Two malignant peripheral nerve lesions of non‐neurogenic origin

Green, Ruth A R; O’Donnell, Paul; Briggs, Timothy; Tirabosco, Roberto

doi:10.1111/j.1754-9485.2012.02343.x

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…In this case however, the history included unremitting pain in the right thigh that was refractory to analgesia as well as neuropathic pain in the foot. This raises the suspicion of both a pathological process involving the tibial nerve and a malignant lesion [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

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Extraskeletal Ewing’s Sarcoma Arising from the Sciatic Nerve: A Diagnostic Challenge

Sharma

Brown

Skinner

et al. 2015

Case Reports in Surgery

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Ewing's sarcoma is a common bone tumour of childhood but is a rare occurrence in individuals over 20 years of age. Few cases are reported as originating from peripheral nerves. We present an unusual case of extraosseous Ewing's sarcoma originating from the sciatic nerve in a 66-year-old patient which had the clinical hallmarks of a benign nerve sheath tumour. Following discussion at a multidisciplinary meeting, excision biopsy of the suspected benign nerve sheath tumour was planned. At operation, the mass had malignant features. Histology confirmed the presence of Ewing's sarcoma. Due to the morbidity of nerve resection, radiotherapy and chemotherapy were commenced. Ewing's sarcoma is known to mimic benign pathologies. In this case there were subtle signs of a malignant process in the form of unremitting pain. It is vital to keep in mind the less common tumours that can affect the peripheral nervous system in such cases.

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Section: Discussionmentioning

confidence: 99%

“…Benign tumours arising from peripheral nerves may present clinically with motor and/or sensory dysfunction and a positive Tinel's sign. Unremitting pain refractory to analgesia is however more suggestive of malignancy [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Extraskeletal Ewing’s Sarcoma Arising from the Sciatic Nerve: A Diagnostic Challenge

Sharma

Brown

Skinner

et al. 2015

Case Reports in Surgery

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Tumefactive appearance of peripheral nerve involvement in hematologic malignancies: a new imaging association

et al. 2015

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We present a new imaging pattern of "tumefactive" neurolymphomatosis, neuroleukemiosis, or neuroplasmacytoma in a series of 18 cases. We believe this pattern is associated with hematologic diseases directly involving the peripheral nerves. Knowledge of this association can provide a clue to clinicians in establishing the correct diagnosis. Bearing in mind that tumefactive NL, NLK, and NPLC is a newly introduced imaging pattern, we still recommend to biopsy patients with suspicion of a malignancy.

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Imaging of non-neurogenic peripheral nerve malignancy—a case series and systematic review

et al. 2020

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Two malignant peripheral nerve lesions of non‐neurogenic origin

Cited by 4 publications

References 26 publications

Extraskeletal Ewing’s Sarcoma Arising from the Sciatic Nerve: A Diagnostic Challenge

Extraskeletal Ewing’s Sarcoma Arising from the Sciatic Nerve: A Diagnostic Challenge

Tumefactive appearance of peripheral nerve involvement in hematologic malignancies: a new imaging association

Imaging of non-neurogenic peripheral nerve malignancy—a case series and systematic review

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