Two independent aspects of tumor promotion

Berenblum, I.; Armuth, Vlasta

doi:10.1016/0304-419x(81)90005-6

Cited by 22 publications

(13 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PMA has been reported to stimulate the activity of a protein kinase (Castagna et al, 1982), to induce DNA synthesis and cell proliferation (Berenblum and Armuth, 1981), and to cause changes in the pattern of protein synthesis (Laskin et al, 1981;Hiwasa et al, 1982). Increased levels of mRNAs for proteins whose synthesis is stimulated by PMA have also been described (Hoffman-Liebermann et al 1981;Hiwasa et al, 1982).…”

Section: Discussionmentioning

confidence: 93%

Tumor promoter PMA stimulates the synthesis and secretion of mouse pro-urokinase in MSV-transformed 3T3 cells: this is mediated by an increase in urokinase mRNA content.

Belin¹,

Godeau²,

Vassalli³

1984

The EMBO Journal

View full text Add to dashboard Cite

In mouse MSV‐3T3 cells the synthesis of the urokinase form of plasminogen activator was increased 10‐fold after addition of the tumor promoter phorbol‐12‐myristate‐13‐acetate (PMA). PMA also stimulated the secretion of the protein into the culture medium, mostly in the form of enzymatically inactive pro‐urokinase. When assayed by injecting RNA into Xenopus laevis oocytes, the concentration of functional urokinase mRNA was found to be 6‐ to 10‐fold higher in the PMA‐treated cells; a similar increase in urokinase mRNA content was measured by hybridisation with a mouse urokinase cDNA probe. Thus, the induction of plasminogen activator by PMA in MSV‐3T3 cells is accounted for by an increased content of urokinase mRNA.

show abstract

Section: Discussionmentioning

confidence: 93%

Tumor promoter PMA stimulates the synthesis and secretion of mouse pro-urokinase in MSV-transformed 3T3 cells: this is mediated by an increase in urokinase mRNA content.

Belin¹,

Godeau²,

Vassalli³

1984

The EMBO Journal

View full text Add to dashboard Cite

show abstract

“…Observations in animal models suggest that tumor development follows three distinct phases, initiation, promotion, and progression. 43,44 The initiation phase is a rapid (i.e., taking place within one to two days), irreversible event that occurs when a normal cell is exposed to a carcinogen, which causes unrepairable or misrepaired DNA damage. DNA damage itself is not mutagenic.…”

Section: Cancer Chemoprevention: Modulating Tumor Promotion To Contromentioning

confidence: 99%

Mitochondria: A novel target for the chemoprevention of cancer

Hail¹

2005

Apoptosis

100

View full text Add to dashboard Cite

The mitochondria have emerged as a novel target for anticancer chemotherapy. This tenet is based on the observations that several conventional and experimental chemotherapeutic agents promote the permeabilization of mitochondrial membranes in cancerous cells to initiate the release of apoptogenic mitochondrial proteins. This ability to engage mitochondrial-mediated apoptosis directly using chemotherapy may be responsible for overcoming aberrant apoptosis regulatory mechanisms commonly encountered in cancerous cells. Interestingly, several putative cancer chemopreventive agents also possess the ability to trigger apoptosis in transformed, premalignant, or malignant cells in vitro via mitochondrial membrane permeabilization. This process may occur through the regulation of Bcl-2 family members, or by the induction of the mitochondrial permeability transition. Thus, by exploiting endogenous mitochondrial-mediated apoptosis-inducing mechanisms, certain chemopreventive agents may be able to block the progression of premalignant cells to malignant cells or the dissemination of malignant cells to distant organ sites as means of modulating carcinogenesis in vivo. This review will examine cancer chemoprevention with respect to apoptosis, carcinogenesis, and the proapoptotic activity of various chemopreventive agents observed in vitro. In doing so, I will construct a paradigm supporting the notion that the mitochondria are a novel target for the chemoprevention of cancer.

show abstract

“…Carcinogenesis can be viewed as a multistep process in which the genes controlling proliferation, differentiation, and apoptosis are transformed and altered under selective environmental pressures (14). Generally speaking, tumor development involves three distinct, yet closely linked, phases: initiation, promotion, and progression (13,47). The initiation phase is a rapid and irreversible event that occurs when a normal cell is exposed to a carcinogenic event.…”

mentioning

confidence: 99%