1992
DOI: 10.1073/pnas.89.20.9809
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Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases.

Abstract: ABSTRACTcDNA encoding a hormone-and guanine nu- Hormone-stimulated adenylyl cyclase [ATP pyrophosphatelyase (cyclizing), EC 4.6.1.1] is one of the best-studied guanine nucleotide-binding protein (G protein)-regulated signaling pathways. Detailed molecular information on the multiplicity of receptors and G proteins has been available for some time, but much less has been known about the effector until quite recently. Major progress was achieved with the development of affinity purification of adenylyl cyclase o… Show more

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Cited by 170 publications
(106 citation statements)
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“…4.6.1.1) is the enzyme that converts ATP to cAMP. To date, nine distinct isoforms of mammalian AC (designated I to IX) and two splice variants of the type VIII enzyme have been cloned and characterized (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Because of the diversity in their regulation, the various AC isoforms may be broadly divided into five groups.…”
mentioning
confidence: 99%
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“…4.6.1.1) is the enzyme that converts ATP to cAMP. To date, nine distinct isoforms of mammalian AC (designated I to IX) and two splice variants of the type VIII enzyme have been cloned and characterized (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Because of the diversity in their regulation, the various AC isoforms may be broadly divided into five groups.…”
mentioning
confidence: 99%
“…The third group contains type II and type VII isoforms, which are phosphorylated and activated by protein kinase C (11,16). Type V and VI AC, which are inhibited by calcium (6)(7)(8)(9), form the fourth group. Finally, the recently characterized ACIX (originally named type X) is regulated by calcineurin (12), and because of this unique feature, it is classified in the fifth group.…”
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confidence: 99%
“…As mammalian types V and VI adenylyl cyelase are inhibited by submicromolar Ca 2+ concentrations [7][8][9][10], and appear to be the maj or adenylyl cyclase isozymes expressed in mammalian heart [7,9,11], we postulated the embryonic chick myocytes express avian type V and/or type VI isozymes [14]. We now report that: (i) RT-PCR detects type V and VI messages in mRNA isolated from preparations of isolated myocytes, and (ii) RNase protection assays suggest that type V message in 'myocyte RNA' is 4-5 times that of type VI message.…”
Section: Discussionmentioning
confidence: 99%
“…One was chick AC V (2 clones) which had 97.2% identity with all current known mammalian type V isoforrns at the amino acid level [9][10][11]19], and 86.1% identity with all current known mammalian type VI isoforms [7,8,11,20]. The other was chick AC VI (15 clones), which had 91.7% identity with all current known mammalian type VI isoforms at the amino acid level [7,8,11,20] and had 84.7% identity with all current known mammalian type V isoforms [9][10][11]19]. The identity between the PCR amplified sequences of chick AC V and AC VI was 86.1% at the amino acid level and 75.1% at the nucleotide acid level.…”
Section: Rt-pcrmentioning
confidence: 99%
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