Two methods for direct assessment of the Vitamin D synthetic capacity of sunlight and artificial UV sources

Terenetskaya, I. P.

doi:10.1016/j.jsbmb.2004.03.043

Cited by 13 publications

(9 citation statements)

References 15 publications

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“…For example, exposure to suberythemal doses of sunshine on hands, arms and face two or three times per week is more than adequate to satisfy vitamin D requirements (Holick, 2002). Use of a more direct method of assessing sunshine exposure, such as UV dosimetry may be a more meaningful approach for assessing summer sunshine exposure as a determinant of serum 25 (OH) D levels (Terenetskaya, 2004).…”

Section: Discussionmentioning

confidence: 99%

Determinants of vitamin D status in adult Crohn's disease patients, with particular emphasis on supplemental vitamin D use

2006

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Objective: To investigate determinants (pathophysiologic and physiologic, behavioural and lifestyle) of vitamin D status in Irish Crohn's disease (CD) patients. Design: A cross-sectional observational study. Setting: Cork City, Ireland (521N). Subjects: Crohn's Disease patients (n ¼ 58; mean age 38.1 years) were recruited from Cork University Hospital. Results: Fifty and nineteen percent of Irish CD patients were vitamin D deficient (defined by serum 25 hydroxyvitamin (OH) D levels o50 nmol/l) during winter and summer, respectively. Multiple regression analysis showed that summer-time serum 25 (OH) D levels were positively associated with use of vitamin D supplements (P ¼ 0.033) and negatively associated with smoking (P ¼ 0.006) and being male (P ¼ 0.063). During winter-time, use of vitamin D supplements (P ¼ 0.041) and sun habits (P ¼ 0.066) were positively associated, whereas small intestinal involvement (P ¼ 0.005) and body mass index (BMI) (P ¼ 0.083) were negatively associated with serum 25 (OH) D levels. There was no significant association between other nonpathophysiologic (age, dietary calcium or vitamin D) or pathophysiologic factors (steroid use, resection), and serum 25 (OH) D levels, at either season. Approximately 41 and 60% of the total variation in summer-and winter-time serum 25 (OH) D, respectively, was explained by this model. Conclusion: A high proportion of Irish CD patents had some level of vitamin D deficiency (o50 nmol/l) during late-wintertime. Use of regular low-dose supplemental vitamin D, particularly by patients with small intestinal involvement, cessation of smoking and adequate, but responsible, exposure to summer sunlight as well as maintaining BMI in the normal range could help maintain adequate vitamin D levels during wintertime.

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Section: Discussionmentioning

confidence: 99%

Determinants of vitamin D status in adult Crohn's disease patients, with particular emphasis on supplemental vitamin D use

2006

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“…Despite these weaknesses, it provides important information on doses of sun exposure needed for adequate vitamin D synthesis while avoiding dangerous overexposure to the sun. Other studies (26,30) have also provided data on estimated UV exposure times required for vitamin D synthesis using in vitro systems such as spectrophotometric analysis of the previtamin D content in ethanol solutions of 7-dehydrocholesterol during UV exposure. A particular strength of the study by Webb & Engelsen (26) was that it predicted sun exposure times needed for adequate vitamin D synthesis for different skin types.…”

Section: Uv Radiation and Vitamin Dmentioning

confidence: 99%

Vitamin D in health and disease: an insight into traditional functions and new roles for the ‘sunshine vitamin’

Borradale

Kimlin

2009

Nutr. Res. Rev.

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Vitamin D is unique among the vitamins in that man can synthesise it via the action of UV radiation upon the skin. This combined with its ability to act on specific target tissues via vitamin D receptors (VDR) make its classification as a steroid hormone more appropriate. While vitamin D deficiency is a recognised problem in some northern latitude countries, recent studies have shown that even in sunny countries, such as Australia, vitamin D deficiency may be more prevalent than first thought. Vitamin D is most well known for its role in bone health; however, the discovery of VDR on a wide variety of tissue types has also opened up roles for vitamin D far beyond traditional bone health. These include possible associations with autoimmune diseases such as multiple sclerosis and inflammatory bowel diseases, cancer, CVD and muscle strength. First, this paper presents an overview of the two sources of vitamin D: exposure to UVB radiation and food sources of vitamin D, with particular focus on both Australian and international studies on dietary vitamin D intake and national fortification strategies. Second, the paper reviews recent epidemiological and experimental evidence linking vitamin D and its role in health and disease for the major conditions linked to suboptimal vitamin D, while identifying significant gaps in the research and possible future directions for research.

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“…It should be pointed out, however, that these questionnaires are crude estimates of sunshine exposure. Use of a more direct method of assessing sunshine exposure, such as ultraviolet dosimetry, may be a more meaningful approach for assessing summer sunshine exposure as a determinant of serum 25OH-D levels 52 . Vitamin D intake was not associated with wintertime serum 25OH-D levels in postmenopausal women in the present study.…”

mentioning

confidence: 99%

Vitamin D status of 51–75-year-old Irish women: its determinants and impact on biochemical indices of bone turnover

Hill

O’Brien

Lamberg‐Allardt

et al. 2006

Public Health Nutr.

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Objectives: To assess the vitamin D status of Irish postmenopausal women during wintertime, and to examine its relationship with serum parathyroid hormone (PTH) and biochemical markers of bone turnover. In addition, the determinants of wintertime serum 25-hydroxyvitamin D (25OH-D) levels in these women were investigated. Design: A cross-sectional observational study. Setting: Cork City, Ireland (528N). Subjects: Ninety-five apparently healthy, free-living postmenopausal women (aged 51 -75 years), not taking any medication and free from any condition likely to affect vitamin D status or calcium/bone metabolism. Results: Forty-eight per cent and 7% of women had serum 25OH-D levels , 50 nmol l 21 and , 25 nmol l 21, respectively. 25OH-D levels in these women were positively associated with dietary calcium intake (P ¼ 0.0002) and use of vitamin Dcontaining supplements (P ¼ 0.031), and negatively associated with cigarette smoking (P ¼ 0.027) and body mass index (BMI) (P ¼ 0.030). Low serum 25OH-D levels (, 50 nmol l 21 ) were associated (P , 0.01) with elevated serum PTH levels. There were no significant differences in urinary pyridinium crosslinks or serum osteocalcin, biochemical indices of bone turnover, between subjects with serum 25OH-D levels above or below 50 nmol l 21 . Conclusion: A high proportion of Irish postmenopausal women had low vitamin D status (, 50 nmol l 21 ) during late wintertime, which appeared to lead to elevated levels of serum PTH but not of bone turnover markers. Use of regular low-dose supplemental vitamin D, meeting daily calcium recommendations, cessation of smoking and maintaining BMI in the normal range are important factors that could help maintain adequate vitamin D levels during wintertime in these women.

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Two methods for direct assessment of the Vitamin D synthetic capacity of sunlight and artificial UV sources

Cited by 13 publications

References 15 publications

Determinants of vitamin D status in adult Crohn's disease patients, with particular emphasis on supplemental vitamin D use

Determinants of vitamin D status in adult Crohn's disease patients, with particular emphasis on supplemental vitamin D use

Vitamin D in health and disease: an insight into traditional functions and new roles for the ‘sunshine vitamin’

Vitamin D status of 51–75-year-old Irish women: its determinants and impact on biochemical indices of bone turnover

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