Two high-fertility mouse lines show differences in component fertility traits after long-term selection

Spitschak, Marion; Langhammer, Martina; Schneider, Falk; Renne, Ulla; Vanselow, Jens

doi:10.1071/rd07009

Cited by 22 publications

(44 citation statements)

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“…In a more recent study, McGee and Wainwright (2013) discovered that while independent freshwater populations of three-spined sticklebacks had evolved stronger suction force as an adaptation to feed on benthic food, different populations used different morphological means to create the same enhanced suction force. These examples illustrate the point that even in cases where the populations are derived from the same ancestral stock, and subject to (apparent) uniform selection, the response to selection may occur not only by parallel or convergent genetic changes influencing the same target traits, but also by genetic changes in different aspects of their phenotype (see Garland et al, 2010;Huey et al, 2000;Endler et al, 2001;Calboli et al, 2003;Spitschak et al, 2007 for additional examples).…”

Section: Functional Convergencementioning

confidence: 94%

Lakes and ponds as model systems to study parallel evolution

Merilä

2013

J Limnol

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Section: Functional Convergencementioning

confidence: 94%

Lakes and ponds as model systems to study parallel evolution

Merilä

2013

J Limnol

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“…This is particularly evident in the FL1 line [14]. This observation suggests that individual follicles release more than one oocyte.…”

mentioning

confidence: 85%

Occurrence of Polyovular Follicles in Mouse Lines Selected for High Fecundity

Alm

Kuhlmann

Langhammer

et al. 2010

Journal of Reproduction and Development

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Abstract. The aim of this study was to evaluate the prevalence of follicles with more than one oocyte (polyovular follicles, POFs) in mouse lines selected for high fecundity. The ovaries of 18 mice, 6 each from 3 different lines, were examined to evaluate the number of POFs and the follicular histology. Polyovular follicles were observed in the two high fecundity breeds, FL1 and FL2, as well as in the unselected control line, DUKsi. The highest number of POFs per ovary (27.0 ± 7.2) was found in the FL1 line. The FL2 and DUKsi lines had 1.9 ± 0.7 and 0.6 ± 0.3 polyovular follicles per ovary, respectively. Most of the POFs contained 2 oocytes (>80%), but occasionally follicles containing up to 7 oocytes were observed. Follicles with more than 2 oocytes were observed in the FL1 line only. Key words: High fecundity, Mice, Polyovular follicles (POFs) (J. Reprod. Dev. 56: [449][450][451][452][453] 2010) n normal adult mouse ovaries, follicles contain a germ cell surrounded by one or more layers of granulosa cells, according to the follicle developmental stage. However, follicles with more than one oocyte are rarely found [1]. During initial development, multiple germ cells are present within the individualizing follicles, although in most cases, excess cells are eliminated and mammalian ovarian follicles contain only one germ cell per follicle. Follicles with more than one oocyte are referred to as multi oocyte follicles (MOFs) or polyovular follicles (POFs). They have been reported to occur in the ovaries of humans [2], primates [3], dogs [4,5], cats [6], goats [7] and mice [8]. In rats and mice, the incidence of POFs increases when the animals are exposed to estrogen analogs such as diethylstilbestrol, estradiol benzoate or genistein in a dose-dependent manner [9,10]. The POFs observed in mice and humans have been postulated to be remnants of oocyte clusters that did not separate, and which have become enclosed in follicles during neonatal primordial follicle assembly [2,10,11].Fecundity (the number of offspring per litter) can be related to an increase in the number of ova ovulated or in the efficiency of fertilization and embryo development. Booroola sheep have multiple offspring because of an increase in the number of follicles ovulated, which is related to the fecundity gene FecB, a mutation in bone morphogenetic protein receptor IB. The presence of FecB increases litter size by one or two extra lambs [12]. Polyovular follicles have been especially noted in bitches [13]. The presence of POFs could affect the number of oocytes recovered in assisted reproductive protocols and may also influence the ovulation rate and prolificity of these animals [5].Previous analysis of fecundity traits revealed that in high fecundity mouse lines (FL1, FL2), the number of ova ovulated is higher than the number of corpora lutea (CL) present. This is particularly evident in the FL1 line [14]. This observation suggests that individual follicles release more than one oocyte. The occurrence of polyovular follicles in specific strain...

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“…Interestingly, a significantly increased rate of gestational losses (as observed for FL1) has also been described for the Norwegian high-FL (Holt et al 2004). Moreover, the majority of gestational losses in FL1 animals occur during the first 4 days of pregnancy (Spitschak et al 2007). It is therefore tempting to speculate that not all of the multiple oocytes that have been ovulated by FL1 females from only one follicle are properly pregnable.…”

Section: Characterization Of the Fls Fl1 And Fl2 On The Female Sidementioning

confidence: 83%

“…While FL2 Two outbred mouse models for the phenotype 'high fertility' females displayed increased total plasma progesterone concentrations during the cycle, this phenomenon could not be observed in FL1 mice ( Fig. 3A; Spitschak et al 2007). In turn, FL1 females exhibited multiple (up to seven) oocytes per follicle (Alm et al 2010).…”

Section: Characterization Of the Fls Fl1 And Fl2 On The Female Sidementioning

confidence: 93%

“…Additionally, analysis of embryonic survival rates revealed increased gestational losses only in FL1 animals. FL1 females release an average of w28 oocytes per cycle, compared with w12 oocytes released by Ctrl females (Spitschak et al 2007). Among this high number of ovulated oocytes, w18 develop into living offspring (compare with Table 1).…”

Section: Characterization Of the Fls Fl1 And Fl2 On The Female Sidementioning

confidence: 98%

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High-fertility phenotypes: two outbred mouse models exhibit substantially different molecular and physiological strategies warranting improved fertility

Langhammer¹,

Michaelis²,

Hoeflich³

et al. 2014

Reproduction

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Animal models are valuable tools in fertility research. Worldwide, there are more than 400 transgenic or knockout mouse models available showing a reproductive phenotype; almost all of them exhibit an infertile or at least subfertile phenotype. By contrast, animal models revealing an improved fertility phenotype are barely described. This article summarizes data on two outbred mouse models exhibiting a 'high-fertility' phenotype. These mouse lines were generated via selection over a time period of more than 40 years and 161 generations. During this selection period, the number of offspring per litter and the total birth weight of the entire litter nearly doubled. Concomitantly with the increased fertility phenotype, several endocrine parameters (e.g. serum testosterone concentrations in male animals), physiological parameters (e.g. body weight, accelerated puberty, and life expectancy), and behavioral parameters (e.g. behavior in an open field and endurance fitness on a treadmill) were altered. We demonstrate that the two independently bred high-fertility mouse lines warranted their improved fertility phenotype using different molecular and physiological strategies. The fertility lines display female-as well as male-specific characteristics. These genetically heterogeneous mouse models provide new insights into molecular and cellular mechanisms that enhance fertility. In view of decreasing fertility in men, these models will therefore be a precious information source for human reproductive medicine. Translated abstractA German translation of abstract is freely available at

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Two high-fertility mouse lines show differences in component fertility traits after long-term selection

Cited by 22 publications

References 24 publications

Lakes and ponds as model systems to study parallel evolution

Lakes and ponds as model systems to study parallel evolution

Occurrence of Polyovular Follicles in Mouse Lines Selected for High Fecundity

High-fertility phenotypes: two outbred mouse models exhibit substantially different molecular and physiological strategies warranting improved fertility

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