Two Familial Mesothelioma Cases with High Concentrations of Soluble Cytokeratin 19 Fragment in Pleural Fluid.

Mesothelioma in blood related subjects: Report of 11 clusters among 1954 Italy cases and review of the literature

“…Overall, these data suggest that exposure to fibers with a severe carcinogenic effect and longer biopersistence [Berry, 1999] has occurred in some familial cases. Moreover, the presence of asbestos bodies in several cases [Smith et al, 1968;Dawson et al, 1992;Bianchi et al, 1993Bianchi et al, , 2004Hiyama et al, 1998] is a further evidence of previous exposure [FIOH, 1997]. Asbestosis in cohabitants [Li et al, 1978[Li et al, , 1989Orn et al, 1991;Schneider et al, 1995] may indicate shared exposures.…”

“…However, clusters with an extensive family history of different types of cancer [Ascoli et al, 1998[Ascoli et al, , 2001Picklesimer et al, 2005] suggest a familial susceptibility to tumors in general and the possibility of an inherited predisposition to this malignancy cannot be ruled out. It is noteworthy that eight studies have documented examples of cancers of the respiratory tract in the family tree [Milne, 1976;Li et al, 1978;Krousel et al, 1986;Munoz et al, 1988;Orn et al, 1991;Ascoli et al, 1998;Hiyama et al, 1998;Picklesimer et al, 2005].…”

Mesothelioma in household members of asbestos-exposed workers: 32 United States cases since 1990

“…(Family relationships and occupations of these household contacts total 36 since 3 cases had their own occupational exposures). The identification of household exposure as the mechanism for family mesothelioma has been complicated by reporting family cases with their own occupational [Bianchi et al, 1993;Hiyama et al, 1998] or other nonoccupational exposures such as neighborhood proximity to an industrial source, asbestos present in buildings of employment, or asbestos in cigarette filters. Family cases resulting from household exposure have been confounded with possible genetic predisposition to mesothelioma reported in consanguineous family members who have been occupationally exposed [Risberg et al, 1980.;Martensson et al, 1984;Lynch et al, 1985;Krousel et al, 1986;Hammar et al, 1989].…”

“…Family exposures are combined with building exposures (asbestos present in offices or schools) or environmental exposures as ''non-occupational'' exposures [Konetzke et al, 1990;Iscovich et al, 1999;Magnani et al, 2000]. Many cases described as family members had their own, sometimes less recognized exposures [Risberg et al, 1980;Lynch et al, 1985;Hammar et al, 1989;Dawson et al, 1992;Bianchi et al, 1993;Ascoli et al, 1998;Hiyama et al, 1998]. The concern of other reports of family cases was with a possible genetic cause, looking at mesothelioma in occupationally exposed blood relatives [Risberg et al, 1980;Martensson et al, 1984;Krousel et al, 1986] who may have lived in the same household [Hammar et al, 1989].…”