Two Fungal Infections of Inflatable Penile Prostheses in Diabetics

Abstract

IntroductionPenile prosthesis infections have decreased since the introduction of antibiotic‐coated implants. Infections that do occur can be from more rare and virulent organisms than the traditional skin flora historically implicated.AimIn this report, we present two cases of inflatable penile prosthesis (IPP) infection from C andida organisms in insulin‐dependent diabetic patients.MethodsCase report with literature review.Main Outcome MeasuresResolution of the two cases.ResultsBoth patients were found to have insulin‐dependent diabetes. Both patients also presented with infection of the device with Candida species, with the implant pump adherent to their scrotal skin.ConclusionsThis report supports the emerging literature that the flora of IPP infections is changing. We suggest considering adding antifungal agents to antibiotic coatings, dips, or washout solutions at the time of penile prosthesis surgery in diabetic patients. Cotta BH, Butcher M, Welliver C, McVary K, and Köhler T. Two fungal infections of inflatable penile prostheses in diabetics. Sex Med 2015;3:339–342.

Candida sp. Infections in Patients with Diabetes Mellitus

“…In DM type 2, the animal models can be both obese and non-obese animals with varying degrees of insulin resistance and beta cell failure [376]. The animal models (e.g., species, strain, gender, genetic) of DM type 1 and type 2 have diverse purposes, and the choice of a model depends on the purpose of the study (e.g., applied for pharmacological or genetics studies and understanding disease mechanisms) [376,377,378,379,380,381]. Table 6 summarizes the main animal models used in diabetes mellitus in vivo studies.…”

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“…2A, B). Opportunistic fungus can also cause this picture particularly in diabetics [21]. For this group, assessing response to a 1-month course of oral antibiotics such as Rifampin® and Bactrim® may occasionally prolong the implanted status for years without the necessity of surgery.…”