Two-layered dissolving microneedles formulated with intermediate-acting insulin

Ito, Yoshiaki; Hirono, Muneyuki; Fukushima, Keizo; Sugioka, Nobuyuki; Takada, Kanji

doi:10.1016/j.ijpharm.2012.06.047

Cited by 81 publications

(47 citation statements)

References 36 publications

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“…In the case of insulin-loaded microneedles, no significant differences in the blood glucose levels of rats were found between microneedle and subcutaneous administrations (Ito et al, 2012;Liu et al, 2012). Hyaluronic acid-based microneedles had a relative physiologic activity (RPA) of 94%-98% (Liu et al, 2012), whereas chondroitin sulfate microneedles had a RPA of 91%-100% compared with subcutaneous insulin solution (Ito et al, 2012). In dogs, for similar types of chondroitin sulfate microneedles, the RPA value was 59%-71% of subcutaneous insulin solution (Fukushima et al, 2010).…”

Section: A Development Challenges Of Peptide Delivery Formulationsmentioning

confidence: 99%

“…Dissolving microneedles also have been studied for delivery of other peptides such as desmopressin with fast absorption (absorption half-life 14 minutes) and high bioavailability (90%-93%) (Fukushima et al, 2011). Peptides were chemically stable for at least 1 month of storage at +4°C (Fukushima et al, 2010(Fukushima et al, , 2011 or at room temperature (Ito et al, 2012;Liu et al, 2012).…”

Section: A Development Challenges Of Peptide Delivery Formulationsmentioning

confidence: 99%

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Novel Delivery Systems for Improving the Clinical Use of Peptides

et al. 2015

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Section: A Development Challenges Of Peptide Delivery Formulationsmentioning

confidence: 99%

Section: A Development Challenges Of Peptide Delivery Formulationsmentioning

confidence: 99%

Novel Delivery Systems for Improving the Clinical Use of Peptides

et al. 2015

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“…the polymer or polysaccharide themselves [30][31][32]. These MNs dissolve or degrade in the skin and thereby leave no sharp medical waste after use [33][34][35]. The common process is shown in Fig.…”

Section: The Advantages Of Hydrogel Mnsmentioning

confidence: 99%

Hydrogel Microneedle Arrays for Transdermal Drug Delivery

Hong

Chen

et al. 2014

Nano-Micro Lett

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Stratum corneum is the main obstacle for drugs to pass through the skin. Microneedles are composed of arrays of micro-projections formed with different materials, generally ranging from 25-2000 μm in height. Microneedles straightly pierce the skin with its short needle arrays to overcome this barrier. Microneedles can be divided into several categories, for instance, solid microneedles, coated microneedles, and hollow microneedles and so on. However, all these types have their weak points related to corresponding mechanisms. In recent years, pioneering scientists have been working on these issues and some possible solutions have been investigated. This article will focus on the microneedle arrays consisting of hydrogels. Hydrogels are commonly used in drug delivery field. Hydrogel microneedles can be further divided into dissolving and degradable microneedles and phase transition microneedles. The former leaves drug with matrix in the skin. The latter has the feature that drugs in the matrix are delivered while the remaining ingredients can be easily removed from the skin after usage. For drugs which are required to be used every day, the phase transition microneedles are more acceptable. This article is written in order to summarize the advantages of these designs and summarize issues to be solved which may hinder the development of this technology.

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“…Previous studies have demonstrated the feasibility of using polymer MNs made of hyaluronic acid [12], a blend of starch and gelatin [16], carboxymethyl cellulose [17], Gantrez Ò AN-139 [18], dextrin [19], and chondroitin sulfate [20] for transdermal insulin delivery in vitro and in diabetic animals. However, inserting these dissolving MNs fully into the skin is usually difficult because of the wide needle geometry, low mechanical strength, and skin elasticity [12,16,20,21].…”

Section: Introductionmentioning

confidence: 99%