Two kinds of ketoprofen enteric gel beads (CA and CS-SA) using biopolymer alginate

Cheng, Bingchao; Li, Dongyang; Huo, Qiye; Zhao, Qianqian; Qi, Ling; Cui, Mengsuo; Pan, Weisan; Yang, Xinggang

doi:10.1016/j.ajps.2017.10.003

Cited by 13 publications

(8 citation statements)

References 34 publications

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“…The elongation after fracture of the composite film in this study was mostly influenced by the CS content. CS molecules contain a large number of amino and hydrogen groups, which form strong hydrogen bonds and prevent molecular slip, thereby increasing the tensile strength of the composite film, but reduce its elongation capability [34]. The elongation after fracture was also influenced by the cross-linking agent, CaCl 2 , which destroys the CS and SA hydrogen bonds, thus lowering their crystallinity.…”

Section: Results Of Orthogonal Experimentsmentioning

confidence: 99%

Preparation and Properties of Sodium Carboxymethyl Cellulose/Sodium Alginate/Chitosan Composite Film

2018

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A sodium alginate/chitosan solution was prepared by dissolving sodium alginate, chitosan, and glycerol in an acetic acid solution. This solution was then combined with a sodium carboxymethyl cellulose solution and the mixture was cast onto a glass plate and dried at a constant temperature of 60 • C. Then, a carboxymethyl cellulose/sodium alginate/chitosan composite film was obtained by immersing the film in a solution of a cross-linking agent, CaCl 2 , and air-drying the resulting material. First, the most advantageous contents of the three precursors in the casting solution were determined by a completely random design test method. Thereafter, a comprehensive orthogonal experimental design was applied to select the optimal mass ratio of the three precursors. The composite film obtained with sodium alginate, sodium carboxymethyl cellulose, and chitosan contents of 1.5%, 0.5%, and 1.5%, respectively, in the casting solution displayed excellent tensile strength, water vapor transmission rate, and elongation after fracture. Moreover, the presence of chitosan successfully inhibited the growth and reproduction of microorganisms. The composite film exhibited antibacterial rates of 95.7% ± 5.4% and 93.4% ± 4.7% against Escherichia coli and Staphylococcus aureus, respectively. Therefore, the composite film is promising for antibacterial food packaging applications.

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Section: Results Of Orthogonal Experimentsmentioning

confidence: 99%

Preparation and Properties of Sodium Carboxymethyl Cellulose/Sodium Alginate/Chitosan Composite Film

2018

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“…It forms a stable hydrogel in the presence of divalent cations, such as Ca 2+ , Ba 2+ and Sr 2+ ( Mørch et al, 2006 ). Alginate microbeads have been successfully used to encapsulate live cells ( Dhawan et al, 2020 ) and pharmaceutical compounds ( Cheng et al, 2018 ). Successful application of encapsulation technology is dependent on controlled production of optimal microbeads with low variation in size, shape, swelling properties and surface morphology ( Lee et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Sulfated Alginate Reduces Pericapsular Fibrotic Overgrowth on Encapsulated cGMP-Compliant hPSC-Hepatocytes in Mice

Syanda

Kringstad

Blackford

et al. 2022

Front. Bioeng. Biotechnol.

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Intra-peritoneal placement of alginate encapsulated human induced pluripotent stem cell-derived hepatocytes (hPSC-Heps) represents a potential new bridging therapy for acute liver failure. One of the rate-limiting steps that needs to be overcome to make such a procedure more efficacious and safer is to reduce the accumulation of fibrotic tissue around the encapsulated cells to allow the free passage of relevant molecules in and out for metabolism. Novel chemical compositions of alginate afford the possibility of achieving this aim. We accordingly used sulfated alginate and demonstrated that this material reduced fibrotic overgrowth whilst not impeding the process of encapsulation nor cell function. Cumulatively, this suggests sulfated alginate could be a more suitable material to encapsulate hPSC-hepatocyte prior to human use.

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“…The release profile studies indicated that, in both preparations, ketoprofen had a slow and sustained release in the gastrointestinal tract, relieved immediate pain, and reduced administration time and gastrointestinal irritation. These findings demonstrate that using alginate for drug encapsulation is an effective tool for short- and long-term applications [ 129 ]. Indeed, alginate nanoparticles have been used for cancer drug delivery (e.g., doxorubicin, 5-Fluorouracil or methylene blue) and as an antibiotic and antimicrobial drug delivery system for amoxicillin, ciprofloxacin, streptomycin, nisin, rifampicin, isoniazid, pyrazinamide and ethambutol [ 130 ].…”

Section: Applications Of Alginate In the Medical Fieldmentioning

confidence: 93%

Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders

et al. 2020

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Initially used extensively as an additive and ingredient in the food industry, alginate has become an important compound for a wide range of industries and applications, such as the medical, pharmaceutical and cosmetics sectors. In the food industry, alginate has been used to coat fruits and vegetables, as a microbial and viral protection product, and as a gelling, thickening, stabilizing or emulsifying agent. Its biocompatibility, biodegradability, nontoxicity and the possibility of it being used in quantum satis doses prompted scientists to explore new properties for alginate usage. Thus, the use of alginate has been expanded so as to be directed towards the pharmaceutical and biomedical industries, where studies have shown that it can be used successfully as biomaterial for wound, hydrogel, and aerogel dressings, among others. Furthermore, the ability to encapsulate natural substances has led to the possibility of using alginate as a drug coating and drug delivery agent, including the encapsulation of probiotics. This is important considering the fact that, until recently, encapsulation and coating agents used in the pharmaceutical industry were limited to the use of lactose, a potentially allergenic agent or gelatin. Obtained at a relatively low cost from marine brown algae, this hydrocolloid can also be used as a potential tool in the management of diabetes, not only as an insulin delivery agent but also due to its ability to improve insulin resistance, attenuate chronic inflammation and decrease oxidative stress. In addition, alginate has been recognized as a potential weight loss treatment, as alginate supplementation has been used as an adjunct treatment to energy restriction, to enhance satiety and improve weight loss in obese individuals. Thus, alginate holds the promise of an effective product used in the food industry as well as in the management of metabolic disorders such as diabetes and obesity. This review highlights recent research advances on the characteristics of alginate and brings to the forefront the beneficial aspects of using alginate, from the food industry to the biomedical field.

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Two kinds of ketoprofen enteric gel beads (CA and CS-SA) using biopolymer alginate

Cited by 13 publications

References 34 publications

Preparation and Properties of Sodium Carboxymethyl Cellulose/Sodium Alginate/Chitosan Composite Film

Preparation and Properties of Sodium Carboxymethyl Cellulose/Sodium Alginate/Chitosan Composite Film

Sulfated Alginate Reduces Pericapsular Fibrotic Overgrowth on Encapsulated cGMP-Compliant hPSC-Hepatocytes in Mice

Alginate: From Food Industry to Biomedical Applications and Management of Metabolic Disorders

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