Two natural glucomannan polymers, from Konjac and Bletilla, as bioactive materials for pharmaceutical applications

Wang, Yu; Liu, Jingjing; Li, Qiu; Wang, Ying; Wang, Chunming

doi:10.1007/s10529-014-1647-6

Cited by 101 publications

(45 citation statements)

References 50 publications

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“…B. striata polysaccharide (BSP) is extracted from B. striata and consists of α-mannose, β-mannose and β-glucose (17). BSP has a number of biological functions, including anti-inflammatory (18), anti-tumor (19), anti-fibrosis (20) and antibacterial (21) properties, as well as inducing endothelial cell proliferation and vascular endothelial growth-factor expression (16).…”

Section: Introductionmentioning

confidence: 99%

Bletilla�striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats

et al. 2018

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It has been reported that intestinal epithelial barrier dysfunction serves an important role in the development of liver cirrhosis. However, at present there is no satisfactory treatment for intestinal mucosal lesions and ulcers associated with cirrhosis. The aim of the present study was to investigate the effect of Bletilla striata polysaccharide (BSP) on intestinal epithelial barrier disruption in rats with thioacetamide (TAA)-induced liver cirrhosis. Rats were randomly divided into 5 groups (n=10): BSP low dosage (15 mg/kg), BSP middle dosage (30 mg/kg), BSP high dosage (60 mg/kg), experiment and control groups. All groups except control group were administered with TAA (200 mg/kg/day) to induce liver cirrhosis. Following modeling, rats in the low, middle and high-dose BSP groups received BSP. ELISA kits were used to measure the endotoxin, alanine transaminase (ALT) and aspartate transaminase (AST) levels in the portal vein, while interleukin (IL)-6 and tumor necrosis factor (TNF)-α expression in the ileal tissue was measured. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting were used to detect the expression of zonula occludens (ZO)-1 and occludin mRNA and protein, respectively. Intestinal epithelial tissue pathology was detected using hematoxylin-eosin (HE) staining. Immunohistochemistry was performed to assess the expression of ZO-1 and occludin in intestinal epithelial tissues. Following treatment with BSP, ALT, AST and endotoxin levels in the portal vein, as well as IL-6 and TNF-α expression in ileal tissues, were significantly decreased compared with model group (P<0.05 or 0.01). Furthermore, BSP treatment upregulated the expression of ZO-1 and occludin mRNA and protein compared with the model group (P<0.05 or 0.01) and cytoplasmic staining for these proteins was increased. The degree of intestinal epithelial tissue pathological damage was significantly reduced in the BSP groups. In conclusion, BSP is able to reduce endotoxin levels, inhibit the inflammatory cytokines IL-6 and TNF-α and elevate expression of ZO-1 and occludin at tight junctions. Together, these results suggest a novel protective agent for the restoration of intestinal epithelial barrier disruption.

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Section: Introductionmentioning

confidence: 99%

Bletilla�striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats

et al. 2018

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“…Compared to other groups, the special surface structures of BSMPs (350–250 μ m) enable them to promote blood/particle aggregation and to form rapid sealants on wound surfaces to achieve rapid hemostasis. Recent studies have shown that B. striata contains numerous polysaccharides that have been identified as major active components responsible for the various biological effects [12]. Furthermore, bioactivity evaluations have revealed hemostatic activities of B. striata polysaccharides [13].…”

Section: Discussionmentioning

confidence: 99%

Bletilla striata Micron Particles Function as a Hemostatic Agent by Promoting Rapid Blood Aggregation

Zhang

Zeng

Liao

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The human body cannot control blood loss without treatment. Available hemostatic agents are ineffective at treating cases of severe bleeding and are expensive or raise safety concerns. Bletilla striata serve as an inexpensive, natural, and promising alternative. However, no detailed studies on its hemostatic approach have been performed. The aim of this study was to examine the hemostatic effects of B. striata Micron Particles (BSMPs) and their hemostatic mechanisms. We prepared and characterized BSMPs of different size ranges and investigated their use as hemostatic agent. BSMPs of different size ranges were characterized by scanning electron microscope. In vitro coagulation studies revealed BSMP-blood aggregate formation via stereoscope and texture analyzers. In vivo studies based on rat injury model illustrated the BSMP capabilities under conditions of hemostasis. Compared to other BSMPs of different size ranges, BSMPs of 350–250 μm are most efficient in hemostasis. As powder sizes decrease, the degree of aggregation between particles and hemostatic BSMP effects declines. The BSMP in contact with a bleeding surface locally forms a visible particle/blood aggregate as a physical barrier that facilitates hemostasis. Considering the facile preparation, low cost, and long shelf life of B. striata, BSMPs offer great potential as mechanisms of trauma treatment.

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“…It is especially used in Japanese food industries as low calorie food supplement. Konjac gum films can be used for controlled release of medicines [31].…”

Section: Polysaccharides and Healthmentioning

confidence: 99%

Polysaccharides in Human Health Care

Dam

Broek

Boeriu

2017

Natural Product Communications

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Polysaccharides are abundant natural polymers found in plants, animals and microorganisms with exceptional properties and essential roles to sustain life. They are well known for their high nutritive value and the positive effects on our immune and digestive functions and detoxification system. The knowledge and recognition of the important role they play for promoting and maintaining human health and wellbeing is continuously increasing. This review describes some important polysaccharides (e.g. mucilages and gums, glycosamine glycans and chitin/chitosan) and their medical, cosmetic and pharmaceutical applications, with emphasis on the relationship between structure and function. Next, the use of polysaccharides as nutraceuticals and vaccines is discussed in more detail. An analysis of the trends and challenges in polysaccharide research concludes the paper.

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Two natural glucomannan polymers, from Konjac and Bletilla, as bioactive materials for pharmaceutical applications

Cited by 101 publications

References 50 publications

Bletilla�striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats

Bletilla�striata polysaccharide has a protective effect on intestinal epithelial barrier disruption in TAA‑induced cirrhotic rats

Bletilla striata Micron Particles Function as a Hemostatic Agent by Promoting Rapid Blood Aggregation

Polysaccharides in Human Health Care

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