Two New Arylnaphthalide Lignans and Antiplatelet Constituents from Justicia procumbens

Weng, Jing‐Ru; Ko, Horng‐Huey; Yeh, Ting-Li; Lin, Hsien-Cheng; Lin, Chun‐Nan

doi:10.1002/chin.200434236

Cited by 9 publications

(20 citation statements)

References 1 publication

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“…Given its extensive medicinal use, research into its chemical composition has been ongoing since the early 1970s. As a result of this work, researchers from Japan and Taiwan determined that the main constituents in J. procumbens are lignans and glycosides . In addition, the majority of natural arylnaphthalenes in J. procumbens are lactones, which represent a significant subclass of lignans (e.g., 1‐aryl naphthalide and 4‐aryl naphthalide) .…”

Section: Introductionmentioning

confidence: 94%

Ultra high performance liquid chromatography–electrospray ionization‐tandem mass spectrometry and pharmacokinetic analysis of justicidin B and 6′‐hydroxy justicidin C in rats

Luo

Qin

et al. 2016

J of Separation Science

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Arylnaphthalene lignans have attracted considerable interest with the discovery of their antineoplastic activities. Two such compounds are justicidin B and 6'-hydroxy justicidin C, both of which have been isolated from the herb Justicia procumbens. We sought to develop and validate a sensitive and accurate, ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry method for the structural determination and pharmacokinetics of justicidin B and 6'-hydroxy justicidin C. Chromatographic separation was achieved on an Agilent 300SB-C column using water (0.5% formic acid, 10 mM NH COOH) methanol as the mobile phase. The plasma samples obtained after oral administration of the active extract of Justicia procumbens were successfully analyzed with our novel method, thereby demonstrating its sound applicability and reliability. The lower limit of quantification for justicidin B and 6'-hydroxy justicidin C was 0.50 and 1.00 ng/mL in 50 μL rat plasma, respectively. The elimination half-life and clearance of justicidin B was estimated to be 1.27 ± 0.61 h and 5.40 ± 0.22 L/h/kg while that of 6'-hydroxy justicidin C was 2.07 ± 0.70 h and 11.84 ± 1.06 L/h/kg. This newly developed and validated method was successfully applied to the quantification and pharmacokinetic study of justicidin B and 6'-hydroxy justicidin C in rats.

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Section: Introductionmentioning

confidence: 94%

Ultra high performance liquid chromatography–electrospray ionization‐tandem mass spectrometry and pharmacokinetic analysis of justicidin B and 6′‐hydroxy justicidin C in rats

Luo

Qin

et al. 2016

J of Separation Science

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“…5). [32][33][34][35][36] Within the neolignans, three subgroups are distinguished: the oxyneolignans, the sesquineolignans and the dineolignans. The oxyneolignans have their C-9 units linked via an ether bond.…”

Section: Lignans and Neolignansmentioning

confidence: 99%

“…They exhibit anti‐platelet, antiviral, anti‐tumour, anti‐depressant and pesticidal activities (Fig. ) …”

Section: Introductionmentioning

confidence: 99%

A critique on the structural analysis of lignins and application of novel tandem mass spectrometric strategies to determine lignin sequencing

et al. 2015

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This review is devoted to the application of MS using soft ionization methods with a special emphasis on electrospray ionization, atmospheric pressure photoionization and matrix-assisted laser desorption/ionization MS and tandem MS (MS/MS) for the elucidation of the chemical structure of native and modified lignins. We describe and critically evaluate how these soft ionization methods have contributed to the present-day knowledge of the structure of lignins. Herein, we will introduce new nomenclature concerning the chemical state of lignins, namely, virgin released lignins (VRLs) and processed modified lignins (PML). VRLs are obtained by liberation of lignins through degradation of vegetable matter by either chemical hydrolysis and/or enzymatic hydrolysis. PMLs are produced by subjecting the VRL to a series of further chemical transformations and purifications that are likely to alter their original chemical structures. We are proposing that native lignin polymers, present in the lignocellulosic biomass, are not made of macromolecules linked to cellulose fibres as has been frequently reported. Instead, we propose that the lignins are composed of vast series of linear related oligomers, having different lengths that are covalently linked in a criss-cross pattern to cellulose and hemicellulose fibres forming the network of vegetal matter. Consequently, structural elucidation of VRLs, which presumably have not been purified and processed by any other type of additional chemical treatment and purification, may reflect the structure of the native lignin. In this review, we present an introduction to a MS/MS top-down concept of lignin sequencing and how this technique may be used to address the challenge of characterizing the structure of VRLs. Finally, we offer the case that although lignins have been reported to have very high or high molecular weights, they might not exist on the basis that such polymers have never been identified by the mild ionizing techniques used in modern MS.

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“…[10][11] Among the chemical compounds from the plant are reported: lignans and their glycosides, alkaloids, tannins, diterpenoids, cyanogenitic compounds and saponins. [12][13] The purpose of this study was to evaluate the antimicrobial potency of aqueous extract of Kodakasalai Chooranam (Justicia procumbens) by diffusion method in agar medium.…”

Section: Introductionmentioning

confidence: 99%

Screening of Antibacterial and Antifungal Activities of Siddha Herbal Drug Kodagasalai Chooranam (Justicia Procumbens)

Vinothkumar¹

2017

WJPR

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This present study aims to validate the antimicrobial activity of Siddha World Journal of Pharmaceutical ResearchEthanol and chloroform extracts showed moderate activity against gram positive bacteria.The antibacterial activity was more apparent in ethanol extract as compared to chloroform extract for all tested organisms. The aqueous and ethanol extracts showed no activity against the yeast Candida albicans. But Chloroform extract showed marked inhibitory effect against Candida albicans. It can be concluded that the results of this study support traditional use ofJusticia procumbens for its antimicrobial activity in Siddha system of medicine.

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Two New Arylnaphthalide Lignans and Antiplatelet Constituents from Justicia procumbens

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 9 publications

References 1 publication

Ultra high performance liquid chromatography–electrospray ionization‐tandem mass spectrometry and pharmacokinetic analysis of justicidin B and 6′‐hydroxy justicidin C in rats

Ultra high performance liquid chromatography–electrospray ionization‐tandem mass spectrometry and pharmacokinetic analysis of justicidin B and 6′‐hydroxy justicidin C in rats

A critique on the structural analysis of lignins and application of novel tandem mass spectrometric strategies to determine lignin sequencing

Screening of Antibacterial and Antifungal Activities of Siddha Herbal Drug Kodagasalai Chooranam (Justicia Procumbens)

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