“…Regulation of apoE expression has been extensively studied in transfected cells (Reardon et al, 1986;Smith et al, 1988;García et al, 1996;Harris et al, 2004b) and in transgenic mice (Shachter et al, 1993;Simonet et al, 1993;Allan et al, 1995Allan et al, , 1997Shih et al, 2000;Grehan et al, 2001a,b;Zheng et al, 2004) expressing apoE genomic or cDNA constructs. Although these systems have provided valuable information, practical considerations have limited systematic study of apoE expression.…”