging’s were equal potent at 10 mg/mL concentrations. The aqueous ethanolic extract showed highest analgesic effect with pain reduction rates 89.86% (p = 0.03), 87.50% (p < 0.01), and 99.66% (p = 0.0004) after 60, 90, and 120 min, respectively. Additionally, aqueous ethanolic extract exhibited the highest anti-inflammation capacity at 41.07% (p < 0.0001), 34.51% (p < 0.0001), and 24.82% (p < 0.0001) after 2, 3, and 6 h of extract’s administration, respectively. The phytochemical constituents, significant anti-oxidant potential, remarkable analgesic, and anti-inflammatory bioactivities of extracts supported the traditionally claimed anti-inflammatory and analgesic plant activities.

show abstract

Two New Bioactive Biphenylpropanoids from the Roots of Salsola imbricata (Chenopodiaceae) Growing in Saudi Arabia

Cited by 7 publications

References 10 publications

Genus Salsola: Chemistry, Biological Activities and Future Prospective—A Review

Genus Salsola: Chemistry, Biological Activities and Future Prospective—A Review

Microbial Flora Associated with the Halophyte–Salsola imbricate and Its Biotechnical Potential

Phytochemical Analysis, Pharmacological and Safety Evaluations of Halophytic Plant, Salsola cyclophylla

Contact Info

Product

Resources

About