Two genetic variants in prostate stem cell antigen and gastric cancer susceptibility in a chinese population

Wu, Chen; Wang, Guanghai; Yang, Ming; Huang, Liming; Yu, Dianke; Tan, Wen; Lin, Dongxin

doi:10.1002/mc.20565

Cited by 53 publications

(80 citation statements)

References 20 publications

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“…More recently, several studies have assessed the relationship between the polymorphism of PSCA C > T and the susceptibility to GC. Nevertheless, controversial results exist regarding the association of PSCA with the risk of GC (Sakamoto et al, 2008;Matsuo et al, 2009;Wu et al, 2009;Lu et al, 2010;Ou et al, 2010;Lochhead et al, 2011;Song et al, 2011;Zeng et al, 2011;Sala et al, 2012). Therefore, we conducted this meta-analysis to confirm these associations.…”

Section: Introductionmentioning

confidence: 89%

“…Following the above inclusion and exclusion criteria, 9 publications were included in the final meta-analysis (Sakamoto et al, 2008;Matsuo et al, 2009;Wu et al, 2009;Lu et al, 2010;Ou et al, 2010;Lochhead et al, 2011;Song et al, 2011;Zeng et al, 2011;Sala et al, 2012). Characteristics of studies focusing on PSCA rs2294008 C > T are summarized in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Association of the PSCA rs2294008 C＞T Polymorphism with Gastric Cancer Risk: Evidence from a Meta-Analysis

Yao¹,

Gu²,

Gu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Multiple studies have reported associations between the PSCA rs2294008 C > T polymorphism and GC, but susceptibility has proven inconsistent. Therefore, we estimates the relationship between the rs2294008 C > T polymorphism and GC by meta-analysis. Methods: PubMed, Embase and Web of Science databases were searched and nine independent case-control studies were included in this meta-analysis. Crude ORs with 95% CIs were extracted according to the Mantal-Haenszel method and pooled to assess the strength of the association. Results: We observed that the PSCA rs2294008 C > T polymorphism was significantly correlated with GC risk when all studies were pooled into the meta-analysis. Further subgroup analysis showed the polymorphism to be linked with diffuse and noncardia GC in the allele contrast model, homozygote codominant model, dominant model, and recessive model. However, no connection was apparent for intestinal and cardia GC. In the stratified analysis by ethnicity, significant associations were observed in Asians for the recessive model. Interestingly, the relationship was particularly significant in the Chinese population. Conclusions: Our findings suggest that the PSCA rs2294008 C > T polymorphism is a risk factor for GC, especially in diffuse and noncardia GC and in Chinese.

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Section: Introductionmentioning

confidence: 89%

Section: Study Characteristicsmentioning

confidence: 99%

Association of the PSCA rs2294008 C＞T Polymorphism with Gastric Cancer Risk: Evidence from a Meta-Analysis

Yao¹,

Gu²,

Gu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…In 2008, the Study Group of the Millennium Genome Project for Cancer found an association between the rs2294008 single nucleotide polymorphism (SNP) in the prostate stem cell antigen gene (PSCA) and the risk of GC in Japanese and Korean populations (14). The association between GC and rs2294008 has also been identified in Chinese Han and Caucasian populations (15,16).…”

Section: Introductionmentioning

confidence: 99%

Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori-negative gastric cancer among various populations in China

Zhao

Geng

et al. 2013

Molecular and Clinical Oncology

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Abstract. Gastric cancer is a lethal disease with a high mortality rate. Studies have suggested that prostate stem cell antigen (PSCA) rs2294008 polymorphism is associated with gastric cancer (GC). In this case-control study, we investigated rs2294008 polymorphism in the Tibet, Hui and Han nationalities in the Qinghai area of China. Genomic DNA was extracted from the peripheral blood of 286, 315 and 350 healthy volunteers and from 219, 233 and 265 Helicobacter pylori-negative non-cardia GC patients from the Tibet, Hui and Han populations, respectively. The rs2294008 polymorphism was analyzed by denaturing high-performance liquid chromatography. rs2294008 CT and TT genotypes were associated with GC both in the Tibet and Han populations (adjusted OR=1.51, 1.47, 2.01, 1.85; 95% CI, 1.04-2.19, 1.05-2.06, 1.04-3.88, 1.03-3.34; P=0.030, 0.025, 0.039, 0.040, respectively). rs2294008 TT genotype was associated with GC in the Hui population (adjusted OR=2.14; 95% CI, 1.29-3.55; P=0.003). Furthermore, when stratified by histopathology, the rs2294008 CT and TT genotypes were associated with diffuse GC in the Tibet and Han nationalities (adjusted OR=1.93, 1.73, 2.69, 2.86; 95% CI, 1.09-3.44, 1.01-2.95, 1.06-6.84, 1.27-6.46; P=0.025, 0.045, 0.038, 0.011, respectively). However, the rs2294008 TT genotype was associated with both intestinal and diffuse types of GC (adjusted OR=2.10, 2.21; 95% CI, P=0.012, 0.023, respectively) and the rs2294008 CT genotype was only associated with intestinal-type GC in the Hui nationalitiy group (adjusted OR=1.60; 95% CI, 1.04-2.47; P=0.034). The results therefore showed that rs2294008 may differentially contribute to GC among different nationalities in one area and its role is independent from Helicobacter pylori-infection.

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“…It was also reported that the T allele was especially associated with noncardia GC in Chinese and Caucasian patients but with cardia GC in Korean patients. (14,(18)(19)(20)(21) The cell growth inhibition activity of PSCA was also demonstrated on gallbladder cancer (GBC) cells. (35) The GBC cells introduced with PSCA cDNA showed lower in vitro and in vivo growth than controls, and their invasion ability assayed with a Matrigel chamber was also attenuated.…”

Section: à6mentioning

confidence: 99%

“…Later, the association of rs2976392 or rs2294008 with GC was validated in other Japanese and Korean panels and in Chinese and Caucasian studies ( Table 2). (14)(15)(16)(17)(18)(19)(20)(21) Intriguingly, PSCA was also identified as a gene related to bladder-cancer susceptibility for Caucasians by GWAS. (22) Our subsequent analyses revealed that the 1q22 region contains 13 SNP with strong LD over five genes, but we have concluded that the Mucin 1 (MUC1) gene is responsible for the observed association as the second DGC susceptibility gene; rs2070803 with P = 2.20 9 10 À6 , adjusted per allele odds ratio = 1.63 (606 cases and 1264 controls), which was replicated in additional Japanese (P = 3.93 9 10…”

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confidence: 99%

Genetic factors related to gastric cancer susceptibility identified using a genome‐wide association study

et al. 2012

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Gastric cancer (GC) is one of the major malignant diseases worldwide, especially in Asia, where Japan and Korea have the highest incidence in the world. Gastric cancer is classified into intestinal and diffuse types. While the former is almost absolutely caused by Helicobacter pylori infection as the initial insult, the latter seems to include cases in which the role of infection is limited, if any, and a contribution of genetic factors is anticipated. Previously, we performed a genome-wide association study (GWAS) on diffusetype GC by using single nucleotide polymorphisms (SNP) catalogued for Japanese population (JSNP), and identified a prostate stem cell antigen (PSCA) gene encoding a glycosylphosphatidylinositol-anchored cell surface antigen as a GC susceptibility gene. From the second candidate locus identified using the GWAS, 1q22, we found the Mucin 1 (MUC1) gene encoding a cell membranebound mucin protein as another gene related to diffuse-type GC. A two-allele analysis based on risk genotypes of the two genes revealed approximately 95% of Japanese population have at least one of the two risk genotypes, and approximately 56% of the population have both risk genotypes. The two-SNP genotype might offer ample room to further stratify a high GC risk subpopulation in Japan and Asia by adding another genetic and/or non-genetic factor. Recently, a GWAS on the Chinese population disclosed an additional three GC susceptibility loci: 3q13.31, 5p13.1 and 10q23. (Cancer Sci 2013; 104: 1-8) G astric cancer (GC) is one of the major malignant diseases and the second causal of cancer death worldwide.(1) It is usually classified into two types, intestinal and diffuse, a classification which was originally based on histological observation but is recently thought to reflect its pathogenesis.(2) The majority of intestinal-type GC (IGC) arises in the sequence of inflammatory change of the gastric epithelium resulting from bacterial infection; Helicobacter pylori (HP) infectionchronic inflammation -intestinal metaplasia -dysplasia -adenocarcinoma. In contrast, de novo diffuse-type GC (DGC) is thought to emerge in a histologically almost normal epithelium as a consequence of some genetic change that occurred in gastric stem cells and/or epithelial precursor cells, although some cases with DGC might represent dedifferentiated stages of IGC, and a contribution of HP is also suggested.(3) In other words, it is apparent that the pathogenesis of IGC is initiated by HP infection, a class I carcinogen acknowledged by WHO, and therefore IGC is essentially a preventable disease by eradicating HP infection. However, DGC might develop earlier in life than IGC, (4) and no definite DGC-specific environmental risk factor has been established. Therefore, so far we have neither solid strategy nor promising theory to envision a consistent diminution of the incidence of DGC.The incidence of GC has strong geographical and ethnical characteristics. For example, it is one of the rare cancers in North America and Europe, while its incidence is s...

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Two genetic variants in prostate stem cell antigen and gastric cancer susceptibility in a chinese population

Cited by 53 publications

References 20 publications

Association of the PSCA rs2294008 C＞T Polymorphism with Gastric Cancer Risk: Evidence from a Meta-Analysis

Association of the PSCA rs2294008 C＞T Polymorphism with Gastric Cancer Risk: Evidence from a Meta-Analysis

Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori-negative gastric cancer among various populations in China

Genetic factors related to gastric cancer susceptibility identified using a genome‐wide association study

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