Two for one: regulatory RNAs that encode small proteins

Aoyama, Jordan J.; Storz, Gisela

doi:10.1016/j.tibs.2023.09.002

Cited by 2 publications

(1 citation statement)

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“…The mechanisms by which plant lncRNAs function are numerous, and some of them are better understood in animals [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. Recent studies have shown that the short open reading frames (sORFs) of some plant lncRNAs encode functional small peptides (micropeptides) with a size of around 5 to 100 amino acids [ 10 , 12 , 17 , 18 , 19 , 20 , 21 , 22 ]. Importantly, these lncRNAs also include precursors of many microRNAs, which code for peptides called miPEPs (peptides encoded by primary microRNAs), and some trans-acting siRNAs [ 19 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Activity of Artificial Plant Peptides Corresponding to the Translational Products of Small ORFs in Primary miRNAs and Other Long “Non-Coding” RNAs

Erokhina,

Ryazantsev,

Zavriev

et al. 2024

Plants

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Generally, lncPEPs (peptides encoded by long non-coding RNAs) have been identified in many plant species of several families and in some animal species. Importantly, molecular mechanisms of the miPEPs (peptides encoded by primary microRNAs, pri-miRNAs) are often poorly understood in different flowering plants. Requirement for the additional studies in these directions is highlighted by alternative findings concerning positive regulation of pri-miRNA/miRNA expression by synthetic miPEPs in plants. Further extensive studies are also needed to understand the full set of their roles in eukaryotic organisms. This review mainly aims to consider the available data on the regulatory functions of the synthetic miPEPs. Studies of chemically synthesized miPEPs and analyzing the fine molecular mechanisms of their functional activities are reviewed. Brief description of the studies to identify lncORFs (open reading frames of long non-coding RNAs) and the encoded protein products is also provided.

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