Two fetal deaths associated with maternal sepsis and with thrombosis of the intervillous space of the placenta

Bendon, Robert W.; Bornstein, S.; Faye-Petersen, Ona

doi:10.1016/s0143-4004(98)90078-9

Cited by 22 publications

(13 citation statements)

References 6 publications

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“…Chorioamnionitis with acute villitis is seen with fetal bacterial sepsis, usually caused by either streptococci or gram-negative enteric bacilli (Langston et al 1997). Finally, chorioamnionitis with focal acute intervillositis and perivillous fi brin may be seen with maternal sepsis, again usually caused by streptococci or gram-negative enteric bacilli (Bendon et al 1998).…”

Section: Placental Inflammationmentioning

confidence: 99%

Placental Inflammation

Redline¹

2007

Fetal and Neonatal Pathology

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Section: Placental Inflammationmentioning

confidence: 99%

Placental Inflammation

Redline¹

2007

Fetal and Neonatal Pathology

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“…Maternal sepsis is associated with different histopathologic changes in the placenta . The syncytiotrophoblast is often the first cell lineage to show the hypoxic changes.…”

Section: Part II the Histopathology Of Placental Infectionmentioning

confidence: 99%

Defense and infection of the human placenta

Heerema-McKenney

2018

APMIS

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The placenta functions as a shield against infection of the fetus. The innate and adaptive immune defenses of the developing fetus are poorly equipped to fight infections. Infection by bacteria, viruses, and protozoa may cause infertility, spontaneous abortion, stillbirth, growth retardation, anomalies of development, premature delivery, neonatal morbidity, and mortality. However, appreciation of the human microbiome and host cell-microbe interactions must be taken into consideration as we try to determine what interactions are pathologic. Infection is typically recognized histologically by the presence of inflammation. Yet, several factors make comparison of the placenta to other human organs difficult. The placenta comprises tissues from two persons, complicating the role of the immune system. The placenta is a temporary organ. It must be eventually expelled; the processes leading to partuition involve maternal inflammation. What is normal or pathologic may be a function of timing or extent of the process. We now must consider whether bacteria, and even some viruses, are useful commensals or pathogens. Still, recognizing infection of the placenta is one of the most important contributions placental pathologic examination can give to care of the mother and neonate. This review provides a brief overview of placental defense against infection, consideration of the placental microbiome, routes of infection, and the histopathology of amniotic fluid infection and TORCH infections.

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“…In particular, the effect of maternal periodontitis in the progression and outcome of a pregnancy can be interpreted with the help of two cases that have been adequately documented [53]. The first case concerns the ability of the endotoxins of the Gram-negative periodontal bacteria to cross the placenta, through the blood circulation and decisively affect the development of the fetus, as evidenced by the identification of bacteria associated to periodontitis in cultures of amniotic fluid [54][55][56][57]. The second case relates to the treatment of maternal bacteremia with the overproduction of pre-inflammatory cytokines and enhances of the immune response of the thermal shock proteins which were shown by the detection of inflammatory mediators in high concentrations in the amniotic fluid of women who delivered preterm [58].…”

Section: Maternal Periodontitis and Pregnancymentioning

confidence: 99%

Periodontal Disease, Infertility Treatment and In Vitro Fertilization (IVF)

Pavlatou¹,

Dokou²,

Àlex³

et al. 2014

JFIV Reprod Med Genet

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Periodontal disease and particularly periodontitis is a chronic bacterial infection, and belongs, as well as various other acute or subclinical infections, especially of the urogenital system, appendicitis and AbstractIn the last years, research interest has focused on the possible role of maternal periodontitis in the achievement of a pregnancy, as well as the possible role of paternal periodontitis in the success of medication administered for the treatment of infertility. The purpose of this publication is the presentation of the limited number of research data that highlight the relationship between maternal/paternal periodontitis and the effectiveness of fertility treatment.

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Two fetal deaths associated with maternal sepsis and with thrombosis of the intervillous space of the placenta

Cited by 22 publications

References 6 publications

Placental Inflammation

Placental Inflammation

Defense and infection of the human placenta

Periodontal Disease, Infertility Treatment and In Vitro Fertilization (IVF)

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