Two Meningiomas Detected Incidentally by Tc-99m HDP Bone Scintigraphy During a Work-Up for Breast Cancer

Gk, Lee; Coel, Marc N.; Ko, Jih‐Yang; B, Tom

doi:10.1097/00003072-199907000-00014

Cited by 10 publications

(3 citation statements)

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“…18,19 Primary meningiomas have also been reported in patients previously diagnosed with metastatic breast cancer. 20,21 Radiographic features considered characteristic of optic nerve sheath meningioma, 22 such as the ''tram track sign'' or central optic nerve lucency seen on contrast-enhanced computed tomography (CT), have also been found in metastases to the optic nerve. 23,24 Although typically more specific and sensitive than CT, MR imaging can still be inconclusive because the appearances of these two pathologies on imaging overlap considerably.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma of the Breast Metastatic to the Optic Nerve Mimicking an Optic Nerve Sheath Meningioma: Case Report and Review of the Literature

2005

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Isolated metastatic tumors to the optic nerve are extremely rare. We describe a rare and unusual case of metastatic breast carcinoma to the optic nerve that mimicked an optic nerve sheath meningioma in its presentation due to its indolent symptom progression, initial radiological appearance, and minimal growth on serial imaging. The patient, a 46-year-old woman with a history of stable metastatic breast carcinoma, presented with progressive visual loss in her right eye over a 6-month interval. Magnetic resonance imaging revealed an enhancing lesion in the optic canal with an extension to the right anterior clinoid process and planum sphenoidale and into the right orbital apex, consistent with the presumptive diagnosis of optic nerve sheath meningioma. The tumor was resected and pathologically confirmed to be metastatic carcinoma of the breast. The clinical course, radiological features, surgical approach, and treatment strategies are reviewed.KEYWORDS: Breast carcinoma, metastatic disease, ocular metastasis, optic nerve tumor, optic nerve sheath meningioma Carcinoma metastatic to the eye is rare. 1The reported incidence of ocular metastasis varies from 0.07 to 12%. The most frequently involved location is the uveal tract, particularly the posterior temporal choroid. [2][3][4][5][6][7] Metastases to the optic nerve occur far less frequently than ocular metastases. In a series of 227 patients with ocular metastasis, orbital metastasis, or both, Ferry and Font 3 reported that Skull Base, volume 15, number 4, 2005. Address for correspondence and reprint requests:

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Section: Discussionmentioning

confidence: 99%

Carcinoma of the Breast Metastatic to the Optic Nerve Mimicking an Optic Nerve Sheath Meningioma: Case Report and Review of the Literature

2005

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“…157 In the past, bone scintigraphy has been used to follow up vascularization of eye prostheses, 158 also reflecting physiological deposition onto hydroxyapatite. Meningiomas are known to calcify and frequently take up MDP [159][160][161] (Fig. 16).…”

Section: Metabolic Calcificationmentioning

confidence: 99%

Altered Biodistribution of Radiopharmaceuticals Used in Bone Scintigraphy

Zuckier

Martineau

2015

Seminars in Nuclear Medicine

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“…We present a case of an incidental finding of meningioma on bone scintigraphy followed by a brief discussion on the extra‐osseous accumulation of bone‐seeking radiopharmaceuticals, specifically in relation to meningiomas. There is limited published literature on the detection of meningioma with bone scintigraphy 3–8 .…”

Section: Introductionmentioning

confidence: 99%