Two neolignans from Perilla frutescens and Their inhibition of nitric oxide synthase and tumor necrosis factor-α expression in murine macrophage cell line RAW 264.7

Synthesis of cyclobutane lignans via an organic single electron oxidant–electron relay system

“…2 Many of these cyclobutane lignans and neolignans have significant bioactivity and are often considered as lead compounds for the development of antifungal, antiviral, and anticancer drugs. 3 Several cyclobutane lignan natural products have notable inhibitory activity toward nitric oxide synthase (NOS) enzymes, 4 as well as potent binding to the glucocorticoid receptor (GR). 5 Despite the biological importance of this class of compounds, there have been few efforts devoted to the stereoselective synthesis of cyclobutane lignans and potentially valuable analogs.…”

Luteolin Inhibits LPS-Stimulated Inducible Nitric Oxide Synthase Expression in BV-2 Microglial Cells

“…Perilla frutescens has been used in traditional Chinese medicine, where it is used to dispel cold, to regulate stomach function, to induce perspiration, to relax the bowels and to alleviate pain. The extracts of Perilla frutescens were reported to modulate the production of NO [14] and TNF-a [15], and the active compounds were elucidated as magnosalin and andamanicin [16]. The antiinflammatory activity of luteolin was evaluated in in vivo and in vitro systems showing inhibition of serum TNF-a production [17], and inhibition of pro-inflammatory cytokines due to the selective elimination of monocytes in peripheral blood mononuclear cells [18].…”

Quercetin Derivatives from Siegesbeckia glabrescens Inhibit the Expression of COX-2 Through the Suppression of NF-κB Activation in Microglia

“…As a part of our on-going screening program to evaluate the anti-infl ammatory potentials of plant-derived compounds (Ryu et al, 2002;Lee et al, 2005;Yoon et al, 2008), we investigated the inhibitors of PGE 2 synthesis in LPS-activated microglia. Siegesbeckia glabrescens (Compositae), well known as 'Hi-Chum' has been used as traditional medicine for the treatment of rheumatoid arthritis, asthma, paralysis and allergic disorders.…”

“…We have reported sesquiterpenes (Yoon et al, 2008), lignans (Ryu et al, 2002) and fl avonoids (Lee et al, 2005) that can inhibit the expression of iNOS and COX-2 in activated microglia. Here, we report the identifi cation of four quercetin derivatives from Siegesbeckia glabrescens and their inhibitory activities of PGE 2 production, COX-2 expression and NF-κB activation.…”