Two Fortuitous Papers in 1917 That Conceived Diagnostic Cytopathology

Chantziantoniou, Nikolaos

doi:10.1159/000473858

Cited by 4 publications

(7 citation statements)

References 8 publications

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“…This has led to a reduction in mortality of cervical cancer considerably up to 70% in countries participating in cervical screening since the last century. 4,5 There have been many efforts and trials to employ exfoliative cytological methods for oral mucosal lesions. 6 However, initial results in the last century were disappointing due to high false-negative rates.…”

Section: Introductionmentioning

confidence: 99%

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Abrasive cytohistology of squamous epithelial lesions

Burkhardt

Schwarz-Furlan

2018

Translational Research in Oral Oncology

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Objective: To describe a method to retrieve cellular and tissue elements of oral squamous epithelium obtained by abrasive methods and to conduct investigations by cytohistology. Method: We developed a special gelatine pocket suitable for paraffin embedding of sparse material obtained from brush biopsies (BBs). This was subjected to combined evaluation of a cytological (smear) and histological examination of the 'tissue sections'referred as cytohistology. Four diagnostic categories were applied for evaluation. Other special diagnostic methods were also applied in addition to recording dysplasia. Results: A total of 51, 755 BBs from suspicious lesions of the oral mucosa (mostly oral potentially malignant disorders-OPMD) were evaluated for the presence of carcinoma or dysplasia; in all, 1.7% were positive, 78.2% were negative for any epithelial atypia, 16.8% atypical and 3.3% inadequate. All BBs also had cytohistological evaluation. A 'positive' diagnosis by cytohistology was a reliable indicator of dysplasia or carcinoma, requiring further incisional/excisional biopsy. In the 'atypical' category, a variety of lesions were found, about half being dysplasia or carcinoma. This category challenges the clinician for further clinical, therapeutic and/or excisional examination. In 'negative' cases with persistence of the lesion, a re-examination in 1-year sequence is recommended. Conclusion: Cytohistology of material derived by abrasive methods allows earlier detection of dysplasia/carcinoma. A number of additional oncological and non-oncological findings make this method a valuable non-invasive diagnostic procedure for oral mucosal lesions.

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Section: Introductionmentioning

confidence: 99%

“…This has led to a reduction in mortality of cervical cancer considerably up to 70% in countries participating in cervical screening since the last century. 4,5…”

Section: Introductionmentioning

confidence: 99%

Abrasive cytohistology of squamous epithelial lesions

Burkhardt

Schwarz-Furlan

2018

Translational Research in Oral Oncology

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“…As to the work and legacy of Dr. G.N. Papanicolaou, it is well known to most of the readers, but perhaps less well known is the important role of his wife, Andromache, who was closely involved in most of the inventions that he made during his career in the USA [ 2 , 3 ]. In fact, Dr. G.N.…”

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confidence: 99%

Meeting Report: The Kymi Odyssey Honorary Ceremony and the Future G.N. Papanicolaou Museum

Syrjänen

2023

Acta Cytologica

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“…After all, the Pap test arose from societal and scientific tectonics over 40 years [ 1 ]. After early experimental work by Dr. George N. Papanicolaou in 1917 [ 2 ], the Pap test was refined by 1945 [ 3 , 4 ], coined, and promoted by the American Cancer Society (ACS) in 1948 [ 5 ], then launched into mainstream healthcare in USA by 1957, when Acta Cytologica also formalized to catalogue progress [ 2 , 5 ].…”

mentioning

confidence: 99%

Two Fortuitous Papers in 1917 That Conceived Diagnostic Cytopathology

Cited by 4 publications

References 8 publications

Abrasive cytohistology of squamous epithelial lesions

Abrasive cytohistology of squamous epithelial lesions

Meeting Report: The Kymi Odyssey Honorary Ceremony and the Future G.N. Papanicolaou Museum

Back from the Future: Rational Accountabilities for Cytopathology in Pap Test Cervical Cancer Screening Arising from Covid19

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